The Full Wiki

Ketazolam: Wikis

  

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

Ketazolam
Systematic (IUPAC) name
11-chloro- 8,12b-dihydro- 2,8-dimethyl- 12b-phenyl- 4H-[1,3]oxazino[3,2-d] [1,4]benzodiazepine- 4,7(6H)- dione[1]
Identifiers
CAS number 27223-35-4
ATC code N05BA10
PubChem 33746
DrugBank ?
Chemical data
Formula C 20H17ClN2O3  
Mol. mass 368.8
Pharmacokinetic data
Bioavailability  ?
Metabolism Hepatic
Half life 26-200 hours
Excretion Renal
Therapeutic considerations
Pregnancy cat.  ?
Legal status Schedule IV(US)
Routes Oral
 Yes check.svgY(what is this?)  (verify)

Ketazolam (marketed under the brand names Anseren, Ansieten, Ansietil, Marcen, Sedatival, Sedotime, Solatran and Unakalm) is a drug which is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties.

Contents

Therapeutic uses

It is used for the treatment of anxiety and has similar effectiveness compared to diazepam. Ketazolam also appears to produce a reduced level of side effects such as sedation compared with diazepam and the side effects when they occur tend to be milder.[2][3][4][5] Ketazolam is also an effective antispasmodic drug and is used for the treatment of spasticity.[6][7][8]

Availability

Ketazolam is not approved for sale in Australia, Canada, United Kingdom or the United States.[9] In South Africa, GlaxoSmithKline markets ketazolam under its Solatran brand name.[10]

Tolerance and physical dependence

Chronic use of ketazolam as with other benzodiazepines can lead to physical dependence and the appearance of the benzodiazepine withdrawal syndrome upon cessation of use or decrease in dose. Tolerance to ketazolam's therapeutic effects occurs over a period of 15 days.[11]

Contraindications and special caution

Benzodiazepines require special precaution if used in the elderly, during pregnancy, in children, alcohol or drug-dependent individuals and individuals with comorbid psychiatric disorders.[12]

Pharmacokinetics

Ketazolam breaks down in the blood to diazepam which breaks down to demoxepam which breaks down to desmethyldiazepam.[13]

Warnings

The U.S. Food and Drug Administration warns that in Spain, ketazolam marketed as Marcen may sometimes be mistakenly confused with Narcan.[14]

Legal status

Ketazolam is a List II drugs of the Opium Law in the Netherlands. Ketazolam is a Schedule IV drug under the drugs misuse act in the US.[15]

See also

References

  1. ^ Vega D; Fernández D, Echeverría G (July 2001). "Ketazolam". Acta Crystallogr C 57 (Pt 7): 848–50. doi:10.1107/S0108270101006175. PMID 11443263.  
  2. ^ Anhalt HS; Young R, Roginsky M (November 1980). Double-blind comparison of ketazolam, diazepam and placebo in once-a-day vs t.i.d. dosing. 41. pp. 386–92. PMID 6108319.  
  3. ^ Kim KK; Sirman A, Trainor FS, Lee BY (1980). "Anxiolytic efficacy and safety of ketazolam compared with diazepam and placebo". Clin Ther 3 (1): 9–14. PMID 6105920.  
  4. ^ Fabre LF Jr; Harris RT (1976). "Double-blind placebo-controlled efficacy study of ketazolam (U-28,774)". J Int Med Res 4 (1): 50–4. PMID 16791.  
  5. ^ Rickels K; Csanalosi I, Greisman P, Mirman MJ, Morris RJ, Weise CC, Weiss G (October 1980). "Ketazolam and diazepam in anxiety: a controlled study". J Clin Pharmacol 20 (10): 581–9. PMID 6108335.  
  6. ^ Basmajian JV; Shankardass K, Russell D (August 1986). "Ketazolam once daily for spasticity: double-blind cross-over study". Arch Phys Med Rehabil 67 (8): 556–7. PMID 2874780.  
  7. ^ Katz RT (June 1988). "Management of spasticity". Am J Phys Med Rehabil 67 (3): 108–16. doi:10.1097/00002060-198806000-00004. PMID 3288246.  
  8. ^ Basmajian JV; Shankardass K, Russell D, Yucel V (November 1984). "Ketazolam treatment for spasticity: double-blind study of a new drug". Arch Phys Med Rehabil 65 (11): 698–701. PMID 6149738.  
  9. ^ "Benzodiazepine Names". The Tranquilliser Recovery and Awareness Place. http://www.non-benzodiazepines.org.uk/benzodiazepine-names.html#Ketazolam. Retrieved 26 August 2008.  
  10. ^ "SOLATRAN 15 (capsules) - SOLATRAN 30 (capsules)". South African Electronic Package Inserts. 12. http://home.intekom.com/pharm/smith_kb/solatran.html. Retrieved 26 August 2008.  
  11. ^ Higgitt A; Fonagy P, Lader M (1988). "The natural history of tolerance to the benzodiazepines". Psychol Med Monogr Suppl 13: 1–55. PMID 2908516.  
  12. ^ Authier, N.; Balayssac, D.; Sautereau, M.; Zangarelli, A.; Courty, P.; Somogyi, AA.; Vennat, B.; Llorca, PM. et al. (Nov 2009). "Benzodiazepine dependence: focus on withdrawal syndrome.". Ann Pharm Fr 67 (6): 408-13. doi:10.1016/j.pharma.2009.07.001. PMID 19900604.  
  13. ^ Joyce JR, Bal TS, Ardrey RE, Stevens HM, Moffat AC (June 1984). "The decomposition of benzodiazepines during analysis by capillary gas chromatography/mass spectrometry". Biomed Mass Spectrom. 11 (6): 284. doi:10.1002/bms.1200110607. PMID 6743768.  
  14. ^ Food and Drug Administration (January 2006). "FDA Public Health Advisory - Consumers Filling U.S. Prescriptions Abroad May Get the Wrong Active Ingredient Because of Confusing Drug Names". FDA (USA). http://www.fda.gov/oc/opacom/reports/confusingnames.html. Retrieved 26 August 2006.  
  15. ^ Drug Enforcement Administration (USA). "Drug Scheduling". United States Government. http://www.dea.gov/pubs/scheduling.html. Retrieved 26 August 2008.  







Got something to say? Make a comment.
Your name
Your email address
Message