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Leukocyte-associated immunoglobulin-like receptor 2
Identifiers
Symbols LAIR2; CD306; MGC71634
External IDs OMIM602993 HomoloGene88663 GeneCards: LAIR2 Gene
RNA expression pattern
PBB GE LAIR2 207509 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3904 n/a
Ensembl ENSG00000167618 n/a
UniProt Q6ISS4 n/a
RefSeq (mRNA) NM_002288 n/a
RefSeq (protein) NP_002279 n/a
Location (UCSC) Chr 19:
59.71 - 59.71 Mb
n/a
PubMed search [1] n/a

Leukocyte-associated immunoglobulin-like receptor 2 is a protein that in humans is encoded by the LAIR2 gene.[1][2]

The protein encoded by this gene is a member of the immunoglobulin superfamily. It was identified by its similarity to LAIR1, an inhibitory receptor present on mononuclear leukocytes. This gene maps to a region of 19q13.4, termed the leukocyte receptor cluster, which contains 29 genes in the immunoglobulin superfamily, including LAIR1. The function of this protein is unknown, although it is thought to be secreted and may help modulate mucosal tolerance. Two transcript variants encoding different isoforms have been found for this gene.[2]

References

  1. ^ Meyaard L, Adema GJ, Chang C, Woollatt E, Sutherland GR, Lanier LL, Phillips JH (Sep 1997). "LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes". Immunity 7 (2): 283-90. PMID 9285412.  
  2. ^ a b "Entrez Gene: LAIR2 leukocyte-associated immunoglobulin-like receptor 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3904.  

Further reading

  • Lebbink RJ, van den Berg MC, de Ruiter T, et al. (2008). "The soluble leukocyte-associated Ig-like receptor (LAIR)-2 antagonizes the collagen/LAIR-1 inhibitory immune interaction.". J. Immunol. 180 (3): 1662–9. PMID 18209062.  
  • Denoeud F, Kapranov P, Ucla C, et al. (2007). "Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions.". Genome Res. 17 (6): 746–59. doi:10.1101/gr.5660607. PMID 17567994.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Meyaard L, van der Vuurst de Vries AR, de Ruiter T, et al. (2001). "The epithelial cellular adhesion molecule (Ep-CAM) is a ligand for the leukocyte-associated immunoglobulin-like receptor (LAIR).". J. Exp. Med. 194 (1): 107–12. doi:10.1084/jem.194.1.107. PMID 11435477.  
  • Wende H, Volz A, Ziegler A (2000). "Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster.". Immunogenetics 51 (8-9): 703–13. doi:10.1007/s002510000187. PMID 10941842.  
  • Meyaard L, Hurenkamp J, Clevers H, et al. (1999). "Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells.". J. Immunol. 162 (10): 5800–4. PMID 10229813.  
  • Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.  
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