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Killer cell lectin-like receptor subfamily B, member 1
Symbols KLRB1; CD161; CLEC5B; MGC138614; NKR; NKR-P1; NKR-P1A; NKRP1A; hNKR-P1A
External IDs OMIM602890 MGI107539 HomoloGene84369 GeneCards: KLRB1 Gene
RNA expression pattern
PBB GE KLRB1 214470 at tn.png
More reference expression data
Species Human Mouse
Entrez 3820 17058
Ensembl ENSG00000111796 n/a
UniProt Q12918 n/a
RefSeq (mRNA) NM_002258 NM_008526
RefSeq (protein) NP_002249 NP_032552
Location (UCSC) Chr 12:
9.64 - 9.65 Mb
PubMed search [1] [2]

Killer cell lectin-like receptor subfamily B, member 1, also known as KLRB1, NKR-P1A or CD161 (cluster of differentiation 161), is a human gene.[1]

Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein, NKR-P1A or CD161, is classified as a type II membrane protein because it has an external C terminus.[1] NKR-P1A, the receptor encoded by the KLRB1 gene, recognizes Lectin Like Transcript-1 (LLT1) as a functional ligand.


Further reading

  • Smith FB, Connor JM, Lee AJ, et al. (2004). "Relationship of the platelet glycoprotein PlA and fibrinogen T/G+1689 polymorphisms with peripheral arterial disease and ischaemic heart disease.". Thromb. Res. 112 (4): 209–16. doi:10.1016/j.thromres.2003.11.010. PMID 14987913.  
  • Lanier LL, Chang C, Phillips JH (1994). "Human NKR-P1A. A disulfide-linked homodimer of the C-type lectin superfamily expressed by a subset of NK and T lymphocytes.". J. Immunol. 153 (6): 2417–28. PMID 8077657.  
  • Poggi A, Costa P, Morelli L, et al. (1996). "Expression of human NKRP1A by CD34+ immature thymocytes: NKRP1A-mediated regulation of proliferation and cytolytic activity.". Eur. J. Immunol. 26 (6): 1266–72. PMID 8647203.  
  • Renedo M, Arce I, Rodríguez A, et al. (1997). "The human natural killer gene complex is located on chromosome 12p12-p13.". Immunogenetics 46 (4): 307–11. PMID 9218532.  
  • Poggi A, Costa P, Zocchi MR, Moretta L (1997). "Phenotypic and functional analysis of CD4+ NKRP1A+ human T lymphocytes. Direct evidence that the NKRP1A molecule is involved in transendothelial migration.". Eur. J. Immunol. 27 (9): 2345–50. PMID 9341779.  
  • Poggi A, Rubartelli A, Moretta L, Zocchi MR (1998). "Expression and function of NKRP1A molecule on human monocytes and dendritic cells.". Eur. J. Immunol. 27 (11): 2965–70. PMID 9394825.  
  • Poggi A, Costa P, Tomasello E, Moretta L (1998). "IL-12-induced up-regulation of NKRP1A expression in human NK cells and consequent NKRP1A-mediated down-regulation of NK cell activation.". Eur. J. Immunol. 28 (5): 1611–6. PMID 9603467.  
  • Carlyle JR, Martin A, Mehra A, et al. (1999). "Mouse NKR-P1B, a novel NK1.1 antigen with inhibitory function.". J. Immunol. 162 (10): 5917–23. PMID 10229828.  
  • Ishihara S, Nieda M, Kitayama J, et al. (1999). "CD8(+)NKR-P1A (+)T cells preferentially accumulate in human liver.". Eur. J. Immunol. 29 (8): 2406–13. PMID 10458753.  
  • Iiai T, Watanabe H, Suda T, et al. (2002). "CD161+ T (NT) cells exist predominantly in human intestinal epithelium as well as in liver.". Clin. Exp. Immunol. 129 (1): 92–8. PMID 12100027.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Iizuka K, Naidenko OV, Plougastel BF, et al. (2003). "Genetically linked C-type lectin-related ligands for the NKRP1 family of natural killer cell receptors.". Nat. Immunol. 4 (8): 801–7. doi:10.1038/ni954. PMID 12858173.  
  • Carlyle JR, Jamieson AM, Gasser S, et al. (2004). "Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors.". Proc. Natl. Acad. Sci. U.S.A. 101 (10): 3527–32. doi:10.1073/pnas.0308304101. PMID 14990792.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Aldemir H, Prod'homme V, Dumaurier MJ, et al. (2006). "Cutting edge: lectin-like transcript 1 is a ligand for the CD161 receptor.". J. Immunol. 175 (12): 7791–5. PMID 16339512.  
  • Rosen DB, Bettadapura J, Alsharifi M, et al. (2006). "Cutting edge: lectin-like transcript-1 is a ligand for the inhibitory human NKR-P1A receptor.". J. Immunol. 175 (12): 7796–9. PMID 16339513.  
  • Pozo D, Valés-Gómez M, Mavaddat N, et al. (2006). "CD161 (human NKR-P1A) signaling in NK cells involves the activation of acid sphingomyelinase.". J. Immunol. 176 (4): 2397–406. PMID 16455998.  
  • Christiansen D, Mouhtouris E, Milland J, et al. (2007). "Recognition of a carbohydrate xenoepitope by human NKRP1A (CD161).". Xenotransplantation 13 (5): 440–6. doi:10.1111/j.1399-3089.2006.00332.x. PMID 16925668.  
  • Rosen, DB, Cao W, et al. (2008). "Functional Consequences of Interactions between Human NKR-P1A and Its Ligand LLT1 Expressed on Activated Dendritic Cells and B Cells.". J. Immunol. 180 (10): 6508–6517. PMID 18453569.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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