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LDL-receptor-related protein associated protein: Wikis

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Low density lipoprotein receptor-related protein associated protein 1

PDB rendering based on 1lre.
Available structures
1lre, 1nre, 1op1, 1ov2, 2fcw, 2ftu, 2fyl
Identifiers
Symbols LRPAP1; A2MRAP; A2RAP; HBP44; MGC138272; MRAP; RAP
External IDs OMIM104225 MGI96829 HomoloGene37612 GeneCards: LRPAP1 Gene
RNA expression pattern
PBB GE LRPAP1 201186 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4043 16976
Ensembl ENSG00000163956 ENSMUSG00000029103
UniProt P30533 Q3TL96
RefSeq (mRNA) NM_002337 NM_013587
RefSeq (protein) NP_002328 NP_038615
Location (UCSC) Chr 4:
3.48 - 3.5 Mb
Chr 5:
35.41 - 35.42 Mb
PubMed search [1] [2]

Low density lipoprotein receptor-related protein associated protein 1 also known as LRPAP1 or RAP is a chaperone protein which in humans is encoded by the LRPAP1 gene.[1][2]

Contents

Function

LRPAP1 is involved with trafficking of certain members of the LDL receptor family including LRP1 and LRP2.[3]

Interactions

LDL-receptor-related protein associated protein has been shown to interact with LRP2.[4][5]

References

  1. ^ Striekland DK, Ashcom JD, Williams S, Battey F, Behre E, McTigue K, Battey JF, Argraves WS (July 1991). "Primary structure of alpha 2-macroglobulin receptor-associated protein. Human homologue of a Heymann nephritis antigen". J. Biol. Chem. 266 (20): 13364–9. PMID 1712782. http://www.jbc.org/cgi/content/abstract/266/20/13364.  
  2. ^ Korenberg JR, Argraves KM, Chen XN, Tran H, Strickland DK, Argraves WS (July 1994). "Chromosomal localization of human genes for the LDL receptor family member glycoprotein 330 (LRP2) and its associated protein RAP (LRPAP1)". Genomics 22 (1): 88–93. doi:10.1006/geno.1994.1348. PMID 7959795.  
  3. ^ "Entrez Gene: LRPAP1 low density lipoprotein receptor-related protein associated protein 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4043.  
  4. ^ Lou, Xiaojing; McQuistan Tammie, Orlando Robert A, Farquhar Marilyn Gist (Apr. 2002). "GAIP, GIPC and Galphai3 are concentrated in endocytic compartments of proximal tubule cells: putative role in regulating megalin's function". J. Am. Soc. Nephrol. (United States) 13 (4): 918–27. ISSN 1046-6673. PMID 11912251.  
  5. ^ Orlando, R A; Farquhar M G (Apr. 1994). "Functional domains of the receptor-associated protein (RAP)". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 91 (8): 3161–5. ISSN 0027-8424. PMID 7512726.  

Further reading

  • Williams SE, Ashcom JD, Argraves WS, Strickland DK (1992). "A novel mechanism for controlling the activity of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Multiple regulatory sites for 39-kDa receptor-associated protein.". J. Biol. Chem. 267 (13): 9035–40. PMID 1374383.  
  • Kounnas MZ, Argraves WS, Strickland DK (1992). "The 39-kDa receptor-associated protein interacts with two members of the low density lipoprotein receptor family, alpha 2-macroglobulin receptor and glycoprotein 330.". J. Biol. Chem. 267 (29): 21162–6. PMID 1400426.  
  • Striekland DK, Ashcom JD, Williams S, et al. (1991). "Primary structure of alpha 2-macroglobulin receptor-associated protein. Human homologue of a Heymann nephritis antigen.". J. Biol. Chem. 266 (20): 13364–9. PMID 1712782.  
  • Herz J, Goldstein JL, Strickland DK, et al. (1991). "39-kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor.". J. Biol. Chem. 266 (31): 21232–8. PMID 1718973.  
  • Furukawa T, Ozawa M, Huang RP, Muramatsu T (1990). "A heparin binding protein whose expression increases during differentiation of embryonal carcinoma cells to parietal endoderm cells: cDNA cloning and sequence analysis.". J. Biochem. 108 (2): 297–302. PMID 2229028.  
  • Herz J, Hamann U, Rogne S, et al. (1989). "Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor.". Embo J. 7 (13): 4119–27. PMID 3266596.  
  • Zheng G, Bachinsky DR, Stamenkovic I, et al. (1994). "Organ distribution in rats of two members of the low-density lipoprotein receptor gene family, gp330 and LRP/alpha 2MR, and the receptor-associated protein (RAP).". J. Histochem. Cytochem. 42 (4): 531–42. PMID 7510321.  
  • Orlando RA, Farquhar MG (1994). "Functional domains of the receptor-associated protein (RAP).". Proc. Natl. Acad. Sci. U.S.A. 91 (8): 3161–5. PMID 7512726.  
  • Jou YS, Goold RD, Myers RM (1995). "Localization of the alpha 2-macroglobulin receptor-associated protein 1 gene (LRPAP1) and other gene fragments to human chromosome 4p16.3 by direct cDNA selection.". Genomics 24 (2): 410–3. doi:10.1006/geno.1994.1643. PMID 7535288.  
  • Argraves KM, Battey FD, MacCalman CD, et al. (1995). "The very low density lipoprotein receptor mediates the cellular catabolism of lipoprotein lipase and urokinase-plasminogen activator inhibitor type I complexes.". J. Biol. Chem. 270 (44): 26550–7. doi:10.1074/jbc.270.44.26550. PMID 7592875.  
  • Bu G, Geuze HJ, Strous GJ, Schwartz AL (1995). "39 kDa receptor-associated protein is an ER resident protein and molecular chaperone for LDL receptor-related protein.". Embo J. 14 (10): 2269–80. PMID 7774585.  
  • Van Leuven F, Hilliker C, Serneels L, et al. (1995). "Cloning, characterization, and chromosomal localization to 4p16 of the human gene (LRPAP1) coding for the alpha 2-macroglobulin receptor-associated protein and structural comparison with the murine gene coding for the 44-kDa heparin-binding protein.". Genomics 25 (2): 492–500. doi:10.1016/0888-7543(95)80050-V. PMID 7789983.  
  • Medh JD, Fry GL, Bowen SL, et al. (1995). "The 39-kDa receptor-associated protein modulates lipoprotein catabolism by binding to LDL receptors.". J. Biol. Chem. 270 (2): 536–40. doi:10.1074/jbc.270.2.536. PMID 7822276.  
  • Korenberg JR, Argraves KM, Chen XN, et al. (1994). "Chromosomal localization of human genes for the LDL receptor family member glycoprotein 330 (LRP2) and its associated protein RAP (LRPAP1).". Genomics 22 (1): 88–93. doi:10.1006/geno.1994.1348. PMID 7959795.  
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  
  • Willnow TE, Rohlmann A, Horton J, et al. (1996). "RAP, a specialized chaperone, prevents ligand-induced ER retention and degradation of LDL receptor-related endocytic receptors.". Embo J. 15 (11): 2632–9. PMID 8654360.  
  • Jacobsen L, Madsen P, Moestrup SK, et al. (1997). "Molecular characterization of a novel human hybrid-type receptor that binds the alpha2-macroglobulin receptor-associated protein.". J. Biol. Chem. 271 (49): 31379–83. doi:10.1074/jbc.271.49.31379. PMID 8940146.  
  • Bu G, Rennke S, Geuze HJ (1997). "ERD2 proteins mediate ER retention of the HNEL signal of LRP's receptor-associated protein (RAP).". J. Cell. Sci. 110 ( Pt 1): 65–73. PMID 9010785.  
  • Petersen CM, Nielsen MS, Nykjaer A, et al. (1997). "Molecular identification of a novel candidate sorting receptor purified from human brain by receptor-associated protein affinity chromatography.". J. Biol. Chem. 272 (6): 3599–605. doi:10.1074/jbc.272.6.3599. PMID 9013611.  
  • Nielsen PR, Ellgaard L, Etzerodt M, et al. (1997). "The solution structure of the N-terminal domain of alpha2-macroglobulin receptor-associated protein.". Proc. Natl. Acad. Sci. U.S.A. 94 (14): 7521–5. doi:10.1073/pnas.94.14.7521. PMID 9207124.  

External links

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