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Lysosomal-associated membrane protein 1
Symbols LAMP1; CD107a; LAMPA; LGP120
External IDs OMIM153330 MGI96745 HomoloGene4061 GeneCards: LAMP1 Gene
RNA expression pattern
PBB GE LAMP1 201553 s at tn.png
PBB GE LAMP1 201551 s at tn.png
PBB GE LAMP1 201552 at tn.png
More reference expression data
Species Human Mouse
Entrez 3916 16783
Ensembl ENSG00000185896 ENSMUSG00000031447
UniProt P11279 Q3TA96
RefSeq (mRNA) NM_005561 NM_010684
RefSeq (protein) NP_005552 NP_034814
Location (UCSC) Chr 13:
113 - 113.03 Mb
Chr 8:
13.16 - 13.18 Mb
PubMed search [1] [2]

Lysosomal-associated membrane protein 1 (LAMP1) also known as CD107a (Cluster of Differentiation 107a) , is a human gene.[1]

The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis.[1]


See also


Further reading

  • Chang MH, Karageorgos LE, Meikle PJ (2003). "CD107a (LAMP-1) and CD107b (LAMP-2).". J. Biol. Regul. Homeost. Agents 16 (2): 147–51. PMID 12144129.  
  • Schleutker J, Haataja L, Renlund M, et al. (1992). "Confirmation of the chromosomal localization of human lamp genes and their exclusion as candidate genes for Salla disease.". Hum. Genet. 88 (1): 95–7. doi:10.1007/BF00204936. PMID 1959930.  
  • Carlsson SR, Fukuda M (1990). "The polylactosaminoglycans of human lysosomal membrane glycoproteins lamp-1 and lamp-2. Localization on the peptide backbones.". J. Biol. Chem. 265 (33): 20488–95. PMID 2243102.  
  • Mattei MG, Matterson J, Chen JW, et al. (1990). "Two human lysosomal membrane glycoproteins, h-lamp-1 and h-lamp-2, are encoded by genes localized to chromosome 13q34 and chromosome Xq24-25, respectively.". J. Biol. Chem. 265 (13): 7548–51. PMID 2332441.  
  • Carlsson SR, Fukuda M (1990). "Structure of human lysosomal membrane glycoprotein 1. Assignment of disulfide bonds and visualization of its domain arrangement.". J. Biol. Chem. 264 (34): 20526–31. PMID 2584229.  
  • Mane SM, Marzella L, Bainton DF, et al. (1989). "Purification and characterization of human lysosomal membrane glycoproteins.". Arch. Biochem. Biophys. 268 (1): 360–78. doi:10.1016/0003-9861(89)90597-3. PMID 2912382.  
  • Viitala J, Carlsson SR, Siebert PD, Fukuda M (1988). "Molecular cloning of cDNAs encoding lamp A, a human lysosomal membrane glycoprotein with apparent Mr approximately equal to 120,000.". Proc. Natl. Acad. Sci. U.S.A. 85 (11): 3743–7. doi:10.1073/pnas.85.11.3743. PMID 3131762.  
  • Howe CL, Granger BL, Hull M, et al. (1988). "Derived protein sequence, oligosaccharides, and membrane insertion of the 120-kDa lysosomal membrane glycoprotein (lgp120): identification of a highly conserved family of lysosomal membrane glycoproteins.". Proc. Natl. Acad. Sci. U.S.A. 85 (20): 7577–81. doi:10.1073/pnas.85.20.7577. PMID 3174652.  
  • Fukuda M, Viitala J, Matteson J, Carlsson SR (1989). "Cloning of cDNAs encoding human lysosomal membrane glycoproteins, h-lamp-1 and h-lamp-2. Comparison of their deduced amino acid sequences.". J. Biol. Chem. 263 (35): 18920–8. PMID 3198605.  
  • Ohno H, Stewart J, Fournier MC, et al. (1995). "Interaction of tyrosine-based sorting signals with clathrin-associated proteins.". Science 269 (5232): 1872–5. doi:10.1126/science.7569928. PMID 7569928.  
  • Carlsson SR, Lycksell PO, Fukuda M (1993). "Assignment of O-glycan attachment sites to the hinge-like regions of human lysosomal membrane glycoproteins lamp-1 and lamp-2.". Arch. Biochem. Biophys. 304 (1): 65–73. doi:10.1006/abbi.1993.1322. PMID 8323299.  
  • Sawada R, Jardine KA, Fukuda M (1993). "The genes of major lysosomal membrane glycoproteins, lamp-1 and lamp-2. 5'-flanking sequence of lamp-2 gene and comparison of exon organization in two genes.". J. Biol. Chem. 268 (12): 9014–22. PMID 8517882.  
  • Rohrer J, Schweizer A, Russell D, Kornfeld S (1996). "The targeting of Lamp1 to lysosomes is dependent on the spacing of its cytoplasmic tail tyrosine sorting motif relative to the membrane.". J. Cell Biol. 132 (4): 565–76. doi:10.1083/jcb.132.4.565. PMID 8647888.  
  • Höning S, Sandoval IV, von Figura K (1998). "A di-leucine-based motif in the cytoplasmic tail of LIMP-II and tyrosinase mediates selective binding of AP-3.". Embo J. 17 (5): 1304–14. doi:10.1093/emboj/17.5.1304. PMID 9482728.  
  • Furuta K, Yang XL, Chen JS, et al. (1999). "Differential expression of the lysosome-associated membrane proteins in normal human tissues.". Arch. Biochem. Biophys. 365 (1): 75–82. doi:10.1006/abbi.1999.1147. PMID 10222041.  
  • Raposo G, Moore M, Innes D, et al. (2003). "Human macrophages accumulate HIV-1 particles in MHC II compartments.". Traffic 3 (10): 718–29. doi:10.1034/j.1600-0854.2002.31004.x. PMID 12230470.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Zhang H, Li XJ, Martin DB, Aebersold R (2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.". Nat. Biotechnol. 21 (6): 660–6. doi:10.1038/nbt827. PMID 12754519.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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