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Kruppel-like factor 12
Symbols KLF12; AP-2rep; AP2REP; HSPC122
External IDs OMIM607531 MGI1333796 HomoloGene21417 GeneCards: KLF12 Gene
RNA expression pattern
PBB GE KLF12 206966 s at tn.png
PBB GE KLF12 206965 at tn.png
PBB GE KLF12 214276 at tn.png
More reference expression data
Species Human Mouse
Entrez 11278 16597
Ensembl ENSG00000118922 ENSMUSG00000072294
UniProt Q9Y4X4 Q6NWV9
RefSeq (mRNA) NM_016285 NM_010636
RefSeq (protein) NP_057369 NP_034766
Location (UCSC) Chr 13:
73.16 - 73.61 Mb
Chr 14:
98.76 - 98.99 Mb
PubMed search [1] [2]

Krueppel-like factor 12 is a protein that in humans is encoded by the KLF12 gene.[1][2]

Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene.[2]


See also


  1. ^ Roth C, Schuierer M, Gunther K, Buettner R (Jul 2000). "Genomic structure and DNA binding properties of the human zinc finger transcriptional repressor AP-2rep (KLF12)". Genomics 63 (3): 384-90. doi:10.1006/geno.1999.6084. PMID 10704285.  
  2. ^ a b "Entrez Gene: KLF12 Kruppel-like factor 12".  

Further reading

  • Imhof A, Schuierer M, Werner O, et al. (1999). "Transcriptional regulation of the AP-2alpha promoter by BTEB-1 and AP-2rep, a novel wt-1/egr-related zinc finger repressor.". Mol. Cell. Biol. 19 (1): 194–204. PMID 9858544.  
  • Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMID 11042152.  
  • Schuierer M, Hilger-Eversheim K, Dobner T, et al. (2001). "Induction of AP-2alpha expression by adenoviral infection involves inactivation of the AP-2rep transcriptional corepressor CtBP1.". J. Biol. Chem. 276 (30): 27944–9. doi:10.1074/jbc.M100070200. PMID 11373277.  
  • Zhu CH, Huang Y, Broman MT, Domann FE (2001). "Expression of AP-2 alpha in SV40 immortalized human lung fibroblasts is associated with a distinct pattern of cytosine methylation in the AP-2 alpha promoter.". Biochim. Biophys. Acta 1519 (1-2): 85–91. PMID 11406275.  
  • Chen C, Brabham WW, Stultz BG, et al. (2001). "Defining a common region of deletion at 13q21 in human cancers.". Genes Chromosomes Cancer 31 (4): 333–44. doi:10.1002/gcc.1152. PMID 11433524.  
  • Rozenblum E, Vahteristo P, Sandberg T, et al. (2002). "A genomic map of a 6-Mb region at 13q21-q22 implicated in cancer development: identification and characterization of candidate genes.". Hum. Genet. 110 (2): 111–21. doi:10.1007/s00439-001-0646-6. PMID 11935316.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13.". Nature 428 (6982): 522–8. doi:10.1038/nature02379. PMID 15057823.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.  
  • Suda S, Rai T, Sohara E, et al. (2006). "Postnatal expression of KLF12 in the inner medullary collecting ducts of kidney and its trans-activation of UT-A1 urea transporter promoter.". Biochem. Biophys. Res. Commun. 344 (1): 246–52. doi:10.1016/j.bbrc.2006.03.138. PMID 16615998.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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