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LIM homeobox 1
Identifiers
Symbols LHX1; LIM-1; LIM1; MGC126723; MGC138141
External IDs OMIM601999 MGI99783 HomoloGene4068 GeneCards: LHX1 Gene
RNA expression pattern
PBB GE LHX1 206230 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3975 16869
Ensembl ENSG00000132130 ENSMUSG00000018698
UniProt P48742 Q3URX6
RefSeq (mRNA) NM_005568 NM_008498
RefSeq (protein) NP_005559 NP_032524
Location (UCSC) Chr 17:
32.37 - 32.37 Mb
Chr 11:
84.33 - 84.34 Mb
PubMed search [1] [2]

LIM homeobox 1, also known as LHX1, is a gene.[1]

This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and be involved in control of differentiation and development of neural and lymphoid cells. A similar protein in mice is an essential regulator of the vertebrate head organizer.[1]

References

Further reading

  • Shawlot W, Behringer RR (1995). "Requirement for Lim1 in head-organizer function.". Nature 374 (6521): 425–30. doi:10.1038/374425a0. PMID 7700351.  
  • Bozzi F, Bertuzzi S, Strina D, et al. (1997). "The exon-intron structure of human LHX1 gene.". Biochem. Biophys. Res. Commun. 229 (2): 494–7. doi:10.1006/bbrc.1996.1832. PMID 8954926.  
  • Dong WF, Heng HH, Lowsky R, et al. (1997). "Cloning, expression, and chromosomal localization to 11p12-13 of a human LIM/HOMEOBOX gene, hLim-1.". DNA Cell Biol. 16 (6): 671–8. PMID 9212161.  
  • Jurata LW, Pfaff SL, Gill GN (1998). "The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors.". J. Biol. Chem. 273 (6): 3152–7. doi:10.1074/jbc.273.6.3152. PMID 9452425.  
  • Ostendorff HP, Peirano RI, Peters MA, et al. (2002). "Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors.". Nature 416 (6876): 99–103. doi:10.1038/416099a. PMID 11882901.  
  • Phillips JC (2003). "Assignment of LHX1 to human chromosome bands 17q11.2→q12 by use of radiation hybrid mapping and somatic cell hybridization.". Cytogenet. Genome Res. 97 (1-2): 140D. doi:10.1159/000064048. PMID 12438757.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Zody MC, Garber M, Adams DJ, et al. (2006). "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.". Nature 440 (7087): 1045–9. doi:10.1038/nature04689. PMID 16625196.  
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