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Lymphocyte-activation gene 3
Symbols LAG3; CD223
External IDs OMIM153337 MGI106588 HomoloGene1719 GeneCards: LAG3 Gene
RNA expression pattern
PBB GE LAG3 206486 at tn.png
More reference expression data
Species Human Mouse
Entrez 3902 16768
Ensembl ENSG00000089692 ENSMUSG00000030124
UniProt P18627 Q61790
RefSeq (mRNA) NM_002286 XM_981508
RefSeq (protein) NP_002277 XP_986602
Location (UCSC) Chr 12:
6.75 - 6.76 Mb
Chr 6:
124.87 - 124.88 Mb
PubMed search [1] [2]

Lymphocyte-activation gene 3, also known as LAG3, is a protein which in humans is encoded by the LAG3 gene.[1][2] LAG3 has also recently been designated CD223 (cluster of differentiation 223).

Lymphocyte-activation protein 3 belongs to immunoglobulin (Ig) superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4.[1]


  1. ^ a b "Entrez Gene: LAG3 lymphocyte-activation gene 3".  
  2. ^ Triebel F, Jitsukawa S, Baixeras E, Roman-Roman S, Genevee C, Viegas-Pequignot E, Hercend T (May 1990). "LAG-3, a novel lymphocyte activation gene closely related to CD4". J. Exp. Med. 171 (5): 1393–405. doi:10.1084/jem.171.5.1393. PMID 1692078.  

Further reading

  • Triebel F (2004). "LAG-3: a regulator of T-cell and DC responses and its use in therapeutic vaccination.". Trends Immunol. 24 (12): 619–22. doi:10.1016/ PMID 14644131.  
  • Baixeras E, Huard B, Miossec C, et al. (1992). "Characterization of the lymphocyte activation gene 3-encoded protein. A new ligand for human leukocyte antigen class II antigens.". J. Exp. Med. 176 (2): 327–37. doi:10.1084/jem.176.2.327. PMID 1380059.  
  • Triebel F, Jitsukawa S, Baixeras E, et al. (1990). "LAG-3, a novel lymphocyte activation gene closely related to CD4.". J. Exp. Med. 171 (5): 1393–405. doi:10.1084/jem.171.5.1393. PMID 1692078.  
  • Blum MD, Wong GT, Higgins KM, et al. (1993). "Reconstitution of the subclass-specific expression of CD4 in thymocytes and peripheral T cells of transgenic mice: identification of a human CD4 enhancer.". J. Exp. Med. 177 (5): 1343–58. doi:10.1084/jem.177.5.1343. PMID 8097522.  
  • Huard B, Mastrangeli R, Prigent P, et al. (1997). "Characterization of the major histocompatibility complex class II binding site on LAG-3 protein.". Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5744–9. doi:10.1073/pnas.94.11.5744. PMID 9159144.  
  • Bruniquel D, Borie N, Triebel F (1998). "Genomic organization of the human LAG-3/CD4 locus.". Immunogenetics 47 (1): 96–8. doi:10.1007/s002510050332. PMID 9382927.  
  • Bruniquel D, Borie N, Hannier S, Triebel F (1998). "Regulation of expression of the human lymphocyte activation gene-3 (LAG-3) molecule, a ligand for MHC class II.". Immunogenetics 48 (2): 116–24. doi:10.1007/s002510050411. PMID 9634475.  
  • Hannier S, Tournier M, Bismuth G, Triebel F (1998). "CD3/TCR complex-associated lymphocyte activation gene-3 molecules inhibit CD3/TCR signaling.". J. Immunol. 161 (8): 4058–65. PMID 9780176.  
  • Hannier S, Triebel F (1999). "The MHC class II ligand lymphocyte activation gene-3 is co-distributed with CD8 and CD3-TCR molecules after their engagement by mAb or peptide-MHC class I complexes.". Int. Immunol. 11 (11): 1745–52. doi:10.1093/intimm/11.11.1745. PMID 10545478.  
  • Iouzalen N, Andreae S, Hannier S, Triebel F (2001). "LAP, a lymphocyte activation gene-3 (LAG-3)-associated protein that binds to a repeated EP motif in the intracellular region of LAG-3, may participate in the down-regulation of the CD3/TCR activation pathway.". Eur. J. Immunol. 31 (10): 2885–91. doi:10.1002/1521-4141(2001010)31:10<2885::AID-IMMU2885>3.0.CO;2-2. PMID 11592063.  
  • Andreae S, Piras F, Burdin N, Triebel F (2002). "Maturation and activation of dendritic cells induced by lymphocyte activation gene-3 (CD223).". J. Immunol. 168 (8): 3874–80. PMID 11937541.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Andreae S, Buisson S, Triebel F (2003). "MHC class II signal transduction in human dendritic cells induced by a natural ligand, the LAG-3 protein (CD223).". Blood 102 (6): 2130–7. doi:10.1182/blood-2003-01-0273. PMID 12775570.  
  • Cai XF, Tao Z, Yan ZQ, et al. (2004). "Molecular cloning, characterisation and tissue-specific expression of human LAG3, a member of the novel Lag1 protein family.". DNA Seq. 14 (2): 79–86. PMID 12825348.  
  • Gandhi MK, Lambley E, Duraiswamy J, et al. (2006). "Expression of LAG-3 by tumor-infiltrating lymphocytes is coincident with the suppression of latent membrane antigen-specific CD8+ T-cell function in Hodgkin lymphoma patients.". Blood 108 (7): 2280–9. doi:10.1182/blood-2006-04-015164. PMID 16757686.  
  • Lundmark F, Harbo HF, Celius EG, et al. (2007). "Association analysis of the LAG3 and CD4 genes in multiple sclerosis in two independent populations.". J. Neuroimmunol. 180 (1-2): 193–8. doi:10.1016/j.jneuroim.2006.08.009. PMID 17020785.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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