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potassium channel, subfamily U, member 1
Identifiers
Symbols KCNU1; Kcnma3; Slo3; KCNMC1; KCa5
External IDs MGI1202300 HomoloGene7392 IUPHAR: KCa5.1 GeneCards: KCNU1 Gene
Orthologs
Species Human Mouse
Entrez 157855 16532
Ensembl ENSG00000215262 ENSMUSG00000031576
UniProt A8MYU2 O54982
RefSeq (mRNA) NM_001031836 NM_008432
RefSeq (protein) NP_001027006 NP_032458
Location (UCSC) Chr 8:
36.64 - 36.79 Mb
Chr 8:
26.96 - 27.05 Mb
PubMed search [1] [2]

Potassium channel, subfamily U, member 1, also known as KCNU1, is a gene encoding the KCa5.1 protein.[1].

Although this channel is structurally related to the calcium-activated potassium channels, it cannot be classified as such since it is activated by high intracellular pH and relatively insensitive to changes in calcium concentrations.[2][3][4]

References

  1. ^ Schreiber M, Wei A, Yuan A, Gaut J, Saito M, Salkoff L (February 1998). "Slo3, a novel pH-sensitive K+ channel from mammalian spermatocytes". J. Biol. Chem. 273 (6): 3509–16. doi:10.1074/jbc.273.6.3509. PMID 9452476.  
  2. ^ Wei AD, Gutman GA, Aldrich R, Chandy KG, Grissmer S, Wulff H (2005). "International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels.". Pharmacol Rev 57 (4): 463–72. doi:10.1124/pr.57.4.9. PMID 16382103.  
  3. ^ Zhang X, Zeng X, Xia XM, Lingle CJ (September 2006). "pH-regulated Slo3 K+ channels: properties of unitary currents". J. Gen. Physiol. 128 (3): 301–15. doi:10.1085/jgp.200609551. PMID 16940554.  
  4. ^ Zhang X, Zeng X, Lingle CJ (September 2006). "Slo3 K+ channels: voltage and pH dependence of macroscopic currents". J. Gen. Physiol. 128 (3): 317–36. doi:10.1085/jgp.200609552. PMID 16940555.  

Further reading

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.  
  • Schreiber M, Wei A, Yuan A, et al. (1998). "Slo3, a novel pH-sensitive K+ channel from mammalian spermatocytes.". J. Biol. Chem. 273 (6): 3509-16. PMID 9452476.  
  • Nusbaum C, Mikkelsen TS, Zody MC, et al. (2006). "DNA sequence and analysis of human chromosome 8.". Nature 439 (7074): 331-5. doi:10.1038/nature04406. PMID 16421571.  
  • Wei AD, Gutman GA, Aldrich R, et al. (2005). "International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels.". Pharmacol. Rev. 57 (4): 463-72. doi:10.1124/pr.57.4.9. PMID 16382103.  
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