The Full Wiki

More info on KCNQ4

KCNQ4: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

edit
Potassium voltage-gated channel, KQT-like subfamily, member 4

PDB rendering based on 2ovc.
Available structures
2ovc
Identifiers
Symbols KCNQ4; DFNA2; KV7.4
External IDs OMIM603537 MGI1926803 HomoloGene78107 IUPHAR: Kv7.4 GeneCards: KCNQ4 Gene
RNA expression pattern
PBB GE KCNQ4 221083 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9132 60613
Ensembl ENSG00000117013 ENSMUSG00000028631
UniProt P56696 Q9JK97
RefSeq (mRNA) XM_001132376 XM_143960
RefSeq (protein) XP_001132376 XP_143960
Location (UCSC) Chr 1:
41.02 - 41.08 Mb
Chr 4:
120.2 - 120.24 Mb
PubMed search [1] [2]

Potassium voltage-gated channel subfamily KQT member 4 is a protein that in humans is encoded by the KCNQ4 gene.[1][2][3]

The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene.[3]

Contents

See also

References

  1. ^ Kubisch C, Schroeder BC, Friedrich T, Lutjohann B, El-Amraoui A, Marlin S, Petit C, Jentsch TJ (Mar 1999). "KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness". Cell 96 (3): 437–46. doi:10.1016/S0092-8674(00)80556-5. PMID 10025409.  
  2. ^ Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104.  
  3. ^ a b "Entrez Gene: KCNQ4 potassium voltage-gated channel, KQT-like subfamily, member 4". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9132.  

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message