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LIM homeobox transcription factor 1, alpha
Identifiers
Symbols LMX1A; LMX-1; LMX1; LMX1.1; MGC87616
External IDs OMIM600298 MGI1888519 HomoloGene24921 GeneCards: LMX1A Gene
Orthologs
Species Human Mouse
Entrez 4009 110648
Ensembl ENSG00000162761 ENSMUSG00000026686
UniProt Q8TE12 Q543W2
RefSeq (mRNA) NM_001033507 NM_033652
RefSeq (protein) NP_001028679 NP_387501
Location (UCSC) Chr 1:
163.44 - 163.59 Mb
Chr 1:
169.53 - 169.69 Mb
PubMed search [1] [2]

LIM homeobox transcription factor 1, alpha, also known as LMX1A, is a protein which in humans is encoded by the LMX1A gene.[1][2]

Contents

Function

Insulin is produced exclusively by the beta cells in the islets of Langerhans in the pancreas. The level and beta-cell specificity of insulin gene expression are regulated by a set of nuclear genes that bind to specific sequences within the promoter of the insulin gene INS and interact with RNA polymerase to activate or repress transcription. LMX1 is a LIM homeobox transcription factor that binds an A/T-rich sequence in the insulin promoter and stimulates transcription of insulin.[1]

Interactions

LMX1A has been shown to interact with TCF3[3] and LHX3.[4]

References

  1. ^ a b "Entrez Gene: LMX1A LIM homeobox transcription factor 1, alpha". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4009.  
  2. ^ German MS, Wang J, Fernald AA, Espinosa R, Le Beau MM, Bell GI (November 1994). "Localization of the genes encoding two transcription factors, LMX1 and CDX3, regulating insulin gene expression to human chromosomes 1 and 13". Genomics 24 (2): 403–4. doi:10.1006/geno.1994.1639. PMID 7698771.  
  3. ^ Johnson, J D; Zhang W, Rudnick A, Rutter W J, German M S (Jul. 1997). "Transcriptional synergy between LIM-homeodomain proteins and basic helix-loop-helix proteins: the LIM2 domain determines specificity". Mol. Cell. Biol. (UNITED STATES) 17 (7): 3488–96. ISSN 0270-7306. PMID 9199284.  
  4. ^ Jurata, L W; Pfaff S L, Gill G N (Feb. 1998). "The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors". J. Biol. Chem. (UNITED STATES) 273 (6): 3152–7. ISSN 0021-9258. PMID 9452425.  

Further reading

  • German MS, Wang J, Chadwick RB, Rutter WJ (1992). "Synergistic activation of the insulin gene by a LIM-homeo domain protein and a basic helix-loop-helix protein: building a functional insulin minienhancer complex.". Genes Dev. 6 (11): 2165–76. doi:10.1101/gad.6.11.2165. PMID 1358758.  
  • German MS, Wang J, Fernald AA, et al. (1995). "Localization of the genes encoding two transcription factors, LMX1 and CDX3, regulating insulin gene expression to human chromosomes 1 and 13.". Genomics 24 (2): 403–4. doi:10.1006/geno.1994.1639. PMID 7698771.  
  • Jurata LW, Gill GN (1997). "Functional analysis of the nuclear LIM domain interactor NLI.". Mol. Cell. Biol. 17 (10): 5688–98. PMID 9315627.  
  • Iannotti CA, Inoue H, Bernal E, et al. (1998). "Identification of a human LMX1 (LMX1.1)-related gene, LMX1.2: tissue-specific expression and linkage mapping on chromosome 9.". Genomics 46 (3): 520–4. doi:10.1006/geno.1997.5075. PMID 9441763.  
  • Jurata LW, Pfaff SL, Gill GN (1998). "The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors.". J. Biol. Chem. 273 (6): 3152–7. doi:10.1074/jbc.273.6.3152. PMID 9452425.  
  • Thameem F, Wolford JK, Wang J, et al. (2002). "Cloning, expression and genomic structure of human LMX1A, and variant screening in Pima Indians.". Gene 290 (1-2): 217–25. doi:10.1016/S0378-1119(02)00582-6. PMID 12062816.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Millen KJ, Millonig JH, Hatten ME (2004). "Roof plate and dorsal spinal cord dl1 interneuron development in the dreher mutant mouse.". Dev. Biol. 270 (2): 382–92. doi:10.1016/j.ydbio.2004.03.008. PMID 15183721.  
  • Hassel S, Eichner A, Yakymovych M, et al. (2004). "Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry.". Proteomics 4 (5): 1346–58. doi:10.1002/pmic.200300770. PMID 15188402.  
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.  
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