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LIM homeobox 2

PDB rendering based on 2dmq.
Available structures
Symbols LHX2; LH2; MGC138390; hLhx2
External IDs OMIM603759 MGI96785 HomoloGene55848 GeneCards: LHX2 Gene
RNA expression pattern
PBB GE LHX2 206140 at tn.png
PBB GE LHX2 211219 s at tn.png
More reference expression data
Species Human Mouse
Entrez 9355 16870
Ensembl ENSG00000106689 ENSMUSG00000000247
UniProt P50458 Q543C6
RefSeq (mRNA) NM_004789 XM_972881
RefSeq (protein) NP_004780 XP_977975
Location (UCSC) Chr 9:
125.81 - 125.84 Mb
Chr 2:
38.17 - 38.19 Mb
PubMed search [1] [2]

LIM/homeobox protein Lhx2 is a protein that in humans is encoded by the LHX2 gene.[1][2][3]

This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator. The protein can recapitulate or rescue phenotypes in Drosophila caused by a related protein, suggesting conservation of function during evolution.[3]


LHX2 has been shown to interact with CITED2.[4]


  1. ^ Wu HK, Heng HH, Siderovski DP, Dong WF, Okuno Y, Shi XM, Tsui LC, Minden MD (Jul 1996). "Identification of a human LIM-Hox gene, hLH-2, aberrantly expressed in chronic myelogenous leukaemia and located on 9q33-34.1". Oncogene 12 (6): 1205–12. PMID 8649822.  
  2. ^ Rincon-Limas DE, Lu CH, Canal I, Calleja M, Rodriguez-Esteban C, Izpisua-Belmonte JC, Botas J (Apr 1999). "Conservation of the expression and function of apterous orthologs in Drosophila and mammals". Proc Natl Acad Sci U S A 96 (5): 2165–70. PMID 10051612.  
  3. ^ a b "Entrez Gene: LHX2 LIM homeobox 2".  
  4. ^ Glenn, D J; Maurer R A (Dec. 1999). "MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression". J. Biol. Chem. (UNITED STATES) 274 (51): 36159–67. ISSN 0021-9258. PMID 10593900.  

Further reading

  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Glenn DJ, Maurer RA (2000). "MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression.". J. Biol. Chem. 274 (51): 36159–67. doi:10.1074/jbc.274.51.36159. PMID 10593900.  
  • Bach I, Rodriguez-Esteban C, Carrière C, et al. (1999). "RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex.". Nat. Genet. 22 (4): 394–9. doi:10.1038/11970. PMID 10431247.  
  • Bendall AJ, Rincón-Limas DE, Botas J, Abate-Shen C (1998). "Protein complex formation between Msx1 and Lhx2 homeoproteins is incompatible with DNA binding activity.". Differentiation 63 (3): 151–7. doi:10.1046/j.1432-0436.1998.6330151.x. PMID 9697309.  


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