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(Redirected to Lymphoid enhancer-binding factor 1 article)

From Wikipedia, the free encyclopedia

Lymphoid enhancer-binding factor 1

PDB rendering based on 2lef.
Available structures
Symbols LEF1; DKFZp586H0919; TCF1ALPHA
External IDs OMIM153245 MGI96770 HomoloGene7813 GeneCards: LEF1 Gene
RNA expression pattern
PBB GE LEF1 221558 s at tn.png
PBB GE LEF1 210948 s at tn.png
PBB GE LEF1 221557 s at tn.png
More reference expression data
Species Human Mouse
Entrez 51176 16842
Ensembl ENSG00000138795 ENSMUSG00000027985
UniProt Q9UJU2 Q3TYB0
RefSeq (mRNA) NM_016269 NM_010703
RefSeq (protein) NP_057353 NP_034833
Location (UCSC) Chr 4:
109.19 - 109.31 Mb
Chr 3:
131.1 - 131.21 Mb
PubMed search [1] [2]

Lymphoid enhancer-binding factor 1 is a protein that in humans is encoded by the LEF1 gene.[1]

Lymphoid enhancer-binding factor-1 (LEF1) is a 48-kD nuclear protein that is expressed in pre-B and T cells. It binds to a functionally important site in the T-cell receptor-alpha (TCRA; MIM 186880) enhancer and confers maximal enhancer activity. LEF1 belongs to a family of regulatory proteins that share homology with high mobility group protein-1 (HMG1; MIM 163905).[supplied by OMIM][2]



Lymphoid enhancer-binding factor 1 has been shown to interact with Beta-catenin,[3][4][5][6] PIAS4,[7] ALX4,[8] EP300,[9] Mothers against decapentaplegic homolog 3,[6] Microphthalmia-associated transcription factor[10] and Mothers against decapentaplegic homolog 2.[6]


  1. ^ Milatovich A, Travis A, Grosschedl R, Francke U (Mar 1992). "Gene for lymphoid enhancer-binding factor 1 (LEF1) mapped to human chromosome 4 (q23-q25) and mouse chromosome 3 near Egf". Genomics 11 (4): 1040–8. PMID 1783375.  
  2. ^ "Entrez Gene: LEF1 lymphoid enhancer-binding factor 1".  
  3. ^ Edlund, Sofia; Lee So Young, Grimsby Susanne, Zhang Shouthing, Aspenström Pontus, Heldin Carl-Henrik, Landström Maréne (Feb. 2005). "Interaction between Smad7 and beta-catenin: importance for transforming growth factor beta-induced apoptosis". Mol. Cell. Biol. (United States) 25 (4): 1475–88. doi:10.1128/MCB.25.4.1475-1488.2005. ISSN 0270-7306. PMID 15684397.  
  4. ^ Grueneberg, Dorre A; Pablo Lourdes, Hu Kang-Quan, August Paul, Weng Zhigang, Papkoff Jacqueline (Jun. 2003). "A functional screen in human cells identifies UBF2 as an RNA polymerase II transcription factor that enhances the beta-catenin signaling pathway". Mol. Cell. Biol. (United States) 23 (11): 3936–50. ISSN 0270-7306. PMID 12748295.  
  5. ^ Behrens, J; von Kries J P, Kühl M, Bruhn L, Wedlich D, Grosschedl R, Birchmeier W (Aug. 1996). "Functional interaction of beta-catenin with the transcription factor LEF-1". Nature (ENGLAND) 382 (6592): 638–42. doi:10.1038/382638a0. ISSN 0028-0836. PMID 8757136.  
  6. ^ a b c Labbé, E; Letamendia A, Attisano L (Jul. 2000). "Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (15): 8358–63. doi:10.1073/pnas.150152697. ISSN 0027-8424. PMID 10890911.  
  7. ^ Sachdev, S; Bruhn L, Sieber H, Pichler A, Melchior F, Grosschedl R (Dec. 2001). "PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies". Genes Dev. (United States) 15 (23): 3088–103. ISSN 0890-9369. PMID 11731472.  
  8. ^ Boras, Kata; Hamel Paul A (Jan. 2002). "Alx4 binding to LEF-1 regulates N-CAM promoter activity". J. Biol. Chem. (United States) 277 (2): 1120–7. doi:10.1074/jbc.M109912200. ISSN 0021-9258. PMID 11696550.  
  9. ^ Hecht, Andreas; Stemmler Marc P (Feb. 2003). "Identification of a promoter-specific transcriptional activation domain at the C terminus of the Wnt effector protein T-cell factor 4". J. Biol. Chem. (United States) 278 (6): 3776–85. doi:10.1074/jbc.M210081200. ISSN 0021-9258. PMID 12446687.  
  10. ^ Yasumoto, Ken-ichi; Takeda Kazuhisa, Saito Hideo, Watanabe Ken-ichi, Takahashi Kazuhiro, Shibahara Shigeki (Jun. 2002). "Microphthalmia-associated transcription factor interacts with LEF-1, a mediator of Wnt signaling". EMBO J. (England) 21 (11): 2703–14. doi:10.1093/emboj/21.11.2703. ISSN 0261-4189. PMID 12032083.  

Further reading

  • Waterman ML (2004). "Lymphoid enhancer factor/T cell factor expression in colorectal cancer.". Cancer Metastasis Rev. 23 (1-2): 41–52. doi:10.1023/A:1025858928620. PMID 15000148.  
  • Skokowa J, Welte K (2007). "LEF-1 is a decisive transcription factor in neutrophil granulopoiesis.". Ann. N. Y. Acad. Sci. 1106: 143–51. doi:10.1196/annals.1392.012. PMID 17360796.  
  • Travis A, Amsterdam A, Belanger C, Grosschedl R (1991). "LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected]". Genes Dev. 5 (5): 880–94. doi:10.1101/gad.5.5.880. PMID 1827423.  
  • van de Wetering M, Oosterwegel M, Dooijes D, Clevers H (1991). "Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box.". Embo J. 10 (1): 123–32. PMID 1989880.  
  • Waterman ML, Fischer WH, Jones KA (1991). "A thymus-specific member of the HMG protein family regulates the human T cell receptor C alpha enhancer.". Genes Dev. 5 (4): 656–69. doi:10.1101/gad.5.4.656. PMID 2010090.  
  • Zhou P, Byrne C, Jacobs J, Fuchs E (1995). "Lymphoid enhancer factor 1 directs hair follicle patterning and epithelial cell fate.". Genes Dev. 9 (6): 700–13. doi:10.1101/gad.9.6.700. PMID 7537238.  
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  
  • Prieve MG, Guttridge KL, Munguia JE, Waterman ML (1996). "The nuclear localization signal of lymphoid enhancer factor-1 is recognized by two differentially expressed Srp1-nuclear localization sequence receptor proteins.". J. Biol. Chem. 271 (13): 7654–8. doi:10.1074/jbc.271.13.7654. PMID 8631802.  
  • Behrens J, von Kries JP, Kühl M, et al. (1996). "Functional interaction of beta-catenin with the transcription factor LEF-1.". Nature 382 (6592): 638–42. doi:10.1038/382638a0. PMID 8757136.  
  • Bagga R, Emerson BM (1997). "An HMG I/Y-containing repressor complex and supercoiled DNA topology are critical for long-range enhancer-dependent transcription in vitro.". Genes Dev. 11 (5): 629–39. doi:10.1101/gad.11.5.629. PMID 9119227.  
  • Bruhn L, Munnerlyn A, Grosschedl R (1997). "ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function.". Genes Dev. 11 (5): 640–53. doi:10.1101/gad.11.5.640. PMID 9119228.  
  • Brannon M, Gomperts M, Sumoy L, et al. (1997). "A beta-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus.". Genes Dev. 11 (18): 2359–70. doi:10.1101/gad.11.18.2359. PMID 9308964.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  
  • Korinek V, Barker N, Willert K, et al. (1998). "Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse.". Mol. Cell. Biol. 18 (3): 1248–56. PMID 9488439.  
  • Prieve MG, Guttridge KL, Munguia J, Waterman ML (1998). "Differential importin-alpha recognition and nuclear transport by nuclear localization signals within the high-mobility-group DNA binding domains of lymphoid enhancer factor 1 and T-cell factor 1.". Mol. Cell. Biol. 18 (8): 4819–32. PMID 9671491.  
  • Levanon D, Goldstein RE, Bernstein Y, et al. (1998). "Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors.". Proc. Natl. Acad. Sci. U.S.A. 95 (20): 11590–5. doi:10.1073/pnas.95.20.11590. PMID 9751710.  
  • Hovanes K, Li TW, Waterman ML (2000). "The human LEF-1 gene contains a promoter preferentially active in lymphocytes and encodes multiple isoforms derived from alternative splicing.". Nucleic Acids Res. 28 (9): 1994–2003. doi:10.1093/nar/28.9.1994. PMID 10756202.  
  • Labbé E, Letamendia A, Attisano L (2000). "Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways.". Proc. Natl. Acad. Sci. U.S.A. 97 (15): 8358–63. doi:10.1073/pnas.150152697. PMID 10890911.  
  • Brantjes H, Roose J, van De Wetering M, Clevers H (2001). "All Tcf HMG box transcription factors interact with Groucho-related co-repressors.". Nucleic Acids Res. 29 (7): 1410–9. doi:10.1093/nar/29.7.1410. PMID 11266540.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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