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Potassium channel, subfamily K, member 4
Symbols KCNK4; K2p4.1; TRAAK; TRAAK1
External IDs OMIM605720 MGI1298234 HomoloGene7391 IUPHAR: K2P4.1 GeneCards: KCNK4 Gene
RNA expression pattern
PBB GE KCNK4 219883 at tn.png
More reference expression data
Species Human Mouse
Entrez 50801 16528
Ensembl ENSG00000182450 ENSMUSG00000024957
UniProt Q9NYG8 Q0VD85
RefSeq (mRNA) NM_033310 NM_008431
RefSeq (protein) NP_201567 NP_032457
Location (UCSC) Chr 11:
63.82 - 63.83 Mb
Chr 19:
6.99 - 7 Mb
PubMed search [1] [2]

Potassium channel subfamily K member 4 is a protein that in humans is encoded by the KCNK4 gene.[1][2][3]

Potassium channels play a role in many cellular processes including maintenance of the action potential, muscle contraction, hormone secretion, osmotic regulation, and ion flow. This gene encodes K2P4.1, one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. K2P4.1 homodimerizes and functions as an outwardly rectifying channel. It is expressed primarily in neural tissues and is stimulated by membrane stretch and polyunsaturated fatty acids.[3]


See also


  1. ^ Lesage F, Maingret F, Lazdunski M (May 2000). "Cloning and expression of human TRAAK, a polyunsaturated fatty acids-activated and mechano-sensitive K(+) channel". FEBS Lett 471 (2-3): 137-40. PMID 10767409.  
  2. ^ Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev 57 (4): 527-40. doi:10.1124/pr.57.4.12. PMID 16382106.  
  3. ^ a b "Entrez Gene: KCNK4 potassium channel, subfamily K, member 4".  

Further reading

  • Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (2001). "Potassium leak channels and the KCNK family of two-P-domain subunits.". Nat. Rev. Neurosci. 2 (3): 175–84. doi:10.1038/35058574. PMID 11256078.  
  • Chapman CG, Meadows HJ, Godden RJ, et al. (2001). "Cloning, localisation and functional expression of a novel human, cerebellum specific, two pore domain potassium channel.". Brain Res. Mol. Brain Res. 82 (1-2): 74–83. doi:10.1016/S0169-328X(00)00183-2. PMID 11042359.  
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMID 11076863.  
  • Meadows HJ, Chapman CG, Duckworth DM, et al. (2001). "The neuroprotective agent sipatrigine (BW619C89) potently inhibits the human tandem pore-domain K(+) channels TREK-1 and TRAAK.". Brain Res. 892 (1): 94–101. doi:10.1016/S0006-8993(00)03239-X. PMID 11172753.  
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.  
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614.  
  • Ozaita A, Vega-Saenz de Miera E (2003). "Cloning of two transcripts, HKT4.1a and HKT4.1b, from the human two-pore K+ channel gene KCNK4. Chromosomal localization, tissue distribution and functional expression.". Brain Res. Mol. Brain Res. 102 (1-2): 18–27. doi:10.1016/S0169-328X(02)00157-2. PMID 12191490.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance.". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMID 14759258.  
  • Harinath S, Sikdar SK (2004). "Trichloroethanol enhances the activity of recombinant human TREK-1 and TRAAK channels.". Neuropharmacology 46 (5): 750–60. doi:10.1016/j.neuropharm.2003.11.023. PMID 14996553.  
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.  
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.  
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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