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Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2

PDB rendering based on 2dyp.
Available structures
2dyp, 2gw5
Identifiers
Symbols LILRB2; CD85D; ILT4; LIR-2; LIR2; MIR-10; MIR10
External IDs OMIM604815 HomoloGene81741 GeneCards: LILRB2 Gene
Orthologs
Species Human Mouse
Entrez 10288 n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) NM_001080978 n/a
RefSeq (protein) NP_001074447 n/a
Location (UCSC) n/a n/a
PubMed search [1] n/a

Leukocyte immunoglobulin-like receptor subfamily B member 2 is a protein that in humans is encoded by the LILRB2 gene.[1][2][3]

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.[3]

Contents

Interactions

LILRB2 has been shown to interact with PTPN6.[4][5]

See also

References

  1. ^ Cella M, Dohring C, Samaridis J, Dessing M, Brockhaus M, Lanzavecchia A, Colonna M (Jun 1997). "A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing". J Exp Med 185 (10): 1743–51. PMID 9151699.  
  2. ^ Samaridis J, Colonna M (Apr 1997). "Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways". Eur J Immunol 27 (3): 660–5. PMID 9079806.  
  3. ^ a b "Entrez Gene: LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10288.  
  4. ^ Fanger, N A; Cosman D, Peterson L, Braddy S C, Maliszewski C R, Borges L (Nov. 1998). "The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes". Eur. J. Immunol. (GERMANY) 28 (11): 3423–34. ISSN 0014-2980. PMID 9842885.  
  5. ^ Colonna, M; Samaridis J, Cella M, Angman L, Allen R L, O'Callaghan C A, Dunbar R, Ogg G S, Cerundolo V, Rolink A (Apr. 1998). "Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules". J. Immunol. (UNITED STATES) 160 (7): 3096–100. ISSN 0022-1767. PMID 9531263.  

Further reading

  • Suciu-Foca N, Cortesini R (2007). "Central role of ILT3 in the T suppressor cell cascade.". Cell. Immunol. 248 (1): 59–67. doi:10.1016/j.cellimm.2007.01.013. PMID 17923119.  
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  
  • Wagtmann N, Rojo S, Eichler E, et al. (1997). "A new human gene complex encoding the killer cell inhibitory receptors and related monocyte/macrophage receptors.". Curr. Biol. 7 (8): 615–8. doi:10.1016/S0960-9822(06)00263-6. PMID 9259559.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  
  • Colonna M, Navarro F, Bellón T, et al. (1997). "A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells.". J. Exp. Med. 186 (11): 1809–18. doi:10.1084/jem.186.11.1809. PMID 9382880.  
  • Colonna M, Samaridis J, Cella M, et al. (1998). "Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules.". J. Immunol. 160 (7): 3096–100. PMID 9531263.  
  • Borges L, Hsu ML, Fanger N, et al. (1998). "A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules.". J. Immunol. 159 (11): 5192–6. PMID 9548455.  
  • Fanger NA, Cosman D, Peterson L, et al. (1998). "The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes.". Eur. J. Immunol. 28 (11): 3423–34. doi:10.1002/(SICI)1521-4141(199811)28:11<3423::AID-IMMU3423>3.0.CO;2-2. PMID 9842885.  
  • Allan DS, Colonna M, Lanier LL, et al. (1999). "Tetrameric complexes of human histocompatibility leukocyte antigen (HLA)-G bind to peripheral blood myelomonocytic cells.". J. Exp. Med. 189 (7): 1149–56. doi:10.1084/jem.189.7.1149. PMID 10190906.  
  • Lepin EJ, Bastin JM, Allan DS, et al. (2001). "Functional characterization of HLA-F and binding of HLA-F tetramers to ILT2 and ILT4 receptors.". Eur. J. Immunol. 30 (12): 3552–61. doi:10.1002/1521-4141(200012)30:12<3552::AID-IMMU3552>3.0.CO;2-L. PMID 11169396.  
  • Young NT, Canavez F, Uhrberg M, et al. (2001). "Conserved organization of the ILT/LIR gene family within the polymorphic human leukocyte receptor complex.". Immunogenetics 53 (4): 270–8. doi:10.1007/s002510100332. PMID 11491530.  
  • Chang CC, Ciubotariu R, Manavalan JS, et al. (2002). "Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4.". Nat. Immunol. 3 (3): 237–43. doi:10.1038/ni760. PMID 11875462.  
  • Willcox BE, Thomas LM, Chapman TL, et al. (2003). "Crystal structure of LIR-2 (ILT4) at 1.8 A: differences from LIR-1 (ILT2) in regions implicated in the binding of the Human Cytomegalovirus class I MHC homolog UL18.". BMC Struct. Biol. 2: 6. doi:10.1186/1472-6807-2-6. PMID 12390682.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Shiroishi M, Tsumoto K, Amano K, et al. (2003). "Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G.". Proc. Natl. Acad. Sci. U.S.A. 100 (15): 8856–61. doi:10.1073/pnas.1431057100. PMID 12853576.  
  • Nakajima H, Asai A, Okada A, et al. (2004). "Transcriptional regulation of ILT family receptors.". J. Immunol. 171 (12): 6611–20. PMID 14662864.  
  • Papanikolaou NA, Vasilescu ER, Suciu-Foca N (2005). "Novel single nucleotide polymorphisms in the human immune inhibitory immunoglobulin-like T cell receptor type 4.". Hum. Immunol. 65 (7): 700–5. doi:10.1016/j.humimm.2004.04.003. PMID 15301858.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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