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potassium channel, subfamily K, member 16
Symbols KCNK16; TALK1; MGC133123
External IDs OMIM607369 MGI1921821 HomoloGene75328 IUPHAR: K2P16.1 GeneCards: KCNK16 Gene
Species Human Mouse
Entrez 83795 74571
Ensembl ENSG00000095981 ENSMUSG00000023387
UniProt Q96T55 n/a
RefSeq (mRNA) NM_001135107 XM_138942
RefSeq (protein) NP_115491 XP_138942
Location (UCSC) Chr 6:
39.39 - 39.4 Mb
Chr 14:
21.08 - 21.09 Mb
PubMed search [1] [2]

Potassium channel subfamily K member 16 is a protein that in humans is encoded by the KCNK16 gene.[1][2] The protein encoded by this gene, K2P16.1, is a potassium channel containing two pore-forming P domains.[1][2]


See also


  1. ^ a b Girard C, Duprat F, Terrenoire C, Tinel N, Fosset M, Romey G, Lazdunski M, Lesage F (Mar 2001). "Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels". Biochem Biophys Res Commun 282 (1): 249-56. doi:10.1006/bbrc.2001.4562. PMID 11263999.  
  2. ^ a b Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev 57 (4): 527-40. doi:10.1124/pr.57.4.12. PMID 16382106.  

Further reading

  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805-11. doi:10.1038/nature02055. PMID 14574404.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (2001). "Potassium leak channels and the KCNK family of two-P-domain subunits.". Nat. Rev. Neurosci. 2 (3): 175-84. PMID 11256078.  
  • Han J, Kang D, Kim D (2003). "Functional properties of four splice variants of a human pancreatic tandem-pore K+ channel, TALK-1.". Am. J. Physiol., Cell Physiol. 285 (3): C529-38. doi:10.1152/ajpcell.00601.2002. PMID 12724142.  
  • Gierten J, Ficker E, Bloehs R, et al. (2008). "Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein.". Br. J. Pharmacol. 154 (8): 1680-90. doi:10.1038/bjp.2008.213. PMID 18516069.  

External links



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