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Kruppel-like factor 2 (lung)
Identifiers
Symbols KLF2; LKLF
External IDs OMIM602016 MGI1342772 HomoloGene7395 GeneCards: KLF2 Gene
RNA expression pattern
PBB GE KLF2 219371 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10365 16598
Ensembl ENSG00000127528 ENSMUSG00000055148
UniProt Q9Y5W3 Q3V293
RefSeq (mRNA) NM_016270 XM_982078
RefSeq (protein) NP_057354 XP_987172
Location (UCSC) Chr 19:
16.3 - 16.3 Mb
Chr 8:
75.25 - 75.25 Mb
PubMed search [1] [2]

Krueppel-like factor 2 is a protein that in humans is encoded by the KLF2 gene.[1][2][3]

Contents

Interactions

KLF2 has been shown to interact with WWP1.[4]

See also

References

  1. ^ Kozyrev SV, Hansen LL, Poltaraus AB, Domninsky DA, Kisselev LL (Jun 1999). "Structure of the human CpG-island-containing lung Kruppel-like factor (LKLF) gene and its location in chromosome 19p13.11-13 locus". FEBS Lett 448 (1): 149–52. PMID 10217429.  
  2. ^ Wani MA, Conkright MD, Jeffries S, Hughes MJ, Lingrel JB (Sep 1999). "cDNA isolation, genomic structure, regulation, and chromosomal localization of human lung Kruppel-like factor". Genomics 60 (1): 78–86. doi:10.1006/geno.1999.5888. PMID 10458913.  
  3. ^ "Entrez Gene: KLF2 Kruppel-like factor 2 (lung)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10365.  
  4. ^ Conkright, M D; Wani M A, Lingrel J B (Aug. 2001). "Lung Krüppel-like factor contains an autoinhibitory domain that regulates its transcriptional activation by binding WWP1, an E3 ubiquitin ligase". J. Biol. Chem. (United States) 276 (31): 29299–306. doi:10.1074/jbc.M103670200. ISSN 0021-9258. PMID 11375995.  

Further reading

  • Anderson KP, Kern CB, Crable SC, Lingrel JB (1995). "Isolation of a gene encoding a functional zinc finger protein homologous to erythroid Krüppel-like factor: identification of a new multigene family.". Mol. Cell. Biol. 15 (11): 5957–65. PMID 7565748.  
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  
  • Conkright MD, Wani MA, Lingrel JB (2001). "Lung Krüppel-like factor contains an autoinhibitory domain that regulates its transcriptional activation by binding WWP1, an E3 ubiquitin ligase.". J. Biol. Chem. 276 (31): 29299–306. doi:10.1074/jbc.M103670200. PMID 11375995.  
  • Denkinger DJ, Cushman-Vokoun AM, Kawahara RS (2002). "Regulation of the vav proto-oncogene by LKLF.". Gene 281 (1-2): 133–42. doi:10.1016/S0378-1119(01)00792-2. PMID 11750135.  
  • Dekker RJ, van Soest S, Fontijn RD, et al. (2002). "Prolonged fluid shear stress induces a distinct set of endothelial cell genes, most specifically lung Krüppel-like factor (KLF2).". Blood 100 (5): 1689–98. doi:10.1182/blood-2002-01-0046. PMID 12176889.  
  • Banerjee SS, Feinberg MW, Watanabe M, et al. (2003). "The Krüppel-like factor KLF2 inhibits peroxisome proliferator-activated receptor-gamma expression and adipogenesis.". J. Biol. Chem. 278 (4): 2581–4. doi:10.1074/jbc.M210859200. PMID 12426306.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • SenBanerjee S, Lin Z, Atkins GB, et al. (2004). "KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activation.". J. Exp. Med. 199 (10): 1305–15. doi:10.1084/jem.20031132. PMID 15136591.  
  • Haaland RE, Yu W, Rice AP (2005). "Identification of LKLF-regulated genes in quiescent CD4+ T lymphocytes.". Mol. Immunol. 42 (5): 627–41. doi:10.1016/j.molimm.2004.09.012. PMID 15607822.  
  • Lin Z, Kumar A, SenBanerjee S, et al. (2005). "Kruppel-like factor 2 (KLF2) regulates endothelial thrombotic function.". Circ. Res. 96 (5): e48–57. doi:10.1161/01.RES.0000159707.05637.a1. PMID 15718498.  
  • Wang F, Zhu Y, Huang Y, et al. (2005). "Transcriptional repression of WEE1 by Kruppel-like factor 2 is involved in DNA damage-induced apoptosis.". Oncogene 24 (24): 3875–85. doi:10.1038/sj.onc.1208546. PMID 15735666.  
  • Huddleson JP, Ahmad N, Srinivasan S, Lingrel JB (2005). "Induction of KLF2 by fluid shear stress requires a novel promoter element activated by a phosphatidylinositol 3-kinase-dependent chromatin-remodeling pathway.". J. Biol. Chem. 280 (24): 23371–9. doi:10.1074/jbc.M413839200. PMID 15834135.  
  • Parmar KM, Nambudiri V, Dai G, et al. (2005). "Statins exert endothelial atheroprotective effects via the KLF2 transcription factor.". J. Biol. Chem. 280 (29): 26714–9. doi:10.1074/jbc.C500144200. PMID 15878865.  
  • Basu P, Morris PE, Haar JL, et al. (2005). "KLF2 is essential for primitive erythropoiesis and regulates the human and murine embryonic beta-like globin genes in vivo.". Blood 106 (7): 2566–71. doi:10.1182/blood-2005-02-0674. PMID 15947087.  
  • Bhattacharya R, Senbanerjee S, Lin Z, et al. (2005). "Inhibition of vascular permeability factor/vascular endothelial growth factor-mediated angiogenesis by the Kruppel-like factor KLF2.". J. Biol. Chem. 280 (32): 28848–51. doi:10.1074/jbc.C500200200. PMID 15980434.  
  • Zhang P, Basu P, Redmond LC, et al. (2006). "A functional screen for Krüppel-like factors that regulate the human gamma-globin gene through the CACCC promoter element.". Blood Cells Mol. Dis. 35 (2): 227–35. doi:10.1016/j.bcmd.2005.04.009. PMID 16023392.  
  • Sen-Banerjee S, Mir S, Lin Z, et al. (2006). "Kruppel-like factor 2 as a novel mediator of statin effects in endothelial cells.". Circulation 112 (5): 720–6. doi:10.1161/CIRCULATIONAHA.104.525774. PMID 16043642.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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