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Potassium large conductance calcium-activated channel, subfamily M, beta member 1
Symbols KCNMB1; K(VCA)beta; SLO-BETA; hslo-beta
External IDs OMIM603951 MGI1334203 HomoloGene3054 GeneCards: KCNMB1 Gene
RNA expression pattern
PBB GE KCNMB1 209948 at tn.png
More reference expression data
Species Human Mouse
Entrez 3779 16533
Ensembl ENSG00000145936 ENSMUSG00000020155
UniProt Q16558 Q5SQK1
RefSeq (mRNA) NM_004137 NM_031169
RefSeq (protein) NP_004128 NP_112446
Location (UCSC) Chr 5:
169.74 - 169.75 Mb
Chr 11:
33.86 - 33.87 Mb
PubMed search [1] [2]

Calcium-activated potassium channel subunit beta-1 is a protein that in humans is encoded by the KCNMB1 gene.[1][2][3]

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the product of this gene, the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits.[3]

See also


  1. ^ Tseng-Crank J, Godinot N, Johansen TE, Ahring PK, Strobaek D, Mertz R, Foster CD, Olesen SP, Reinhart PH (Oct 1996). "Cloning, expression, and distribution of a Ca(2+)-activated K+ channel beta-subunit from human brain". Proc Natl Acad Sci U S A 93 (17): 9200-5. PMID 8799178.  
  2. ^ Jiang Z, Wallner M, Meera P, Toro L (Mar 1999). "Human and rodent MaxiK channel beta-subunit genes: cloning and characterization". Genomics 55 (1): 57-67. doi:10.1006/geno.1998.5627. PMID 9888999.  
  3. ^ a b "Entrez Gene: KCNMB1 potassium large conductance calcium-activated channel, subfamily M, beta member 1".  

Further reading

  • Orio P, Rojas P, Ferreira G, Latorre R (2002). "New disguises for an old channel: MaxiK channel beta-subunits.". News Physiol. Sci. 17: 156–61. PMID 12136044.  
  • Knaus HG, Folander K, Garcia-Calvo M, et al. (1994). "Primary sequence and immunological characterization of beta-subunit of high conductance Ca(2+)-activated K+ channel from smooth muscle.". J. Biol. Chem. 269 (25): 17274–8. PMID 8006036.  
  • Meera P, Wallner M, Jiang Z, Toro L (1996). "A calcium switch for the functional coupling between alpha (hslo) and beta subunits (KV,Ca beta) of maxi K channels.". FEBS Lett. 382 (1-2): 84–8. doi:10.1016/0014-5793(96)00151-2. PMID 8612769.  
  • Dworetzky SI, Boissard CG, Lum-Ragan JT, et al. (1996). "Phenotypic alteration of a human BK (hSlo) channel by hSlobeta subunit coexpression: changes in blocker sensitivity, activation/relaxation and inactivation kinetics, and protein kinase A modulation.". J. Neurosci. 16 (15): 4543–50. PMID 8764643.  
  • Valverde MA, Rojas P, Amigo J, et al. (1999). "Acute activation of Maxi-K channels (hSlo) by estradiol binding to the beta subunit.". Science 285 (5435): 1929–31. doi:10.1126/science.285.5435.1929. PMID 10489376.  
  • Meera P, Wallner M, Toro L (2000). "A neuronal beta subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin.". Proc. Natl. Acad. Sci. U.S.A. 97 (10): 5562–7. doi:10.1073/pnas.100118597. PMID 10792058.  
  • Jin P, Weiger TM, Wu Y, Levitan IB (2002). "Phosphorylation-dependent functional coupling of hSlo calcium-dependent potassium channel and its hbeta 4 subunit.". J. Biol. Chem. 277 (12): 10014–20. doi:10.1074/jbc.M107682200. PMID 11790768.  
  • Greenwood IA, Miller LJ, Ohya S, Horowitz B (2002). "The large conductance potassium channel beta-subunit can interact with and modulate the functional properties of a calcium-activated chloride channel, CLCA1.". J. Biol. Chem. 277 (25): 22119–22. doi:10.1074/jbc.C200215200. PMID 11994272.  
  • Gollasch M, Tank J, Luft FC, et al. (2002). "The BK channel beta1 subunit gene is associated with human baroreflex and blood pressure regulation.". J. Hypertens. 20 (5): 927–33. doi:10.1097/00004872-200205000-00028. PMID 12011654.  
  • Jin P, Weiger TM, Levitan IB (2003). "Reciprocal modulation between the alpha and beta 4 subunits of hSlo calcium-dependent potassium channels.". J. Biol. Chem. 277 (46): 43724–9. doi:10.1074/jbc.M205795200. PMID 12223479.  
  • Mazzone JN, Kaiser RA, Buxton IL (2003). "Calcium-activated potassium channel expression in human myometrium: effect of pregnancy.". Proc. West. Pharmacol. Soc. 45: 184–6. PMID 12434576.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Kudlacek PE, Pluznick JL, Ma R, et al. (2003). "Role of hbeta1 in activation of human mesangial BK channels by cGMP kinase.". Am. J. Physiol. Renal Physiol. 285 (2): F289–94. doi:10.1152/ajprenal.00046.2003. PMID 12670831.  
  • Qian X, Magleby KL (2003). "Beta1 subunits facilitate gating of BK channels by acting through the Ca2+, but not the Mg2+, activating mechanisms.". Proc. Natl. Acad. Sci. U.S.A. 100 (17): 10061–6. doi:10.1073/pnas.1731650100. PMID 12893878.  
  • Ransom CB, Liu X, Sontheimer H (2004). "Current transients associated with BK channels in human glioma cells.". J. Membr. Biol. 193 (3): 201–13. doi:10.1007/s00232-003-2019-7. PMID 12962281.  
  • Hartness ME, Brazier SP, Peers C, et al. (2004). "Post-transcriptional control of human maxiK potassium channel activity and acute oxygen sensitivity by chronic hypoxia.". J. Biol. Chem. 278 (51): 51422–32. doi:10.1074/jbc.M309463200. PMID 14522958.  
  • Fernández-Fernández JM, Tomás M, Vázquez E, et al. (2004). "Gain-of-function mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertension.". J. Clin. Invest. 113 (7): 1032–9. doi:10.1172/JCI200420347. PMID 15057310.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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