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LIM homeobox 1
Symbols LHX1; LIM-1; LIM1; MGC126723; MGC138141
External IDs OMIM601999 MGI99783 HomoloGene4068 GeneCards: LHX1 Gene
RNA expression pattern
PBB GE LHX1 206230 at tn.png
More reference expression data
Species Human Mouse
Entrez 3975 16869
Ensembl ENSG00000132130 ENSMUSG00000018698
UniProt P48742 Q3URX6
RefSeq (mRNA) NM_005568 NM_008498
RefSeq (protein) NP_005559 NP_032524
Location (UCSC) Chr 17:
32.37 - 32.37 Mb
Chr 11:
84.33 - 84.34 Mb
PubMed search [1] [2]

LIM homeobox 1, also known as LHX1, is a gene.[1]

This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and be involved in control of differentiation and development of neural and lymphoid cells. A similar protein in mice is an essential regulator of the vertebrate head organizer.[1]


Further reading

  • Shawlot W, Behringer RR (1995). "Requirement for Lim1 in head-organizer function.". Nature 374 (6521): 425–30. doi:10.1038/374425a0. PMID 7700351.  
  • Bozzi F, Bertuzzi S, Strina D, et al. (1997). "The exon-intron structure of human LHX1 gene.". Biochem. Biophys. Res. Commun. 229 (2): 494–7. doi:10.1006/bbrc.1996.1832. PMID 8954926.  
  • Dong WF, Heng HH, Lowsky R, et al. (1997). "Cloning, expression, and chromosomal localization to 11p12-13 of a human LIM/HOMEOBOX gene, hLim-1.". DNA Cell Biol. 16 (6): 671–8. PMID 9212161.  
  • Jurata LW, Pfaff SL, Gill GN (1998). "The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors.". J. Biol. Chem. 273 (6): 3152–7. doi:10.1074/jbc.273.6.3152. PMID 9452425.  
  • Ostendorff HP, Peirano RI, Peters MA, et al. (2002). "Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors.". Nature 416 (6876): 99–103. doi:10.1038/416099a. PMID 11882901.  
  • Phillips JC (2003). "Assignment of LHX1 to human chromosome bands 17q11.2→q12 by use of radiation hybrid mapping and somatic cell hybridization.". Cytogenet. Genome Res. 97 (1-2): 140D. doi:10.1159/000064048. PMID 12438757.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Zody MC, Garber M, Adams DJ, et al. (2006). "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.". Nature 440 (7087): 1045–9. doi:10.1038/nature04689. PMID 16625196.  


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