The Full Wiki

LAIR1: Wikis


Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.


From Wikipedia, the free encyclopedia

Leukocyte-associated immunoglobulin-like receptor 1
Symbols LAIR1; CD305; LAIR-1
External IDs OMIM602992 MGI105492 HomoloGene48097 GeneCards: LAIR1 Gene
RNA expression pattern
PBB GE LAIR1 210644 s at tn.png
PBB GE LAIR1 208071 s at tn.png
More reference expression data
Species Human Mouse
Entrez 3903 52855
Ensembl ENSG00000167613 ENSMUSG00000055541
UniProt Q6GTX8 Q8BG84
RefSeq (mRNA) NM_002287 NM_178611
RefSeq (protein) NP_002278 NP_848726
Location (UCSC) Chr 19:
59.56 - 59.57 Mb
Chr 7:
3.61 - 3.67 Mb
PubMed search [1] [2]

Leukocyte-associated immunoglobulin-like receptor 1 is a protein that in humans is encoded by the LAIR1 gene.[1][2] LAIR1 has also been designated as CD305 (cluster of differentiation 305).

The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily.[2]



LAIR1 has been shown to interact with PTPN11[3][1] and PTPN6.[4][3][1][5][6]


  1. ^ a b c Meyaard L, Adema GJ, Chang C, Woollatt E, Sutherland GR, Lanier LL, Phillips JH (Sep 1997). "LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes". Immunity 7 (2): 283–90. PMID 9285412.  
  2. ^ a b "Entrez Gene: LAIR1 leukocyte-associated immunoglobulin-like receptor 1".  
  3. ^ a b Fournier, N; Chalus L, Durand I, Garcia E, Pin J J, Churakova T, Patel S, Zlot C, Gorman D, Zurawski S, Abrams J, Bates E E, Garrone P (Aug. 2000). "FDF03, a novel inhibitory receptor of the immunoglobulin superfamily, is expressed by human dendritic and myeloid cells". J. Immunol. (UNITED STATES) 165 (3): 1197–209. ISSN 0022-1767. PMID 10903717.  
  4. ^ Sathish, J G; Johnson K G, Fuller K J, LeRoy F G, Meyaard L, Sims M J, Matthews R J (Feb. 2001). "Constitutive association of SHP-1 with leukocyte-associated Ig-like receptor-1 in human T cells". J. Immunol. (United States) 166 (3): 1763–70. ISSN 0022-1767. PMID 11160222.  
  5. ^ Mousseau, D D; Banville D, L'Abbé D, Bouchard P, Shen S H (Feb. 2000). "PILRalpha, a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILRbeta". J. Biol. Chem. (UNITED STATES) 275 (6): 4467–74. ISSN 0021-9258. PMID 10660620.  
  6. ^ Xu, M j; Zhao R, Zhao Z J (Jun. 2000). "Identification and characterization of leukocyte-associated Ig-like receptor-1 as a major anchor protein of tyrosine phosphatase SHP-1 in hematopoietic cells". J. Biol. Chem. (UNITED STATES) 275 (23): 17440–6. doi:10.1074/jbc.M001313200. ISSN 0021-9258. PMID 10764762.  

Further reading

  • Sinclair NR (1999). "Why so many coinhibitory receptors?". Scand. J. Immunol. 50 (1): 10–3. doi:10.1046/j.1365-3083.1999.00580.x. PMID 10404045.  
  • Meyaard L (1999). "LAIR-1, a widely distributed human ITIM-bearing receptor on hematopoietic cells.". Curr. Top. Microbiol. Immunol. 244: 151–7. PMID 10453657.  
  • Meyaard L (2004). "Leukocyte associated Ig-like receptor (LAIR).". J. Biol. Regul. Homeost. Agents 17 (4): 330–3. PMID 15065762.  
  • Poggi A, Tomasello E, Ferrero E, et al. (1998). "p40/LAIR-1 regulates the differentiation of peripheral blood precursors to dendritic cells induced by granulocyte-monocyte colony-stimulating factor.". Eur. J. Immunol. 28 (7): 2086–91. doi:10.1002/(SICI)1521-4141(199807)28:07<2086::AID-IMMU2086>3.0.CO;2-T. PMID 9692876.  
  • Meyaard L, Hurenkamp J, Clevers H, et al. (1999). "Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells.". J. Immunol. 162 (10): 5800–4. PMID 10229813.  
  • van der Vuurst de Vries AR, Clevers H, Logtenberg T, Meyaard L (1999). "Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is differentially expressed during human B cell differentiation and inhibits B cell receptor-mediated signaling.". Eur. J. Immunol. 29 (10): 3160–7. doi:10.1002/(SICI)1521-4141(199910)29:10<3160::AID-IMMU3160>3.0.CO;2-S. PMID 10540327.  
  • Xu M, Zhao R, Zhao ZJ (2000). "Identification and characterization of leukocyte-associated Ig-like receptor-1 as a major anchor protein of tyrosine phosphatase SHP-1 in hematopoietic cells.". J. Biol. Chem. 275 (23): 17440–6. doi:10.1074/jbc.M001313200. PMID 10764762.  
  • Poggi A, Pellegatta F, Leone BE, et al. (2000). "Engagement of the leukocyte-associated Ig-like receptor-1 induces programmed cell death and prevents NF-kappaB nuclear translocation in human myeloid leukemias.". Eur. J. Immunol. 30 (10): 2751–8. doi:10.1002/1521-4141(200010)30:10<2751::AID-IMMU2751>3.0.CO;2-L. PMID 11069054.  
  • Sathish JG, Johnson KG, Fuller KJ, et al. (2001). "Constitutive association of SHP-1 with leukocyte-associated Ig-like receptor-1 in human T cells.". J. Immunol. 166 (3): 1763–70. PMID 11160222.  
  • Meyaard L, van der Vuurst de Vries AR, de Ruiter T, et al. (2001). "The epithelial cellular adhesion molecule (Ep-CAM) is a ligand for the leukocyte-associated immunoglobulin-like receptor (LAIR).". J. Exp. Med. 194 (1): 107–12. doi:10.1084/jem.194.1.107. PMID 11435477.  
  • Saverino D, Fabbi M, Merlo A, et al. (2002). "Surface density expression of the leukocyte-associated Ig-like receptor-1 is directly related to inhibition of human T-cell functions.". Hum. Immunol. 63 (7): 534–46. doi:10.1016/S0198-8859(02)00409-3. PMID 12072189.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Aoukaty A, Lee IF, Wu J, Tan R (2004). "Chronic active Epstein-Barr virus infection associated with low expression of leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) on natural killer cells.". J. Clin. Immunol. 23 (2): 141–5. doi:10.1023/A:1022580929226. PMID 12757266.  
  • Verbrugge A, Ruiter Td T, Clevers H, Meyaard L (2004). "Differential contribution of the immunoreceptor tyrosine-based inhibitory motifs of human leukocyte-associated Ig-like receptor-1 to inhibitory function and phosphatase recruitment.". Int. Immunol. 15 (11): 1349–58. doi:10.1093/intimm/dxg134. PMID 14565933.  
  • De Milito A, Nilsson A, Titanji K, et al. (2004). "Mechanisms of hypergammaglobulinemia and impaired antigen-specific humoral immunity in HIV-1 infection.". Blood 103 (6): 2180–6. doi:10.1182/blood-2003-07-2375. PMID 14604962.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



Got something to say? Make a comment.
Your name
Your email address