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Potassium channel, subfamily K, member 9
Identifiers
Symbols KCNK9; K2p9.1; KT3.2; MGC138268; MGC138270; TASK-3; TASK3
External IDs OMIM605874 MGI3521816 HomoloGene56758 IUPHAR: K2P9.1 GeneCards: KCNK9 Gene
RNA expression pattern
PBB GE KCNK9 gnf1h00252 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 51305 223604
Ensembl ENSG00000169427 ENSMUSG00000036760
UniProt Q9NPC2 Q3LS21
RefSeq (mRNA) NM_016601 NM_001033876
RefSeq (protein) NP_057685 NP_001029048
Location (UCSC) Chr 8:
140.69 - 140.78 Mb
Chr 15:
72.34 - 72.37 Mb
PubMed search [1] [2]

Potassium channel subfamily K member 9 is a protein that in humans is encoded by the KCNK9 gene.[1][2][3]

This gene encodes K2P9.1, one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This open channel is highly expressed in the cerebellum. It is inhibited by extracellular acidification and arachidonic acid, and strongly inhibited by phorbol 12-myristate 13-acetate.[3]

Contents

See also

References

  1. ^ Kim Y, Bang H, Kim D (May 2000). "TASK-3, a new member of the tandem pore K(+) channel family". J Biol Chem 275 (13): 9340-7. PMID 10734076.  
  2. ^ Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev 57 (4): 527-40. doi:10.1124/pr.57.4.12. PMID 16382106.  
  3. ^ a b "Entrez Gene: KCNK9 potassium channel, subfamily K, member 9". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51305.  

Further reading

  • Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (2001). "Potassium leak channels and the KCNK family of two-P-domain subunits.". Nat. Rev. Neurosci. 2 (3): 175–84. doi:10.1038/35058574. PMID 11256078.  
  • Rajan S, Wischmeyer E, Xin Liu G, et al. (2000). "TASK-3, a novel tandem pore domain acid-sensitive K+ channel. An extracellular histiding as pH sensor.". J. Biol. Chem. 275 (22): 16650–7. doi:10.1074/jbc.M000030200. PMID 10747866.  
  • Chapman CG, Meadows HJ, Godden RJ, et al. (2001). "Cloning, localisation and functional expression of a novel human, cerebellum specific, two pore domain potassium channel.". Brain Res. Mol. Brain Res. 82 (1-2): 74–83. doi:10.1016/S0169-328X(00)00183-2. PMID 11042359.  
  • Vega-Saenz de Miera E, Lau DH, Zhadina M, et al. (2001). "KT3.2 and KT3.3, two novel human two-pore K(+) channels closely related to TASK-1.". J. Neurophysiol. 86 (1): 130–42. PMID 11431495.  
  • Talley EM, Bayliss DA (2002). "Modulation of TASK-1 (Kcnk3) and TASK-3 (Kcnk9) potassium channels: volatile anesthetics and neurotransmitters share a molecular site of action.". J. Biol. Chem. 277 (20): 17733–42. doi:10.1074/jbc.M200502200. PMID 11886861.  
  • Rajan S, Preisig-Müller R, Wischmeyer E, et al. (2003). "Interaction with 14-3-3 proteins promotes functional expression of the potassium channels TASK-1 and TASK-3.". J. Physiol. (Lond.) 545 (Pt 1): 13–26. doi:10.1113/jphysiol.2002.027052. PMID 12433946.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Mu D, Chen L, Zhang X, et al. (2003). "Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene.". Cancer Cell 3 (3): 297–302. doi:10.1016/S1535-6108(03)00054-0. PMID 12676587.  
  • Pei L, Wiser O, Slavin A, et al. (2003). "Oncogenic potential of TASK3 (Kcnk9) depends on K+ channel function.". Proc. Natl. Acad. Sci. U.S.A. 100 (13): 7803–7. doi:10.1073/pnas.1232448100. PMID 12782791.  
  • Rusznák Z, Pocsai K, Kovács I, et al. (2004). "Differential distribution of TASK-1, TASK-2 and TASK-3 immunoreactivities in the rat and human cerebellum.". Cell. Mol. Life Sci. 61 (12): 1532–42. doi:10.1007/s00018-004-4082-3. PMID 15197476.  
  • Clarke CE, Veale EL, Green PJ, et al. (2005). "Selective block of the human 2-P domain potassium channel, TASK-3, and the native leak potassium current, IKSO, by zinc.". J. Physiol. (Lond.) 560 (Pt 1): 51–62. doi:10.1113/jphysiol.2004.070292. PMID 15284350.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Kim CJ, Cho YG, Jeong SW, et al. (2005). "Altered expression of KCNK9 in colorectal cancers.". APMIS 112 (9): 588–94. doi:10.1111/j.1600-0463.2004.apm1120905.x. PMID 15601307.  
  • Pocsai K, Kosztka L, Bakondi G, et al. (2006). "Melanoma cells exhibit strong intracellular TASK-3-specific immunopositivity in both tissue sections and cell culture.". Cell. Mol. Life Sci. 63 (19-20): 2364–76. doi:10.1007/s00018-006-6166-8. PMID 17013562.  
  • Zuzarte M, Rinné S, Schlichthörl G, et al. (2007). "A di-acidic sequence motif enhances the surface expression of the potassium channel TASK-3.". Traffic 8 (8): 1093–100. doi:10.1111/j.1600-0854.2007.00593.x. PMID 17547699.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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