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LIM homeobox 6
Symbols LHX6; LHX6.1; MGC119542; MGC119544; MGC119545
External IDs OMIM608215 MGI1306803 HomoloGene7401 GeneCards: LHX6 Gene
RNA expression pattern
PBB GE LHX6 219884 at tn.png
More reference expression data
Species Human Mouse
Entrez 26468 16874
Ensembl ENSG00000106852 ENSMUSG00000026890
UniProt Q9UPM6 O88706
RefSeq (mRNA) NM_014368 NM_008500
RefSeq (protein) NP_055183 NP_032526
Location (UCSC) Chr 9:
124 - 124.03 Mb
Chr 2:
35.91 - 35.93 Mb
PubMed search [1] [2]

LIM/homeobox protein Lhx6 is a protein that in humans is encoded by the LHX6 gene.[1][2]

This gene encodes a member of a large protein family that contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and may be involved in the control of differentiation and development of neural and lymphoid cells. Two alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined.[2]


  1. ^ Kimura N, Ueno M, Nakashima K, Taga T (Oct 1999). "A brain region-specific gene product Lhx6.1 interacts with Ldb1 through tandem LIM-domains". J Biochem 126 (1): 180-7. PMID 10393337.  
  2. ^ a b "Entrez Gene: LHX6 LIM homeobox 6".  

Further reading

  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMID 11076863.  
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMID 15164053.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.  
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.  
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.  
  • Estécio MR, Youssef EM, Rahal P, et al. (2006). "LHX6 is a sensitive methylation marker in head and neck carcinomas.". Oncogene 25 (36): 5018–26. doi:10.1038/sj.onc.1209509. PMID 16732332.  


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