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KLF8: Wikis


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From Wikipedia, the free encyclopedia

Kruppel-like factor 8
Symbols KLF8; BKLF3; DKFZp686O08126; DXS741; MGC138314; ZNF741
External IDs OMIM300286 MGI2442430 HomoloGene68549 GeneCards: KLF8 Gene
RNA expression pattern
PBB GE KLF8 219930 at tn.png
More reference expression data
Species Human Mouse
Entrez 11279 245671
Ensembl ENSG00000102349 ENSMUSG00000041649
UniProt O95600 n/a
RefSeq (mRNA) NM_007250 NM_173780
RefSeq (protein) NP_009181 NP_776141
Location (UCSC) Chr X:
56.28 - 56.33 Mb
Chr X:
148.7 - 148.74 Mb
PubMed search [1] [2]

Krueppel-like factor 8 is a protein that in humans is encoded by the KLF8 gene.[1]



KLF8 has been shown to interact with CTBP2.[2]


  1. ^ "Entrez Gene: KLF8 Kruppel-like factor 8".  
  2. ^ van Vliet, J; Turner J, Crossley M (May. 2000). "Human Krüppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription". Nucleic Acids Res. (ENGLAND) 28 (9): 1955–62. PMID 10756197.  

Further reading

  • van Vliet J, Turner J, Crossley M (2000). "Human Krüppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription.". Nucleic Acids Res. 28 (9): 1955–62. doi:10.1093/nar/28.9.1955. PMID 10756197.  
  • Lossi AM, Laugier-Anfossi F, Depetris D, et al. (2002). "Abnormal expression of the KLF8 (ZNF741) gene in a female patient with an X;autosome translocation t(X;21)(p11.2;q22.3) and non-syndromic mental retardation.". J. Med. Genet. 39 (2): 113–7. doi:10.1136/jmg.39.2.113. PMID 11836360.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Turner J, Nicholas H, Bishop D, et al. (2003). "The LIM protein FHL3 binds basic Krüppel-like factor/Krüppel-like factor 3 and its co-repressor C-terminal-binding protein 2.". J. Biol. Chem. 278 (15): 12786–95. doi:10.1074/jbc.M300587200. PMID 12556451.  
  • Zhao J, Bian ZC, Yee K, et al. (2003). "Identification of transcription factor KLF8 as a downstream target of focal adhesion kinase in its regulation of cyclin D1 and cell cycle progression.". Mol. Cell 11 (6): 1503–15. doi:10.1016/S1097-2765(03)00179-5. PMID 12820964.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMID 15772651.  
  • Zhang P, Basu P, Redmond LC, et al. (2006). "A functional screen for Krüppel-like factors that regulate the human gamma-globin gene through the CACCC promoter element.". Blood Cells Mol. Dis. 35 (2): 227–35. doi:10.1016/j.bcmd.2005.04.009. PMID 16023392.  
  • Wang X, Zhao J (2007). "KLF8 transcription factor participates in oncogenic transformation.". Oncogene 26 (3): 456–61. doi:10.1038/sj.onc.1209796. PMID 16832343.  
  • Hu JH, Navas P, Cao H, et al. (2007). "Systematic RNAi studies on the role of Sp/KLF factors in globin gene expression and erythroid differentiation.". J. Mol. Biol. 366 (4): 1064–73. doi:10.1016/j.jmb.2006.12.047. PMID 17224162.  
  • Wang X, Zheng M, Liu G, et al. (2007). "Krüppel-like factor 8 induces epithelial to mesenchymal transition and epithelial cell invasion.". Cancer Res. 67 (15): 7184–93. doi:10.1158/0008-5472.CAN-06-4729. PMID 17671186.  

External links



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