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From Wikipedia, the free encyclopedia

Kallikrein-related peptidase 11
Symbols KLK11; MGC33060; PRSS20; TLSP
External IDs OMIM604434 MGI1929977 HomoloGene27048 GeneCards: KLK11 Gene
RNA expression pattern
PBB GE KLK11 205470 s at tn.png
More reference expression data
Species Human Mouse
Entrez 11012 56538
Ensembl ENSG00000167757 ENSMUSG00000067616
UniProt Q9UBX7 Q14BZ7
RefSeq (mRNA) NM_006853 NM_019974
RefSeq (protein) NP_006844 NP_064358
Location (UCSC) Chr 19:
56.22 - 56.22 Mb
Chr 7:
43.64 - 43.65 Mb
PubMed search [1] [2]

Kallikrein-11 is a protein that in humans is encoded by the KLK11 gene.[1][2][3][4][5]

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in two transcript variants encoding two different isoforms which are differentially expressed.[5]


  1. ^ Yoshida S, Taniguchi M, Suemoto T, Oka T, He X, Shiosaka S (Oct 1998). "cDNA cloning and expression of a novel serine protease, TLSP". Biochim Biophys Acta 1399 (2-3): 225-8. PMID 9765601.  
  2. ^ Yousef GM, Scorilas A, Diamandis EP (Apr 2000). "Genomic organization, mapping, tissue expression, and hormonal regulation of trypsin-like serine protease (TLSP PRSS20), a new member of the human kallikrein gene family". Genomics 63 (1): 88-96. doi:10.1006/geno.1999.6072. PMID 10662548.  
  3. ^ Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biol Chem 387 (6): 637-41. doi:10.1515/BC.2006.082. PMID 16800724.  
  4. ^ "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biol Chem 387 (6): 635-824. Jun 2006. doi:10.1515/BC.2006.081. PMID 16800723.  
  5. ^ a b "Entrez Gene: KLK11 kallikrein-related peptidase 11".  

Further reading

  • Mitsui S, Yamada T, Okui A, et al. (2000). "A novel isoform of a kallikrein-like protease, TLSP/hippostasin, (PRSS20), is expressed in the human brain and prostate.". Biochem. Biophys. Res. Commun. 272 (1): 205–11. doi:10.1006/bbrc.2000.2761. PMID 10872828.  
  • Gan L, Lee I, Smith R, et al. (2001). "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region.". Gene 257 (1): 119–30. doi:10.1016/S0378-1119(00)00382-6. PMID 11054574.  
  • Nakamura T, Mitsui S, Okui A, et al. (2002). "Alternative splicing isoforms of hippostasin (PRSS20/KLK11) in prostate cancer cell lines.". Prostate 49 (1): 72–8. doi:10.1002/pros.1119. PMID 11550212.  
  • Diamandis EP, Okui A, Mitsui S, et al. (2002). "Human kallikrein 11: a new biomarker of prostate and ovarian carcinoma.". Cancer Res. 62 (1): 295–300. PMID 11782391.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Nakamura T, Mitsui S, Okui A, et al. (2003). "Molecular cloning and expression of a variant form of hippostasin/KLK11 in prostate.". Prostate 54 (4): 299–305. doi:10.1002/pros.10191. PMID 12539228.  
  • Nakamura T, Stephan C, Scorilas A, et al. (2003). "Quantitative analysis of hippostasin/KLK11 gene expression in cancerous and noncancerous prostatic tissues.". Urology 61 (5): 1042–6. doi:10.1016/S0090-4295(02)02443-3. PMID 12736044.  
  • Borgoño CA, Fracchioli S, Yousef GM, et al. (2003). "Favorable prognostic value of tissue human kallikrein 11 (hK11) in patients with ovarian carcinoma.". Int. J. Cancer 106 (4): 605–10. doi:10.1002/ijc.11296. PMID 12845660.  
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.  
  • Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.  
  • Shigemasa K, Gu L, Tanimoto H, et al. (2004). "Human kallikrein gene 11 (KLK11) mRNA overexpression is associated with poor prognosis in patients with epithelial ovarian cancer.". Clin. Cancer Res. 10 (8): 2766–70. doi:10.1158/1078-0432.CCR-03-0269. PMID 15102682.  
  • Diamandis EP, Borgoño CA, Scorilas A, et al. (2005). "Human kallikrein 11: an indicator of favorable prognosis in ovarian cancer patients.". Clin. Biochem. 37 (9): 823–9. doi:10.1016/j.clinbiochem.2004.04.009. PMID 15329323.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Stavropoulou P, Gregorakis AK, Plebani M, Scorilas A (2005). "Expression analysis and prognostic significance of human kallikrein 11 in prostate cancer.". Clin. Chim. Acta 357 (2): 190–5. doi:10.1016/j.cccn.2005.03.026. PMID 15893744.  
  • Planque C, Aïnciburu M, Heuzé-Vourc'h N, et al. (2006). "Expression of the human kallikrein genes 10 (KLK10) and 11 (KLK11) in cancerous and non-cancerous lung tissues.". Biol. Chem. 387 (6): 783–8. doi:10.1515/BC.2006.098. PMID 16800740.  
  • Mitsui S, Nakamura T, Okui A, et al. (2006). "Multiple promoters regulate tissue-specific alternative splicing of the human kallikrein gene, KLK11/hippostasin.". FEBS J. 273 (16): 3678–86. doi:10.1111/j.1742-4658.2006.05372.x. PMID 16911518.  


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