The Full Wiki

More info on L-type calcium channel

L-type calcium channel: Wikis


Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.


From Wikipedia, the free encyclopedia

The L-type calcium channel is a type of voltage-dependent calcium channel. "L" stands for long-lasting referring to the length of activation. Like the others of this class, the α1 subunit is the one that determines most of the channel's properties.

L-type calcium channel blocker drugs are used as cardiac antiarrhythmics or antihypertensives, depending on whether the drugs has higher affinity to the heart, the phenylalkylamines (like verapamil) or to the vessels, the dihydropyridines (nifedipine).

L-type channels are selectively blocked by benzothiazepines (like diltiazem).


See also

In skeletal muscle, there is a very high concentration of DHP receptors, representing L-type calcium channels, situated in the T-tubules. Muscle depolarization results in large gating currents, but anomalously low calcium flux, which is now explained by the very slow activation of the ionic currents. For this reason, little or no Ca2+ passes across the T-tubule membrane during a single action potential.


See also

External links



Got something to say? Make a comment.
Your name
Your email address