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lysophosphatidic acid receptor 4
Symbols LPAR4; GPR23; LPA4; P2RY9; P2Y5-LIKE; P2Y9
External IDs OMIM300086 MGI1925384 HomoloGene3871 IUPHAR: GeneCards: LPAR4 Gene
RNA expression pattern
PBB GE GPR23 206960 at tn.png
More reference expression data
Species Human Mouse
Entrez 2846 78134
Ensembl ENSG00000147145 ENSMUSG00000049929
UniProt Q99677 Q80UD5
RefSeq (mRNA) NM_005296 NM_175271
RefSeq (protein) NP_005287 NP_780480
Location (UCSC) Chr X:
77.9 - 77.9 Mb
Chr X:
103.12 - 103.14 Mb
PubMed search [1] [2]

Lysophosphatidic acid receptor 4 also known as LPA4 is a protein that in humans is encoded by the LPAR4 gene.[1][2][3] LPA4 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).[4]

See also


  1. ^ "Entrez Gene: GPR23 G protein-coupled receptor 23".  
  2. ^ Janssens R, Boeynaems JM, Godart M, Communi D (July 1997). "Cloning of a human heptahelical receptor closely related to the P2Y5 receptor". Biochem. Biophys. Res. Commun. 236 (1): 106–12. doi:10.1006/bbrc.1997.6895. PMID 9223435.  
  3. ^ O'Dowd BF, Nguyen T, Jung BP, Marchese A, Cheng R, Heng HH, Kolakowski LF, Lynch KR, George SR (March 1997). "Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes". Gene 187 (1): 75–81. PMID 9073069.  
  4. ^ Choi JW, Herr DR, Noguchi K, Yung YC, Lee C-W, Mutoh T, Lin M-E, Teo ST, Park KE, Mosley AN, Chun J (January 2010). "LPA Receptors: Subtypes and Biological Actions". Annual Review of Pharmacology and Toxicology 50 (1): 157–186. doi:10.1146/annurev.pharmtox.010909.105753.  

Further reading

  • Adrian K, Bernhard MK, Breitinger HG, Ogilvie A (2000). "Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells.". Biochim. Biophys. Acta 1492 (1): 127–38. PMID 11004484.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Noguchi K, Ishii S, Shimizu T (2003). "Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family.". J. Biol. Chem. 278 (28): 25600–6. doi:10.1074/jbc.M302648200. PMID 12724320.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMID 15772651.  
  • Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMID 16335952.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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