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Kruppel-like factor 11
Identifiers
Symbols KLF11; FKLF; FKLF1; MODY7; TIEG2; Tieg3
External IDs OMIM603301 MGI2653368 HomoloGene2668 GeneCards: KLF11 Gene
RNA expression pattern
PBB GE KLF11 218486 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8462 194655
Ensembl ENSG00000172059 ENSMUSG00000020653
UniProt O14901 Q8BHJ1
RefSeq (mRNA) XM_001129527 NM_178357
RefSeq (protein) XP_001129527 NP_848134
Location (UCSC) Chr 2:
10.1 - 10.11 Mb
Chr 12:
25.24 - 25.25 Mb
PubMed search [1] [2]

Krueppel-like factor 11 is a protein that in humans is encoded by the KLF11 gene.[1][2][3]

Contents

Interactions

KLF11 has been shown to interact with SIN3A.[4][5]

See also

References

  1. ^ Cook T, Gebelein B, Mesa K, Mladek A, Urrutia R (Nov 1998). "Molecular cloning and characterization of TIEG2 reveals a new subfamily of transforming growth factor-beta-inducible Sp1-like zinc finger-encoding genes involved in the regulation of cell growth". J Biol Chem 273 (40): 25929–36. PMID 9748269.  
  2. ^ Scohy S, Gabant P, Van Reeth T, Hertveldt V, Dreze PL, Van Vooren P, Riviere M, Szpirer J, Szpirer C (Jan 2001). "Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family". Genomics 70 (1): 93–101. doi:10.1006/geno.2000.6362. PMID 11087666.  
  3. ^ "Entrez Gene: KLF11 Kruppel-like factor 11". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8462.  
  4. ^ Zhang, J S; Moncrieffe M C, Kaczynski J, Ellenrieder V, Prendergast F G, Urrutia R (Aug. 2001). "A conserved alpha-helical motif mediates the interaction of Sp1-like transcriptional repressors with the corepressor mSin3A". Mol. Cell. Biol. (United States) 21 (15): 5041–9. doi:10.1128/MCB.21.15.5041-5049.2001. ISSN 0270-7306. PMID 11438660.  
  5. ^ Ellenrieder, Volker; Zhang Jin-San, Kaczynski Joanna, Urrutia Raul (May. 2002). "Signaling disrupts mSin3A binding to the Mad1-like Sin3-interacting domain of TIEG2, an Sp1-like repressor". EMBO J. (England) 21 (10): 2451–60. doi:10.1093/emboj/21.10.2451. ISSN 0261-4189. PMID 12006497.  

Further reading

  • Asano H, Li XS, Stamatoyannopoulos G (1999). "FKLF, a novel Krüppel-like factor that activates human embryonic and fetal beta-like globin genes.". Mol. Cell. Biol. 19 (5): 3571–9. PMID 10207080.  
  • Zhang JS, Moncrieffe MC, Kaczynski J, et al. (2001). "A conserved alpha-helical motif mediates the interaction of Sp1-like transcriptional repressors with the corepressor mSin3A.". Mol. Cell. Biol. 21 (15): 5041–9. doi:10.1128/MCB.21.15.5041-5049.2001. PMID 11438660.  
  • Jia L, Young MF, Powell J, et al. (2002). "Gene expression profile of human bone marrow stromal cells: high-throughput expressed sequence tag sequencing analysis.". Genomics 79 (1): 7–17. doi:10.1006/geno.2001.6683. PMID 11827452.  
  • Ellenrieder V, Zhang JS, Kaczynski J, Urrutia R (2002). "Signaling disrupts mSin3A binding to the Mad1-like Sin3-interacting domain of TIEG2, an Sp1-like repressor.". Embo J. 21 (10): 2451–60. doi:10.1093/emboj/21.10.2451. PMID 12006497.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Ou XM, Chen K, Shih JC (2004). "Dual functions of transcription factors, transforming growth factor-beta-inducible early gene (TIEG)2 and Sp3, are mediated by CACCC element and Sp1 sites of human monoamine oxidase (MAO) B gene.". J. Biol. Chem. 279 (20): 21021–8. doi:10.1074/jbc.M312638200. PMID 15024015.  
  • Ellenrieder V, Buck A, Harth A, et al. (2004). "KLF11 mediates a critical mechanism in TGF-beta signaling that is inactivated by Erk-MAPK in pancreatic cancer cells.". Gastroenterology 127 (2): 607–20. doi:10.1053/j.gastro.2004.05.018. PMID 15300592.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Cao S, Fernandez-Zapico ME, Jin D, et al. (2005). "KLF11-mediated repression antagonizes Sp1/sterol-responsive element-binding protein-induced transcriptional activation of caveolin-1 in response to cholesterol signaling.". J. Biol. Chem. 280 (3): 1901–10. doi:10.1074/jbc.M407941200. PMID 15531587.  
  • Neve B, Fernandez-Zapico ME, Ashkenazi-Katalan V, et al. (2005). "Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function.". Proc. Natl. Acad. Sci. U.S.A. 102 (13): 4807–12. doi:10.1073/pnas.0409177102. PMID 15774581.  
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.  
  • Buck A, Buchholz M, Wagner M, et al. (2007). "The tumor suppressor KLF11 mediates a novel mechanism in transforming growth factor beta-induced growth inhibition that is inactivated in pancreatic cancer.". Mol. Cancer Res. 4 (11): 861–72. doi:10.1158/1541-7786.MCR-06-0081. PMID 17114344.  
  • Florez JC, Saxena R, Winckler W, et al. (2007). "The Krüppel-like factor 11 (KLF11) Q62R polymorphism is not associated with type 2 diabetes in 8,676 people.". Diabetes 55 (12): 3620–4. doi:10.2337/db06-0867. PMID 17130512.  
  • Spittau B, Wang Z, Boinska D, Krieglstein K (2007). "Functional domains of the TGF-beta-inducible transcription factor Tieg3 and detection of two putative nuclear localization signals within the zinc finger DNA-binding domain.". J. Cell. Biochem. 101 (3): 712–22. doi:10.1002/jcb.21228. PMID 17252542.  
  • Niu X, Perakakis N, Laubner K, et al. (2007). "Human Krüppel-like factor 11 inhibits human proinsulin promoter activity in pancreatic beta cells.". Diabetologia 50 (7): 1433–41. doi:10.1007/s00125-007-0667-3. PMID 17479246.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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