The Full Wiki

More info on Killer-cell immunoglobulin-like receptor

Killer-cell immunoglobulin-like receptor: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

Killer-cell immunoglobulin-like receptors (KIRs), are a family of cell surface proteins found on important cells of the immune system called natural killer (NK) cells. They regulate the killing function of these cells by interacting with MHC class I molecules, which are expressed on all cell types. This interaction allows them to detect virally infected cells or tumor cells that have a characteristic low level of Class I MHC on their surface. Most KIRs are inhibitory, meaning that their recognition of MHC suppresses the cytotoxic activity of their NK cell. Only a limited number of KIRs have the ability to activate cells.[1] KIR molecules are highly polymorphic, meaning their gene sequences differ greatly between individuals, so that different individuals possess different arrays/repertoires of KIR genes.[2]

Genes

  • two domains, long cytoplasmic tail: KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DL5B,
  • two domains, short cytoplasmic tail: KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5
  • three domains, long cytoplasmic tail: KIR3DL1, KIR3DL2, KIR3DL3
  • three domains, short cytoplasmic tail: KIR3DS1

References

  1. ^ Vilches C, Parham P (2002). "KIR: diverse, rapidly evolving receptors of innate and adaptive immunity". Annu Rev Immunol 20: 217–51. doi:10.1146/annurev.immunol.20.092501.134942. PMID 11861603.  
  2. ^ Uhrberg M (2005). "The KIR gene family: life in the fast lane of evolution". Eur J Immunol 35 (1): 10–5. doi:10.1002/eji.200425743. PMID 15580655.  

External links

Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message