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potassium channel, subfamily K, member 12
Symbols KCNK12; THIK2
External IDs OMIM607366 MGI2684043 HomoloGene11107 IUPHAR: K2P12.1 GeneCards: KCNK12 Gene
Species Human Mouse
Entrez 56660 210741
Ensembl ENSG00000184261 ENSMUSG00000050138
UniProt Q9HB15 Q76M80
RefSeq (mRNA) NM_022055 NM_199251
RefSeq (protein) NP_071338 NP_954859
Location (UCSC) Chr 2:
47.6 - 47.65 Mb
Chr 17:
88.15 - 88.2 Mb
PubMed search [1] [2]

Potassium channel, subfamily K, member 12, also known as KCNK12 is a human gene. The protein encoded by this gene, K2P12.1, is a potassium channel containing two pore-forming P domains.[1]


See also


  1. ^ Rajan S, Wischmeyer E, Karschin C, Preisig-Müller R, Grzeschik KH, Daut J, Karschin A, Derst C (March 2001). "THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+ channels". J. Biol. Chem. 276 (10): 7302–11. doi:10.1074/jbc.M008985200. PMID 11060316.  

Further reading

  • Girard C, Duprat F, Terrenoire C, et al. (2001). "Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels.". Biochem. Biophys. Res. Commun. 282 (1): 249-56. doi:10.1006/bbrc.2001.4562. PMID 11263999.  
  • Nyholt DR, LaForge KS, Kallela M, et al. (2008). "A high-density association screen of 155 ion transport genes for involvement with common migraine.". Hum. Mol. Genet. 17 (21): 3318-31. doi:10.1093/hmg/ddn227. PMID 18676988.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.  
  • Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (2001). "Potassium leak channels and the KCNK family of two-P-domain subunits.". Nat. Rev. Neurosci. 2 (3): 175-84. PMID 11256078.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Theilig F, Goranova I, Hirsch JR, et al. (2008). "Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1) K channels in the mammalian kidney.". Cell. Physiol. Biochem. 21 (1-3): 63-74. doi:10.1159/000113748. PMID 18209473.  

External links



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