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From Wikipedia, the free encyclopedia

Kruppel-like factor 3 (basic)

PDB rendering based on 1p7a.
Available structures
1p7a, 1u85, 1u86
Symbols KLF3; BKLF; MGC48279
External IDs OMIM609392 MGI1342773 HomoloGene7396 GeneCards: KLF3 Gene
RNA expression pattern
PBB GE KLF3 219657 s at tn.png
More reference expression data
Species Human Mouse
Entrez 51274 16599
Ensembl ENSG00000109787 ENSMUSG00000029178
UniProt P57682 Q545J5
RefSeq (mRNA) NM_016531 XM_994052
RefSeq (protein) NP_057615 XP_999146
Location (UCSC) Chr 4:
38.34 - 38.38 Mb
Chr 5:
65.08 - 65.11 Mb
PubMed search [1] [2]

Krueppel-like factor 3 is a protein that in humans is encoded by the KLF3 gene.[1][2]



KLF3 has been shown to interact with FHL3[3] and CTBP2.[3][4]


  1. ^ Sue N, Jack BH, Eaton SA, Pearson RC, Funnell AP, Turner J, Czolij R, Denyer G, Bao S, Molero-Navajas JC, Perkins A, Fujiwara Y, Orkin SH, Bell-Anderson K, Crossley M (Jun 2008). "Targeted disruption of the basic Kruppel-like factor gene (Klf3) reveals a role in adipogenesis". Mol Cell Biol 28 (12): 3967–78. doi:10.1128/MCB.01942-07. PMID 18391014.  
  2. ^ "Entrez Gene: KLF3 Kruppel-like factor 3 (basic)".  
  3. ^ a b Turner, Jeremy; Nicholas Hannah, Bishop David, Matthews Jacqueline M, Crossley Merlin (Apr. 2003). "The LIM protein FHL3 binds basic Krüppel-like factor/Krüppel-like factor 3 and its co-repressor C-terminal-binding protein 2". J. Biol. Chem. (United States) 278 (15): 12786–95. doi:10.1074/jbc.M300587200. ISSN 0021-9258. PMID 12556451.  
  4. ^ Turner, J; Crossley M (Sep. 1998). "Cloning and characterization of mCtBP2, a co-repressor that associates with basic Krüppel-like factor and other mammalian transcriptional regulators". EMBO J. (ENGLAND) 17 (17): 5129–40. doi:10.1093/emboj/17.17.5129. ISSN 0261-4189. PMID 9724649.  

Further reading

  • Turner J, Crossley M (2000). "Basic Krüppel-like factor functions within a network of interacting haematopoietic transcription factors.". Int. J. Biochem. Cell Biol. 31 (10): 1169–74. doi:10.1016/S1357-2725(99)00067-9. PMID 10582345.  
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.  
  • Turner J, Crossley M (1998). "Cloning and characterization of mCtBP2, a co-repressor that associates with basic Krüppel-like factor and other mammalian transcriptional regulators.". Embo J. 17 (17): 5129–40. doi:10.1093/emboj/17.17.5129. PMID 9724649.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Wang MJ, Qu XH, Wang LS, et al. (2003). "[cDNA cloning, subcellular localization and tissue expression of a new human Krüppel-like transcription factor: human basic Krüppel-like factor (hBKLF)]". Yi Chuan Xue Bao 30 (1): 1–9. PMID 12812068.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Perdomo J, Verger A, Turner J, Crossley M (2005). "Role for SUMO modification in facilitating transcriptional repression by BKLF.". Mol. Cell. Biol. 25 (4): 1549–59. doi:10.1128/MCB.25.4.1549-1559.2005. PMID 15684403.  
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.  
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.  

External links



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