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Kruppel-like factor 13
Identifiers
Symbols KLF13; BTEB3; FKLF2; NSLP1; RFLAT-1; RFLAT1
External IDs OMIM605328 MGI1354948 HomoloGene32288 GeneCards: KLF13 Gene
RNA expression pattern
PBB GE KLF13 219878 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 51621 50794
Ensembl ENSG00000169926 ENSMUSG00000052040
UniProt Q9Y2Y9 Q3U2G6
RefSeq (mRNA) NM_015995 NM_021366
RefSeq (protein) NP_057079 NP_067341
Location (UCSC) Chr 15:
29.41 - 29.46 Mb
Chr 7:
63.77 - 63.82 Mb
PubMed search [1] [2]

Kruppel-like factor 13, also known as KLF13, is a protein which in humans is encoded by the KLF13 gene.[1][2][3]

Contents

Function

KLF13 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes.[4][1]

KLF13 was first described as the RANTES factor of late activated T lymphocytes (RFLAT)-1.[3] It regulates the expression of the chemokine RANTES in T lymphocytes. It functions as a lynchpin inducing a large enhancesome. KLF13 knock-out mice show a defect in lymphocyte survival as KLF13 is a regulator of Bcl-xL expression.[3][5][6][7][8][9][10]

Interactions

KLF13 has been shown to interact with CREB binding protein,[11] Heat shock protein 47[11] and PCAF.[11]

See also

References

  1. ^ a b "Entrez Gene: KLF13 Kruppel-like factor 13". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51621.  
  2. ^ Cook T, Gebelein B, Urrutia R (June 1999). "Sp1 and its likes: biochemical and functional predictions for a growing family of zinc finger transcription factors". Ann. N. Y. Acad. Sci. 880: 94–102. doi:10.1111/j.1749-6632.1999.tb09513.x. PMID 10415854.  
  3. ^ a b c Song A, Chen YF, Thamatrakoln K, Storm TA, Krensky AM (January 1999). "RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes". Immunity 10 (1): 93–103. doi:10.1016/S1074-7613(00)80010-2. PMID 10023774.  
  4. ^ Scohy S, Gabant P, Van Reeth T, Hertveldt V, Drèze PL, Van Vooren P, Rivière M, Szpirer J, Szpirer C (November 2000). "Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family". Genomics 70 (1): 93–101. doi:10.1006/geno.2000.6362. PMID 11087666.  
  5. ^ Song A, Nikolcheva T, Krensky AM (October 2000). "Transcriptional regulation of RANTES expression in T lymphocytes". Immunol. Rev. 177: 236–45. doi:10.1034/j.1600-065X.2000.17610.x. PMID 11138780.  
  6. ^ Nikolcheva T, Pyronnet S, Chou SY, Sonenberg N, Song A, Clayberger C, Krensky AM (July 2002). "A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes". J. Clin. Invest. 110 (1): 119–26. doi:10.1172/JCI15336. PMID 12093895.  
  7. ^ Song A, Patel A, Thamatrakoln K, Liu C, Feng D, Clayberger C, Krensky AM (August 2002). "Functional domains and DNA-binding sequences of RFLAT-1/KLF13, a Krüppel-like transcription factor of activated T lymphocytes". J. Biol. Chem. 277 (33): 30055–65. doi:10.1074/jbc.M204278200. PMID 12050170.  
  8. ^ Zhou M, McPherson L, Feng D, Song A, Dong C, Lyu SC, Zhou L, Shi X, Ahn YT, Wang D, Clayberger C, Krensky AM (May 2007). "Kruppel-like transcription factor 13 regulates T lymphocyte survival in vivo". J. Immunol. 178 (9): 5496–504. PMID 17442931. http://www.jimmunol.org/cgi/content/abstract/178/9/5496.  
  9. ^ Huang B, Ahn YT, McPherson L, Clayberger C, Krensky AM (June 2007). "Interaction of PRP4 with Kruppel-like factor 13 regulates CCL5 transcription". J. Immunol. 178 (11): 7081–7. PMID 17513757. http://www.jimmunol.org/cgi/pmidlookup?view=long&pmid=17513757.  
  10. ^ Ahn YT, Huang B, McPherson L, Clayberger C, Krensky AM (January 2007). "Dynamic interplay of transcriptional machinery and chromatin regulates "late" expression of the chemokine RANTES in T lymphocytes". Mol. Cell. Biol. 27 (1): 253–66. doi:10.1128/MCB.01071-06. PMID 17074812.  
  11. ^ a b c Song, Chao-Zhong; Keller Kimberly, Murata Ken, Asano Haruhiko, Stamatoyannopoulos George (Mar. 2002). "Functional interaction between coactivators CBP/p300, PCAF, and transcription factor FKLF2". J. Biol. Chem. (United States) 277 (9): 7029–36. doi:10.1074/jbc.M108826200. ISSN 0021-9258. PMID 11748222.  

Further reading

  • Cook T, Gebelein B, Urrutia R (1999). "Sp1 and its likes: biochemical and functional predictions for a growing family of zinc finger transcription factors.". Ann. N. Y. Acad. Sci. 880: 94–102. doi:10.1111/j.1749-6632.1999.tb09513.x. PMID 10415854.  
  • Song A, Chen YF, Thamatrakoln K, et al. (1999). "RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes.". Immunity 10 (1): 93–103. doi:10.1016/S1074-7613(00)80010-2. PMID 10023774.  
  • Asano H, Li XS, Stamatoyannopoulos G (2000). "FKLF-2: a novel Krüppel-like transcriptional factor that activates globin and other erythroid lineage genes.". Blood 95 (11): 3578–84. PMID 10828046.  
  • Scohy S, Gabant P, Van Reeth T, et al. (2001). "Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family.". Genomics 70 (1): 93–101. doi:10.1006/geno.2000.6362. PMID 11087666.  
  • Kaczynski J, Zhang JS, Ellenrieder V, et al. (2001). "The Sp1-like protein BTEB3 inhibits transcription via the basic transcription element box by interacting with mSin3A and HDAC-1 co-repressors and competing with Sp1.". J. Biol. Chem. 276 (39): 36749–56. doi:10.1074/jbc.M105831200. PMID 11477107.  
  • Song CZ, Keller K, Murata K, et al. (2002). "Functional interaction between coactivators CBP/p300, PCAF, and transcription factor FKLF2.". J. Biol. Chem. 277 (9): 7029–36. doi:10.1074/jbc.M108826200. PMID 11748222.  
  • Kaczynski JA, Conley AA, Fernandez Zapico M, et al. (2002). "Functional analysis of basic transcription element (BTE)-binding protein (BTEB) 3 and BTEB4, a novel Sp1-like protein, reveals a subfamily of transcriptional repressors for the BTE site of the cytochrome P4501A1 gene promoter.". Biochem. J. 366 (Pt 3): 873–82. doi:10.1042/BJ20020388. PMID 12036432.  
  • Song A, Patel A, Thamatrakoln K, et al. (2002). "Functional domains and DNA-binding sequences of RFLAT-1/KLF13, a Krüppel-like transcription factor of activated T lymphocytes.". J. Biol. Chem. 277 (33): 30055–65. doi:10.1074/jbc.M204278200. PMID 12050170.  
  • Nikolcheva T, Pyronnet S, Chou SY, et al. (2002). "A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes.". J. Clin. Invest. 110 (1): 119–26. PMID 12093895.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Mitsuma A, Asano H, Kinoshita T, et al. (2005). "Transcriptional regulation of FKLF-2 (KLF13) gene in erythroid cells.". Biochim. Biophys. Acta 1727 (2): 125–33. doi:10.1016/j.bbaexp.2004.12.007. PMID 15716005.  
  • Zhang P, Basu P, Redmond LC, et al. (2006). "A functional screen for Krüppel-like factors that regulate the human gamma-globin gene through the CACCC promoter element.". Blood Cells Mol. Dis. 35 (2): 227–35. doi:10.1016/j.bcmd.2005.04.009. PMID 16023392.  
  • Ahn YT, Huang B, McPherson L, et al. (2007). "Dynamic interplay of transcriptional machinery and chromatin regulates "late" expression of the chemokine RANTES in T lymphocytes.". Mol. Cell. Biol. 27 (1): 253–66. doi:10.1128/MCB.01071-06. PMID 17074812.  
  • Huang B, Ahn YT, McPherson L, et al. (2007). "Interaction of PRP4 with Kruppel-like factor 13 regulates CCL5 transcription.". J. Immunol. 178 (11): 7081–7. PMID 17513757.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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