The Full Wiki

KLF9: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

edit
Kruppel-like factor 9
Identifiers
Symbols KLF9; BTEB; BTEB1
External IDs OMIM602902 MGI1333856 HomoloGene931 GeneCards: KLF9 Gene
RNA expression pattern
PBB GE KLF9 203543 s at tn.png
PBB GE KLF9 203541 s at tn.png
PBB GE KLF9 203542 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 687 16601
Ensembl ENSG00000119138 ENSMUSG00000033863
UniProt Q13886 Q8CEC4
RefSeq (mRNA) NM_001206 XM_988516
RefSeq (protein) NP_001197 XP_993610
Location (UCSC) Chr 9:
72.19 - 72.22 Mb
Chr 19:
23.21 - 23.23 Mb
PubMed search [1] [2]

Krueppel-like factor 9 is a protein that in humans is encoded by the KLF9 gene.[1][2]

The protein encoded by this gene is a transcription factor that binds to GC box elements located in the promoter. Binding of the encoded protein to a single GC box inhibits mRNA expression while binding to tandemly repeated GC box elements activates transcription.[2]

Contents

Interactions

KLF9 has been shown to interact with Progesterone receptor.[3]

References

  1. ^ Imataka H, Sogawa K, Yasumoto K, Kikuchi Y, Sasano K, Kobayashi A, Hayami M, Fujii-Kuriyama Y (Nov 1992). "Two regulatory proteins that bind to the basic transcription element (BTE), a GC box sequence in the promoter region of the rat P-4501A1 gene". EMBO J 11 (10): 3663–71. PMID 1356762.  
  2. ^ a b "Entrez Gene: KLF9 Kruppel-like factor 9". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=687.  
  3. ^ Zhang, Xue-Lian; Zhang Daying, Michel Frank J, Blum Jason L, Simmen Frank A, Simmen Rosalia C M (Jun. 2003). "Selective interactions of Kruppel-like factor 9/basic transcription element-binding protein with progesterone receptor isoforms A and B determine transcriptional activity of progesterone-responsive genes in endometrial epithelial cells". J. Biol. Chem. (United States) 278 (24): 21474–82. doi:10.1074/jbc.M212098200. ISSN 0021-9258. PMID 12672823.  

Further reading

  • Kobayashi A, Sogawa K, Imataka H, Fujii-Kuriyama Y (1995). "Analysis of functional domains of a GC box-binding protein, BTEB.". J. Biochem. 117 (1): 91–5. PMID 7775404.  
  • Imataka H, Nakayama K, Yasumoto K, et al. (1994). "Cell-specific translational control of transcription factor BTEB expression. The role of an upstream AUG in the 5'-untranslated region.". J. Biol. Chem. 269 (32): 20668–73. PMID 8051167.  
  • Imataka H, Mizuno A, Fujii-Kuriyama Y, Hayami M (1994). "Activation of the human immunodeficiency virus type 1 long terminal repeat by BTEB, a GC box-binding transcription factor.". AIDS Res. Hum. Retroviruses 9 (9): 825–31. doi:10.1089/aid.1993.9.825. PMID 8257632.  
  • Hashimoto H, Toide K, Kitamura R, et al. (1994). "Gene structure of CYP3A4, an adult-specific form of cytochrome P450 in human livers, and its transcriptional control.". Eur. J. Biochem. 218 (2): 585–95. doi:10.1111/j.1432-1033.1993.tb18412.x. PMID 8269949.  
  • Ohe N, Yamasaki Y, Sogawa K, et al. (1994). "Chromosomal localization and cDNA sequence of human BTEB, a GC box binding protein.". Somat. Cell Mol. Genet. 19 (5): 499–503. doi:10.1007/BF01233255. PMID 8291025.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Zhang XL, Zhang D, Michel FJ, et al. (2003). "Selective interactions of Kruppel-like factor 9/basic transcription element-binding protein with progesterone receptor isoforms A and B determine transcriptional activity of progesterone-responsive genes in endometrial epithelial cells.". J. Biol. Chem. 278 (24): 21474–82. doi:10.1074/jbc.M212098200. PMID 12672823.  
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMID 15164053.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Velarde MC, Iruthayanathan M, Eason RR, et al. (2006). "Progesterone receptor transactivation of the secretory leukocyte protease inhibitor gene in Ishikawa endometrial epithelial cells involves recruitment of Krüppel-like factor 9/basic transcription element binding protein-1.". Endocrinology 147 (4): 1969–78. doi:10.1210/en.2005-1419. PMID 16384861.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message