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potassium channel, subfamily K, member 7
Identifiers
Symbols KCNK7; MGC118784; TWIK3; MGC118782
External IDs OMIM603940 MGI1341841 HomoloGene43131 IUPHAR: K2P7.1 GeneCards: KCNK7 Gene
Orthologs
Species Human Mouse
Entrez 10089 16530
Ensembl ENSG00000173338 ENSMUSG00000024936
UniProt n/a n/a
RefSeq (mRNA) NM_033455 NM_001004138
RefSeq (protein) NP_203133 NP_001004138
Location (UCSC) Chr 11:
65.12 - 65.12 Mb
Chr 19:
5.7 - 5.71 Mb
PubMed search [1] [2]

Potassium channel, subfamily K, member 7, also known as KCNK7 or K2P7.1 is a protein which in humans is encoded by the KCNK7 gene. K2P7.1 is a potassium channel containing two pore-forming P domains.[1][2][3] Multiple transcript variants encoding different isoforms have been found for this gene.[4]

Contents

Function

This gene encodes a member of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel; however, it may require other non-pore-forming proteins for activity.[4]

See also

References

  1. ^ Salinas M, Reyes R, Lesage F, Fosset M, Heurteaux C, Romey G, Lazdunski M (April 1999). "Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure". J. Biol. Chem. 274 (17): 11751–60. doi:10.1074/jbc.274.17.11751. PMID 10206991.  
  2. ^ Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (March 2001). "Potassium leak channels and the KCNK family of two-P-domain subunits". Nat. Rev. Neurosci. 2 (3): 175–84. doi:10.1038/35058574. PMID 11256078.  
  3. ^ Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (December 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol. Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106.  
  4. ^ a b "Entrez Gene: potassium channel". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10089.  

Further reading

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (2001). "Potassium leak channels and the KCNK family of two-P-domain subunits.". Nat. Rev. Neurosci. 2 (3): 175-84. PMID 11256078.  
  • Salinas M, Reyes R, Lesage F, et al. (1999). "Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure.". J. Biol. Chem. 274 (17): 11751-60. PMID 10206991.  
  • Medhurst AD, Rennie G, Chapman CG, et al. (2001). "Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery.". Brain Res. Mol. Brain Res. 86 (1-2): 101-14. PMID 11165377.  

External links

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