The Full Wiki

KLF2: Wikis


Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.


From Wikipedia, the free encyclopedia

Kruppel-like factor 2 (lung)
Symbols KLF2; LKLF
External IDs OMIM602016 MGI1342772 HomoloGene7395 GeneCards: KLF2 Gene
RNA expression pattern
PBB GE KLF2 219371 s at tn.png
More reference expression data
Species Human Mouse
Entrez 10365 16598
Ensembl ENSG00000127528 ENSMUSG00000055148
UniProt Q9Y5W3 Q3V293
RefSeq (mRNA) NM_016270 XM_982078
RefSeq (protein) NP_057354 XP_987172
Location (UCSC) Chr 19:
16.3 - 16.3 Mb
Chr 8:
75.25 - 75.25 Mb
PubMed search [1] [2]

Krueppel-like factor 2 is a protein that in humans is encoded by the KLF2 gene.[1][2][3]



KLF2 has been shown to interact with WWP1.[4]

See also


  1. ^ Kozyrev SV, Hansen LL, Poltaraus AB, Domninsky DA, Kisselev LL (Jun 1999). "Structure of the human CpG-island-containing lung Kruppel-like factor (LKLF) gene and its location in chromosome 19p13.11-13 locus". FEBS Lett 448 (1): 149–52. PMID 10217429.  
  2. ^ Wani MA, Conkright MD, Jeffries S, Hughes MJ, Lingrel JB (Sep 1999). "cDNA isolation, genomic structure, regulation, and chromosomal localization of human lung Kruppel-like factor". Genomics 60 (1): 78–86. doi:10.1006/geno.1999.5888. PMID 10458913.  
  3. ^ "Entrez Gene: KLF2 Kruppel-like factor 2 (lung)".  
  4. ^ Conkright, M D; Wani M A, Lingrel J B (Aug. 2001). "Lung Krüppel-like factor contains an autoinhibitory domain that regulates its transcriptional activation by binding WWP1, an E3 ubiquitin ligase". J. Biol. Chem. (United States) 276 (31): 29299–306. doi:10.1074/jbc.M103670200. ISSN 0021-9258. PMID 11375995.  

Further reading

  • Anderson KP, Kern CB, Crable SC, Lingrel JB (1995). "Isolation of a gene encoding a functional zinc finger protein homologous to erythroid Krüppel-like factor: identification of a new multigene family.". Mol. Cell. Biol. 15 (11): 5957–65. PMID 7565748.  
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  
  • Conkright MD, Wani MA, Lingrel JB (2001). "Lung Krüppel-like factor contains an autoinhibitory domain that regulates its transcriptional activation by binding WWP1, an E3 ubiquitin ligase.". J. Biol. Chem. 276 (31): 29299–306. doi:10.1074/jbc.M103670200. PMID 11375995.  
  • Denkinger DJ, Cushman-Vokoun AM, Kawahara RS (2002). "Regulation of the vav proto-oncogene by LKLF.". Gene 281 (1-2): 133–42. doi:10.1016/S0378-1119(01)00792-2. PMID 11750135.  
  • Dekker RJ, van Soest S, Fontijn RD, et al. (2002). "Prolonged fluid shear stress induces a distinct set of endothelial cell genes, most specifically lung Krüppel-like factor (KLF2).". Blood 100 (5): 1689–98. doi:10.1182/blood-2002-01-0046. PMID 12176889.  
  • Banerjee SS, Feinberg MW, Watanabe M, et al. (2003). "The Krüppel-like factor KLF2 inhibits peroxisome proliferator-activated receptor-gamma expression and adipogenesis.". J. Biol. Chem. 278 (4): 2581–4. doi:10.1074/jbc.M210859200. PMID 12426306.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • SenBanerjee S, Lin Z, Atkins GB, et al. (2004). "KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activation.". J. Exp. Med. 199 (10): 1305–15. doi:10.1084/jem.20031132. PMID 15136591.  
  • Haaland RE, Yu W, Rice AP (2005). "Identification of LKLF-regulated genes in quiescent CD4+ T lymphocytes.". Mol. Immunol. 42 (5): 627–41. doi:10.1016/j.molimm.2004.09.012. PMID 15607822.  
  • Lin Z, Kumar A, SenBanerjee S, et al. (2005). "Kruppel-like factor 2 (KLF2) regulates endothelial thrombotic function.". Circ. Res. 96 (5): e48–57. doi:10.1161/01.RES.0000159707.05637.a1. PMID 15718498.  
  • Wang F, Zhu Y, Huang Y, et al. (2005). "Transcriptional repression of WEE1 by Kruppel-like factor 2 is involved in DNA damage-induced apoptosis.". Oncogene 24 (24): 3875–85. doi:10.1038/sj.onc.1208546. PMID 15735666.  
  • Huddleson JP, Ahmad N, Srinivasan S, Lingrel JB (2005). "Induction of KLF2 by fluid shear stress requires a novel promoter element activated by a phosphatidylinositol 3-kinase-dependent chromatin-remodeling pathway.". J. Biol. Chem. 280 (24): 23371–9. doi:10.1074/jbc.M413839200. PMID 15834135.  
  • Parmar KM, Nambudiri V, Dai G, et al. (2005). "Statins exert endothelial atheroprotective effects via the KLF2 transcription factor.". J. Biol. Chem. 280 (29): 26714–9. doi:10.1074/jbc.C500144200. PMID 15878865.  
  • Basu P, Morris PE, Haar JL, et al. (2005). "KLF2 is essential for primitive erythropoiesis and regulates the human and murine embryonic beta-like globin genes in vivo.". Blood 106 (7): 2566–71. doi:10.1182/blood-2005-02-0674. PMID 15947087.  
  • Bhattacharya R, Senbanerjee S, Lin Z, et al. (2005). "Inhibition of vascular permeability factor/vascular endothelial growth factor-mediated angiogenesis by the Kruppel-like factor KLF2.". J. Biol. Chem. 280 (32): 28848–51. doi:10.1074/jbc.C500200200. PMID 15980434.  
  • Zhang P, Basu P, Redmond LC, et al. (2006). "A functional screen for Krüppel-like factors that regulate the human gamma-globin gene through the CACCC promoter element.". Blood Cells Mol. Dis. 35 (2): 227–35. doi:10.1016/j.bcmd.2005.04.009. PMID 16023392.  
  • Sen-Banerjee S, Mir S, Lin Z, et al. (2006). "Kruppel-like factor 2 as a novel mediator of statin effects in endothelial cells.". Circulation 112 (5): 720–6. doi:10.1161/CIRCULATIONAHA.104.525774. PMID 16043642.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



Got something to say? Make a comment.
Your name
Your email address