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Kruppel-like factor 6
Symbols KLF6; BCD1; COPEB; CPBP; DKFZp686N0199; GBF; PAC1; ST12; ZF9
External IDs OMIM602053 MGI1346318 HomoloGene996 GeneCards: KLF6 Gene
RNA expression pattern
PBB GE KLF6 208961 s at tn.png
PBB GE KLF6 208960 s at tn.png
PBB GE KLF6 211610 at tn.png
More reference expression data
Species Human Mouse
Entrez 1316 23849
Ensembl ENSG00000067082 ENSMUSG00000000078
UniProt Q99612 Q3U9J1
RefSeq (mRNA) NM_001008490 NM_011803
RefSeq (protein) NP_001008490 NP_035933
Location (UCSC) Chr 10:
3.81 - 3.82 Mb
Chr 13:
5.86 - 5.87 Mb
PubMed search [1] [2]

Krueppel-like factor 6 is a protein that in humans is encoded by the KLF6 gene.[1]

It is a tumor suppressor gene.[2]

This gene encodes a nuclear protein that has three zinc fingers at the end of its C-terminal domain, a serine/threonine-rich central region, and an acidic domain lying within the N-terminal region. The zinc fingers of this protein are responsible for the specific DNA binding with the guanine-rich core promoter elements. The central region might be involved in activation or posttranslational regulatory pathways, and the acidic N-terminal domain might play an important role in the process of transcriptional activation. It is capable of activating transcription approximately 4-fold either on homologous or heterologous promoters. The DNA binding and transcriptional activity of this protein, in conjunction with its expression pattern, suggests that this protein may participate in the regulation and/or maintenance of the basal expression of pregnancy-specific glycoprotein genes and possibly other TATA box-less genes. Two transcript variants encoding the same protein have been found for this gene.[3]



KLF6 has been shown to interact with Sp1 transcription factor.[4]

See also


  1. ^ Onyango P, Koritschoner NP, Patrito LC, Zenke M, Weith A (Apr 1998). "Assignment of the gene encoding the core promoter element binding protein (COPEB) to human chromosome 10p15 by somatic hybrid analysis and fluorescence in situ hybridization". Genomics 48 (1): 143–4. doi:10.1006/geno.1997.5124. PMID 9503030.  
  2. ^ Li D, Yea S, Dolios G, et al. (October 2005). "Regulation of Kruppel-like factor 6 tumor suppressor activity by acetylation". Cancer Res. 65 (20): 9216–25. doi:10.1158/0008-5472.CAN-05-1040. PMID 16230382.  
  3. ^ "Entrez Gene: KLF6 Kruppel-like factor 6".  
  4. ^ Botella, Luisa M; Sánchez-Elsner Tilman, Sanz-Rodriguez Francisco, Kojima Soichi, Shimada Jun, Guerrero-Esteo Mercedes, Cooreman Michael P, Ratziu Vlad, Langa Carmen, Vary Calvin P H, Ramirez Jose R, Friedman Scott, Bernabéu Carmelo (Dec. 2002). "Transcriptional activation of endoglin and transforming growth factor-beta signaling components by cooperative interaction between Sp1 and KLF6: their potential role in the response to vascular injury". Blood (United States) 100 (12): 4001–10. doi:10.1182/blood.V100.12.4001. ISSN 0006-4971. PMID 12433697.  

Further reading

  • Narla G, Friedman SL, Martignetti JA (2003). "Krüppel cripples prostate cancer: KLF6 progress and prospects.". Am. J. Pathol. 162 (4): 1047–52. PMID 12651597.  
  • El Rouby S, Newcomb EW (1997). "Identification of Bcd, a novel proto-oncogene expressed in B-cells.". Oncogene 13 (12): 2623–30. PMID 9000136.  
  • Koritschoner NP, Bocco JL, Panzetta-Dutari GM, et al. (1997). "A novel human zinc finger protein that interacts with the core promoter element of a TATA box-less gene.". J. Biol. Chem. 272 (14): 9573–80. doi:10.1074/jbc.272.14.9573. PMID 9083102.  
  • Suzuki T, Yamamoto T, Kurabayashi M, et al. (1998). "Isolation and initial characterization of GBF, a novel DNA-binding zinc finger protein that binds to the GC-rich binding sites of the HIV-1 promoter.". J. Biochem. 124 (2): 389–95. PMID 9685731.  
  • Ratziu V, Lalazar A, Wong L, et al. (1998). "Zf9, a Kruppel-like transcription factor up-regulated in vivo during early hepatic fibrosis.". Proc. Natl. Acad. Sci. U.S.A. 95 (16): 9500–5. doi:10.1073/pnas.95.16.9500. PMID 9689109.  
  • Okano J, Opitz OG, Nakagawa H, et al. (2000). "The Krüppel-like transcriptional factors Zf9 and GKLF coactivate the human keratin 4 promoter and physically interact.". FEBS Lett. 473 (1): 95–100. doi:10.1016/S0014-5793(00)01468-X. PMID 10802067.  
  • Narla G, Heath KE, Reeves HL, et al. (2002). "KLF6, a candidate tumor suppressor gene mutated in prostate cancer.". Science 294 (5551): 2563–6. doi:10.1126/science.1066326. PMID 11752579.  
  • Botella LM, Sánchez-Elsner T, Sanz-Rodriguez F, et al. (2003). "Transcriptional activation of endoglin and transforming growth factor-beta signaling components by cooperative interaction between Sp1 and KLF6: their potential role in the response to vascular injury.". Blood 100 (12): 4001–10. doi:10.1182/blood.V100.12.4001. PMID 12433697.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Chen HK, Liu XQ, Lin J, et al. (2003). "[Mutation analysis of KLF6 gene in human nasopharyngeal carcinomas]". Ai Zheng 21 (10): 1047–50. PMID 12508640.  
  • Warke VG, Nambiar MP, Krishnan S, et al. (2003). "Transcriptional activation of the human inducible nitric-oxide synthase promoter by Kruppel-like factor 6.". J. Biol. Chem. 278 (17): 14812–9. doi:10.1074/jbc.M300787200. PMID 12590140.  
  • Chen C, Hyytinen ER, Sun X, et al. (2003). "Deletion, mutation, and loss of expression of KLF6 in human prostate cancer.". Am. J. Pathol. 162 (4): 1349–54. PMID 12651626.  
  • Jeng YM, Hsu HC (2003). "KLF6, a putative tumor suppressor gene, is mutated in astrocytic gliomas.". Int. J. Cancer 105 (5): 625–9. doi:10.1002/ijc.11123. PMID 12740910.  
  • Bayat A, Watson JS, Stanley JK, et al. (2003). "Genetic susceptibility to dupuytren disease: association of Zf9 transcription factor gene.". Plast. Reconstr. Surg. 111 (7): 2133–9. doi:10.1097/01.PRS.0000060531.98180.32. PMID 12794452.  
  • Reeves HL, Narla G, Ogunbiyi O, et al. (2004). "Kruppel-like factor 6 (KLF6) is a tumor-suppressor gene frequently inactivated in colorectal cancer.". Gastroenterology 126 (4): 1090–103. doi:10.1053/j.gastro.2004.01.005. PMID 15057748.  
  • Kimmelman AC, Qiao RF, Narla G, et al. (2004). "Suppression of glioblastoma tumorigenicity by the Kruppel-like transcription factor KLF6.". Oncogene 23 (29): 5077–83. doi:10.1038/sj.onc.1207662. PMID 15064720.  
  • Glinsky GV, Glinskii AB, Stephenson AJ, et al. (2004). "Gene expression profiling predicts clinical outcome of prostate cancer.". J. Clin. Invest. 113 (6): 913–23. doi:10.1172/JCI200420032. PMID 15067324.  
  • Rubinstein M, Idelman G, Plymate SR, et al. (2004). "Transcriptional activation of the insulin-like growth factor I receptor gene by the Kruppel-like factor 6 (KLF6) tumor suppressor protein: potential interactions between KLF6 and p53.". Endocrinology 145 (8): 3769–77. doi:10.1210/en.2004-0173. PMID 15131018.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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