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L-selectin: Wikis


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Selectin L (lymphocyte adhesion molecule 1)
Symbols SELL; CD62L; LAM-1; LAM1; LECAM1; LNHR; LSEL; LYAM1; Leu-8; Lyam-1; PLNHR; TQ1; hLHRc; MEL14; MEL-14
External IDs OMIM153240 MGI98279 HomoloGene539 GeneCards: SELL Gene
RNA expression pattern
PBB GE SELL 204563 at tn.png
More reference expression data
Species Human Mouse
Entrez 6402 20343
Ensembl ENSG00000188404 ENSMUSG00000026581
UniProt P14151 Q3TA36
RefSeq (mRNA) NM_000655 NM_011346
RefSeq (protein) NP_000646 NP_035476
Location (UCSC) Chr 1:
167.93 - 167.95 Mb
Chr 1:
165.9 - 165.91 Mb
PubMed search [1] [2]

L-selectin, also known as CD62L, is a cell adhesion molecule found on leukocytes. It belongs to the selectin family of proteins, which recognise sialylated carbohydrate groups. It is cleaved by ADAM17.

SELL is a cell surface component that is a member of a family of adhesion/homing receptors which play important roles in leukocyte-endothelial cell interactions. The molecule is composed of multiple domains: one homologous to lectins, one to epidermal growth factor, and two to the consensus repeat units found in C3/C4 binding proteins.[1]




L-selectin acts as a "homing receptor" for leukocytes to enter secondary lymphoid tissues via high endothelial venules. Ligands present on endothelial cells will bind to leukocyte expressing L-selectin, slowing leukocyte trafficking through the blood, and facilitating entry into a secondary lymphoid organ at that point[2]. The receptor is commonly found on the cell surfaces of T cells. Naive T-lymphocytes, which have not yet encountered their specific antigen, need to enter secondary lymph nodes to encounter their antigen. Central memory T-lymphocytes, which have encountered antigen, express L-selectin to localize in secondary lymphoid organs. Here they reside ready to proliferate upon re-encountering antigen. Effector memory T-lymphocytes do not express L-selectin. These cells circulate in the periphery, so they do not express L-selectin, and have immediate effector functions upon encountering antigen.


  1. ^ "Entrez Gene: SELL selectin L (lymphocyte adhesion molecule 1)".  
  2. ^ Cotran; Kumar, Collins (1998). Robbins Pathologic Basis of Disease. Philadelphia: W.B Saunders Company. ISBN 0-7216-7335-X.  

External links

Further reading

  • Ryan US, Worthington RE (1992). "Cell-cell contact mechanisms.". Curr. Opin. Immunol. 4 (1): 33–7. doi:10.1016/0952-7915(92)90120-4. PMID 1375831.  
  • Nicholson IC (2003). "CD62L (L-selectin).". J. Biol. Regul. Homeost. Agents 16 (2): 144–6. PMID 12144128.  
  • Ivetic A, Ridley AJ (2005). "The telling tail of L-selectin.". Biochem. Soc. Trans. 32 (Pt 6): 1118–21. doi:10.1042/BST0321118. PMID 15506984.  
  • Lasky LA, Singer MS, Dowbenko D, et al. (1992). "An endothelial ligand for L-selectin is a novel mucin-like molecule.". Cell 69 (6): 927–38. doi:10.1016/0092-8674(92)90612-G. PMID 1376638.  
  • Ord DC, Ernst TJ, Zhou LJ, et al. (1990). "Structure of the gene encoding the human leukocyte adhesion molecule-1 (TQ1, Leu-8) of lymphocytes and neutrophils.". J. Biol. Chem. 265 (14): 7760–7. PMID 1692315.  
  • Bevilacqua M, Butcher E, Furie B, et al. (1991). "Selectins: a family of adhesion receptors.". Cell 67 (2): 233. doi:10.1016/0092-8674(91)90174-W. PMID 1717161.  
  • Tedder TF, Isaacs CM, Ernst TJ, et al. (1989). "Isolation and chromosomal localization of cDNAs encoding a novel human lymphocyte cell surface molecule, LAM-1. Homology with the mouse lymphocyte homing receptor and other human adhesion proteins.". J. Exp. Med. 170 (1): 123–33. doi:10.1084/jem.170.1.123. PMID 2473156.  
  • Camerini D, James SP, Stamenkovic I, Seed B (1989). "Leu-8/TQ1 is the human equivalent of the Mel-14 lymph node homing receptor.". Nature 342 (6245): 78–82. doi:10.1038/342078a0. PMID 2509939.  
  • Bowen BR, Nguyen T, Lasky LA (1989). "Characterization of a human homologue of the murine peripheral lymph node homing receptor.". J. Cell Biol. 109 (1): 421–7. doi:10.1083/jcb.109.1.421. PMID 2663882.  
  • Siegelman MH, Weissman IL (1989). "Human homologue of mouse lymph node homing receptor: evolutionary conservation at tandem cell interaction domains.". Proc. Natl. Acad. Sci. U.S.A. 86 (14): 5562–6. doi:10.1073/pnas.86.14.5562. PMID 2664786.  
  • Bajorath J, Aruffo A (1995). "A template for generation and comparison of three-dimensional selectin models.". Biochem. Biophys. Res. Commun. 216 (3): 1018–23. doi:10.1006/bbrc.1995.2722. PMID 7488174.  
  • Dianzani U, Bragardo M, Buonfiglio D, et al. (1995). "Modulation of CD4 lateral interaction with lymphocyte surface molecules induced by HIV-1 gp120.". Eur. J. Immunol. 25 (5): 1306–11. doi:10.1002/eji.1830250526. PMID 7539755.  
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  
  • Brenner B, Gulbins E, Schlottmann K, et al. (1997). "L-selectin activates the Ras pathway via the tyrosine kinase p56lck.". Proc. Natl. Acad. Sci. U.S.A. 93 (26): 15376–81. doi:10.1073/pnas.93.26.15376. PMID 8986819.  
  • Zöllner O, Lenter MC, Blanks JE, et al. (1997). "L-selectin from human, but not from mouse neutrophils binds directly to E-selectin.". J. Cell Biol. 136 (3): 707–16. doi:10.1083/jcb.136.3.707. PMID 9024699.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  
  • Prakobphol A, Thomsson KA, Hansson GC, et al. (1998). "Human low-molecular-weight salivary mucin expresses the sialyl lewisx determinant and has L-selectin ligand activity.". Biochemistry 37 (14): 4916–27. doi:10.1021/bi972612a. PMID 9538010.  
  • Sassetti C, Tangemann K, Singer MS, et al. (1998). "Identification of podocalyxin-like protein as a high endothelial venule ligand for L-selectin: parallels to CD34.". J. Exp. Med. 187 (12): 1965–75. doi:10.1084/jem.187.12.1965. PMID 9625756.  
  • Malhotra R, Ward M, Sim RB, Bird MI (1999). "Identification of human complement Factor H as a ligand for L-selectin.". Biochem. J. 341 ( Pt 1): 61–9. doi:10.1042/0264-6021:3410061. PMID 10377245.  
  • Bradley LM, Duncan DD,Tonkonogy S, Swain SL (1999). "CD4+ effector T cells in vivo: immunization results in a transient population of MEL-14-, CD45RB- helper cells that secretes interleukin 2 (IL-2), IL-3, IL-4, and interferon gamma.". J. Exp. Med. 174 (3): 547-59. doi:10.1084/jem.174.3.547. PMID 1678774.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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