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Potassium large conductance calcium-activated channel, subfamily M, beta member 1
Identifiers
Symbols KCNMB1; K(VCA)beta; SLO-BETA; hslo-beta
External IDs OMIM603951 MGI1334203 HomoloGene3054 GeneCards: KCNMB1 Gene
RNA expression pattern
PBB GE KCNMB1 209948 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3779 16533
Ensembl ENSG00000145936 ENSMUSG00000020155
UniProt Q16558 Q5SQK1
RefSeq (mRNA) NM_004137 NM_031169
RefSeq (protein) NP_004128 NP_112446
Location (UCSC) Chr 5:
169.74 - 169.75 Mb
Chr 11:
33.86 - 33.87 Mb
PubMed search [1] [2]

Calcium-activated potassium channel subunit beta-1 is a protein that in humans is encoded by the KCNMB1 gene.[1][2][3]

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the product of this gene, the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits.[3]

See also

References

  1. ^ Tseng-Crank J, Godinot N, Johansen TE, Ahring PK, Strobaek D, Mertz R, Foster CD, Olesen SP, Reinhart PH (Oct 1996). "Cloning, expression, and distribution of a Ca(2+)-activated K+ channel beta-subunit from human brain". Proc Natl Acad Sci U S A 93 (17): 9200-5. PMID 8799178.  
  2. ^ Jiang Z, Wallner M, Meera P, Toro L (Mar 1999). "Human and rodent MaxiK channel beta-subunit genes: cloning and characterization". Genomics 55 (1): 57-67. doi:10.1006/geno.1998.5627. PMID 9888999.  
  3. ^ a b "Entrez Gene: KCNMB1 potassium large conductance calcium-activated channel, subfamily M, beta member 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3779.  

Further reading

  • Orio P, Rojas P, Ferreira G, Latorre R (2002). "New disguises for an old channel: MaxiK channel beta-subunits.". News Physiol. Sci. 17: 156–61. PMID 12136044.  
  • Knaus HG, Folander K, Garcia-Calvo M, et al. (1994). "Primary sequence and immunological characterization of beta-subunit of high conductance Ca(2+)-activated K+ channel from smooth muscle.". J. Biol. Chem. 269 (25): 17274–8. PMID 8006036.  
  • Meera P, Wallner M, Jiang Z, Toro L (1996). "A calcium switch for the functional coupling between alpha (hslo) and beta subunits (KV,Ca beta) of maxi K channels.". FEBS Lett. 382 (1-2): 84–8. doi:10.1016/0014-5793(96)00151-2. PMID 8612769.  
  • Dworetzky SI, Boissard CG, Lum-Ragan JT, et al. (1996). "Phenotypic alteration of a human BK (hSlo) channel by hSlobeta subunit coexpression: changes in blocker sensitivity, activation/relaxation and inactivation kinetics, and protein kinase A modulation.". J. Neurosci. 16 (15): 4543–50. PMID 8764643.  
  • Valverde MA, Rojas P, Amigo J, et al. (1999). "Acute activation of Maxi-K channels (hSlo) by estradiol binding to the beta subunit.". Science 285 (5435): 1929–31. doi:10.1126/science.285.5435.1929. PMID 10489376.  
  • Meera P, Wallner M, Toro L (2000). "A neuronal beta subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin.". Proc. Natl. Acad. Sci. U.S.A. 97 (10): 5562–7. doi:10.1073/pnas.100118597. PMID 10792058.  
  • Jin P, Weiger TM, Wu Y, Levitan IB (2002). "Phosphorylation-dependent functional coupling of hSlo calcium-dependent potassium channel and its hbeta 4 subunit.". J. Biol. Chem. 277 (12): 10014–20. doi:10.1074/jbc.M107682200. PMID 11790768.  
  • Greenwood IA, Miller LJ, Ohya S, Horowitz B (2002). "The large conductance potassium channel beta-subunit can interact with and modulate the functional properties of a calcium-activated chloride channel, CLCA1.". J. Biol. Chem. 277 (25): 22119–22. doi:10.1074/jbc.C200215200. PMID 11994272.  
  • Gollasch M, Tank J, Luft FC, et al. (2002). "The BK channel beta1 subunit gene is associated with human baroreflex and blood pressure regulation.". J. Hypertens. 20 (5): 927–33. doi:10.1097/00004872-200205000-00028. PMID 12011654.  
  • Jin P, Weiger TM, Levitan IB (2003). "Reciprocal modulation between the alpha and beta 4 subunits of hSlo calcium-dependent potassium channels.". J. Biol. Chem. 277 (46): 43724–9. doi:10.1074/jbc.M205795200. PMID 12223479.  
  • Mazzone JN, Kaiser RA, Buxton IL (2003). "Calcium-activated potassium channel expression in human myometrium: effect of pregnancy.". Proc. West. Pharmacol. Soc. 45: 184–6. PMID 12434576.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Kudlacek PE, Pluznick JL, Ma R, et al. (2003). "Role of hbeta1 in activation of human mesangial BK channels by cGMP kinase.". Am. J. Physiol. Renal Physiol. 285 (2): F289–94. doi:10.1152/ajprenal.00046.2003. PMID 12670831.  
  • Qian X, Magleby KL (2003). "Beta1 subunits facilitate gating of BK channels by acting through the Ca2+, but not the Mg2+, activating mechanisms.". Proc. Natl. Acad. Sci. U.S.A. 100 (17): 10061–6. doi:10.1073/pnas.1731650100. PMID 12893878.  
  • Ransom CB, Liu X, Sontheimer H (2004). "Current transients associated with BK channels in human glioma cells.". J. Membr. Biol. 193 (3): 201–13. doi:10.1007/s00232-003-2019-7. PMID 12962281.  
  • Hartness ME, Brazier SP, Peers C, et al. (2004). "Post-transcriptional control of human maxiK potassium channel activity and acute oxygen sensitivity by chronic hypoxia.". J. Biol. Chem. 278 (51): 51422–32. doi:10.1074/jbc.M309463200. PMID 14522958.  
  • Fernández-Fernández JM, Tomás M, Vázquez E, et al. (2004). "Gain-of-function mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertension.". J. Clin. Invest. 113 (7): 1032–9. doi:10.1172/JCI200420347. PMID 15057310.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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