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L-selectin: Wikis

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Selectin L (lymphocyte adhesion molecule 1)
Identifiers
Symbols SELL; CD62L; LAM-1; LAM1; LECAM1; LNHR; LSEL; LYAM1; Leu-8; Lyam-1; PLNHR; TQ1; hLHRc; MEL14; MEL-14
External IDs OMIM153240 MGI98279 HomoloGene539 GeneCards: SELL Gene
RNA expression pattern
PBB GE SELL 204563 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6402 20343
Ensembl ENSG00000188404 ENSMUSG00000026581
UniProt P14151 Q3TA36
RefSeq (mRNA) NM_000655 NM_011346
RefSeq (protein) NP_000646 NP_035476
Location (UCSC) Chr 1:
167.93 - 167.95 Mb
Chr 1:
165.9 - 165.91 Mb
PubMed search [1] [2]

L-selectin, also known as CD62L, is a cell adhesion molecule found on leukocytes. It belongs to the selectin family of proteins, which recognise sialylated carbohydrate groups. It is cleaved by ADAM17.

SELL is a cell surface component that is a member of a family of adhesion/homing receptors which play important roles in leukocyte-endothelial cell interactions. The molecule is composed of multiple domains: one homologous to lectins, one to epidermal growth factor, and two to the consensus repeat units found in C3/C4 binding proteins.[1]

Contents

Ligands

Function

L-selectin acts as a "homing receptor" for leukocytes to enter secondary lymphoid tissues via high endothelial venules. Ligands present on endothelial cells will bind to leukocyte expressing L-selectin, slowing leukocyte trafficking through the blood, and facilitating entry into a secondary lymphoid organ at that point[2]. The receptor is commonly found on the cell surfaces of T cells. Naive T-lymphocytes, which have not yet encountered their specific antigen, need to enter secondary lymph nodes to encounter their antigen. Central memory T-lymphocytes, which have encountered antigen, express L-selectin to localize in secondary lymphoid organs. Here they reside ready to proliferate upon re-encountering antigen. Effector memory T-lymphocytes do not express L-selectin. These cells circulate in the periphery, so they do not express L-selectin, and have immediate effector functions upon encountering antigen.

References

  1. ^ "Entrez Gene: SELL selectin L (lymphocyte adhesion molecule 1)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6402.  
  2. ^ Cotran; Kumar, Collins (1998). Robbins Pathologic Basis of Disease. Philadelphia: W.B Saunders Company. ISBN 0-7216-7335-X.  

External links

Further reading

  • Ryan US, Worthington RE (1992). "Cell-cell contact mechanisms.". Curr. Opin. Immunol. 4 (1): 33–7. doi:10.1016/0952-7915(92)90120-4. PMID 1375831.  
  • Nicholson IC (2003). "CD62L (L-selectin).". J. Biol. Regul. Homeost. Agents 16 (2): 144–6. PMID 12144128.  
  • Ivetic A, Ridley AJ (2005). "The telling tail of L-selectin.". Biochem. Soc. Trans. 32 (Pt 6): 1118–21. doi:10.1042/BST0321118. PMID 15506984.  
  • Lasky LA, Singer MS, Dowbenko D, et al. (1992). "An endothelial ligand for L-selectin is a novel mucin-like molecule.". Cell 69 (6): 927–38. doi:10.1016/0092-8674(92)90612-G. PMID 1376638.  
  • Ord DC, Ernst TJ, Zhou LJ, et al. (1990). "Structure of the gene encoding the human leukocyte adhesion molecule-1 (TQ1, Leu-8) of lymphocytes and neutrophils.". J. Biol. Chem. 265 (14): 7760–7. PMID 1692315.  
  • Bevilacqua M, Butcher E, Furie B, et al. (1991). "Selectins: a family of adhesion receptors.". Cell 67 (2): 233. doi:10.1016/0092-8674(91)90174-W. PMID 1717161.  
  • Tedder TF, Isaacs CM, Ernst TJ, et al. (1989). "Isolation and chromosomal localization of cDNAs encoding a novel human lymphocyte cell surface molecule, LAM-1. Homology with the mouse lymphocyte homing receptor and other human adhesion proteins.". J. Exp. Med. 170 (1): 123–33. doi:10.1084/jem.170.1.123. PMID 2473156.  
  • Camerini D, James SP, Stamenkovic I, Seed B (1989). "Leu-8/TQ1 is the human equivalent of the Mel-14 lymph node homing receptor.". Nature 342 (6245): 78–82. doi:10.1038/342078a0. PMID 2509939.  
  • Bowen BR, Nguyen T, Lasky LA (1989). "Characterization of a human homologue of the murine peripheral lymph node homing receptor.". J. Cell Biol. 109 (1): 421–7. doi:10.1083/jcb.109.1.421. PMID 2663882.  
  • Siegelman MH, Weissman IL (1989). "Human homologue of mouse lymph node homing receptor: evolutionary conservation at tandem cell interaction domains.". Proc. Natl. Acad. Sci. U.S.A. 86 (14): 5562–6. doi:10.1073/pnas.86.14.5562. PMID 2664786.  
  • Bajorath J, Aruffo A (1995). "A template for generation and comparison of three-dimensional selectin models.". Biochem. Biophys. Res. Commun. 216 (3): 1018–23. doi:10.1006/bbrc.1995.2722. PMID 7488174.  
  • Dianzani U, Bragardo M, Buonfiglio D, et al. (1995). "Modulation of CD4 lateral interaction with lymphocyte surface molecules induced by HIV-1 gp120.". Eur. J. Immunol. 25 (5): 1306–11. doi:10.1002/eji.1830250526. PMID 7539755.  
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  
  • Brenner B, Gulbins E, Schlottmann K, et al. (1997). "L-selectin activates the Ras pathway via the tyrosine kinase p56lck.". Proc. Natl. Acad. Sci. U.S.A. 93 (26): 15376–81. doi:10.1073/pnas.93.26.15376. PMID 8986819.  
  • Zöllner O, Lenter MC, Blanks JE, et al. (1997). "L-selectin from human, but not from mouse neutrophils binds directly to E-selectin.". J. Cell Biol. 136 (3): 707–16. doi:10.1083/jcb.136.3.707. PMID 9024699.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  
  • Prakobphol A, Thomsson KA, Hansson GC, et al. (1998). "Human low-molecular-weight salivary mucin expresses the sialyl lewisx determinant and has L-selectin ligand activity.". Biochemistry 37 (14): 4916–27. doi:10.1021/bi972612a. PMID 9538010.  
  • Sassetti C, Tangemann K, Singer MS, et al. (1998). "Identification of podocalyxin-like protein as a high endothelial venule ligand for L-selectin: parallels to CD34.". J. Exp. Med. 187 (12): 1965–75. doi:10.1084/jem.187.12.1965. PMID 9625756.  
  • Malhotra R, Ward M, Sim RB, Bird MI (1999). "Identification of human complement Factor H as a ligand for L-selectin.". Biochem. J. 341 ( Pt 1): 61–9. doi:10.1042/0264-6021:3410061. PMID 10377245.  
  • Bradley LM, Duncan DD,Tonkonogy S, Swain SL (1999). "CD4+ effector T cells in vivo: immunization results in a transient population of MEL-14-, CD45RB- helper cells that secretes interleukin 2 (IL-2), IL-3, IL-4, and interferon gamma.". J. Exp. Med. 174 (3): 547-59. doi:10.1084/jem.174.3.547. PMID 1678774.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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