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Lysosomal-associated membrane protein 3
Identifiers
Symbols LAMP3; LAMP; CD208; DC-LAMP; DCLAMP; TSC403
External IDs OMIM605883 MGI2441659 HomoloGene8670 GeneCards: LAMP3 Gene
RNA expression pattern
PBB GE LAMP3 205569 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 27074 239739
Ensembl ENSG00000078081 ENSMUSG00000041247
UniProt Q9UQV4 Q7TST5
RefSeq (mRNA) NM_014398 NM_177356
RefSeq (protein) NP_055213 NP_796330
Location (UCSC) Chr 3:
184.32 - 184.36 Mb
Chr 16:
19.57 - 19.62 Mb
PubMed search [1] [2]

Lysosome-associated membrane glycoprotein 3 is a protein that in humans is encoded by the LAMP3 gene.[1][2]

LAMP3 has also recently been designated CD208 (cluster of differentiation 208).

References

  1. ^ Ozaki K, Nagata M, Suzuki M, Fujiwara T, Ueda K, Miyoshi Y, Takahashi E, Nakamura Y (Sep 1998). "Isolation and characterization of a novel human lung-specific gene homologous to lysosomal membrane glycoproteins 1 and 2: significantly increased expression in cancers of various tissues". Cancer Res 58 (16): 3499-503. PMID 9721848.  
  2. ^ "Entrez Gene: LAMP3 lysosomal-associated membrane protein 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27074.  

Further reading

  • de Saint-Vis B, Vincent J, Vandenabeele S, et al. (1998). "A novel lysosome-associated membrane glycoprotein, DC-LAMP, induced upon DC maturation, is transiently expressed in MHC class II compartment.". Immunity 9 (3): 325–36. doi:10.1016/S1074-7613(00)80615-9. PMID 9768752.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Akasaki K, Nakamura N, Tsukui N, et al. (2004). "Human dendritic cell lysosome-associated membrane protein expressed in lung type II pneumocytes.". Arch. Biochem. Biophys. 425 (2): 147–57. doi:10.1016/j.abb.2004.02.042. PMID 15111122.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Kanao H, Enomoto T, Kimura T, et al. (2005). "Overexpression of LAMP3/TSC403/DC-LAMP promotes metastasis in uterine cervical cancer.". Cancer Res. 65 (19): 8640–5. doi:10.1158/0008-5472.CAN-04-4112. PMID 16204031.  
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.  
  • Arruda LB, Sim D, Chikhlikar PR, et al. (2006). "Dendritic cell-lysosomal-associated membrane protein (LAMP) and LAMP-1-HIV-1 gag chimeras have distinct cellular trafficking pathways and prime T and B cell responses to a diverse repertoire of epitopes.". J. Immunol. 177 (4): 2265–75. PMID 16887987.  
  • Zhu LC, Yim J, Chiriboga L, et al. (2007). "DC-LAMP stains pulmonary adenocarcinoma with bronchiolar Clara cell differentiation.". Hum. Pathol. 38 (2): 260–8. doi:10.1016/j.humpath.2006.07.018. PMID 17056097.  
  • Elliott B, Scolyer RA, Suciu S, et al. (2007). "Long-term protective effect of mature DC-LAMP+ dendritic cell accumulation in sentinel lymph nodes containing micrometastatic melanoma.". Clin. Cancer Res. 13 (13): 3825–30. doi:10.1158/1078-0432.CCR-07-0358. PMID 17606713.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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