The Full Wiki

More info on KLRK1

KLRK1: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

edit
Killer cell lectin-like receptor subfamily K, member 1

PDB rendering based on 1hyr.
Available structures
1hyr, 1kcg, 1mpu
Identifiers
Symbols KLRK1; CD314; D12S2489E; KLR; NKG2-D; NKG2D
External IDs MGI1196250 HomoloGene7209 GeneCards: KLRK1 Gene
Orthologs
Species Human Mouse
Entrez 22914 27007
Ensembl n/a ENSMUSG00000030149
UniProt n/a Q2TJJ6
RefSeq (mRNA) NM_007360 XM_001004553
RefSeq (protein) NP_031386 XP_001004553
Location (UCSC) n/a Chr 6:
129.58 - 129.59 Mb
PubMed search [1] [2]

NKG2-D type II integral membrane protein is a protein that in humans is encoded by the KLRK1 gene.[1][2] KLRK1 has also been designated as CD314 (cluster of differentiation 314).

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. D12S2489E is a member of the NKG2 group which are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. The first non-coding exon at the 5' end of the D12S2489E transcript is included in the 3' end of the KLRC4 transcript.[3]

References

  1. ^ Glienke J, Sobanov Y, Brostjan C, Steffens C, Nguyen C, Lehrach H, Hofer E, Francis F (Sep 1998). "The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex". Immunogenetics 48 (3): 163-73. PMID 9683661.  
  2. ^ Houchins JP, Yabe T, McSherry C, Bach FH (Apr 1991). "DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells". J Exp Med 173 (4): 1017-20. PMID 2007850.  
  3. ^ "Entrez Gene: KLRK1 killer cell lectin-like receptor subfamily K, member 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22914.  

Further reading

  • Raulet DH (2003). "Roles of the NKG2D immunoreceptor and its ligands.". Nat. Rev. Immunol. 3 (10): 781–90. doi:10.1038/nri1199. PMID 14523385.  
  • Lanier LL (2004). "NKG2D.". J. Biol. Regul. Homeost. Agents 17 (4): 338–40. PMID 15065764.  
  • Coudert JD, Held W (2006). "The role of the NKG2D receptor for tumor immunity.". Semin. Cancer Biol. 16 (5): 333–43. doi:10.1016/j.semcancer.2006.07.008. PMID 16914326.  
  • Spertini O, Frei PC (1986). "Biophysical properties and morphology of purified antigen associated with non-A, non-B hepatitis.". Med. Microbiol. Immunol. 175 (4): 229–39. doi:10.1007/BF02123731. PMID 2426565.  
  • Plougastel B, Trowsdale J (1998). "Cloning of NKG2-F, a new member of the NKG2 family of human natural killer cell receptor genes.". Eur. J. Immunol. 27 (11): 2835–9. doi:10.1002/eji.1830271114. PMID 9394807.  
  • Plougastel B, Trowsdale J (1998). "Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes.". Genomics 49 (2): 193–9. doi:10.1006/geno.1997.5197. PMID 9598306.  
  • Li P, Willie ST, Bauer S, et al. (1999). "Crystal structure of the MHC class I homolog MIC-A, a gammadelta T cell ligand.". Immunity 10 (5): 577–84. doi:10.1016/S1074-7613(00)80057-6. PMID 10367903.  
  • Bauer S, Groh V, Wu J, et al. (1999). "Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA.". Science 285 (5428): 727–9. doi:10.1126/science.285.5428.727. PMID 10426993.  
  • Wu J, Song Y, Bakker AB, et al. (1999). "An activating immunoreceptor complex formed by NKG2D and DAP10.". Science 285 (5428): 730–2. doi:10.1126/science.285.5428.730. PMID 10426994.  
  • Cosman D, Müllberg J, Sutherland CL, et al. (2001). "ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor.". Immunity 14 (2): 123–33. doi:10.1016/S1074-7613(01)00095-4. PMID 11239445.  
  • Diefenbach A, Jamieson AM, Liu SD, et al. (2001). "Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages.". Nat. Immunol. 1 (2): 119–26. doi:10.1038/77793. PMID 11248803.  
  • Li P, Morris DL, Willcox BE, et al. (2001). "Complex structure of the activating immunoreceptor NKG2D and its MHC class I-like ligand MICA.". Nat. Immunol. 2 (5): 443–51. doi:10.1038/87757. PMID 11323699.  
  • Shum BP, Flodin LR, Muir DG, et al. (2002). "Conservation and variation in human and common chimpanzee CD94 and NKG2 genes.". J. Immunol. 168 (1): 240–52. PMID 11751968.  
  • Radaev S, Rostro B, Brooks AG, et al. (2002). "Conformational plasticity revealed by the cocrystal structure of NKG2D and its class I MHC-like ligand ULBP3.". Immunity 15 (6): 1039–49. doi:10.1016/S1074-7613(01)00241-2. PMID 11754823.  
  • Sutherland CL, Chalupny NJ, Schooley K, et al. (2002). "UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells.". J. Immunol. 168 (2): 671–9. PMID 11777960.  
  • Holmes MA, Li P, Petersdorf EW, Strong RK (2002). "Structural studies of allelic diversity of the MHC class I homolog MIC-B, a stress-inducible ligand for the activating immunoreceptor NKG2D.". J. Immunol. 169 (3): 1395–400. PMID 12133964.  
  • Groh V, Wu J, Yee C, Spies T (2002). "Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation.". Nature 419 (6908): 734–8. doi:10.1038/nature01112. PMID 12384702.  
  • Gilfillan S, Ho EL, Cella M, et al. (2002). "NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation.". Nat. Immunol. 3 (12): 1150–5. doi:10.1038/ni857. PMID 12426564.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message