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lysophosphatidic acid receptor 4
Identifiers
Symbols LPAR4; GPR23; LPA4; P2RY9; P2Y5-LIKE; P2Y9
External IDs OMIM300086 MGI1925384 HomoloGene3871 IUPHAR: GeneCards: LPAR4 Gene
RNA expression pattern
PBB GE GPR23 206960 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2846 78134
Ensembl ENSG00000147145 ENSMUSG00000049929
UniProt Q99677 Q80UD5
RefSeq (mRNA) NM_005296 NM_175271
RefSeq (protein) NP_005287 NP_780480
Location (UCSC) Chr X:
77.9 - 77.9 Mb
Chr X:
103.12 - 103.14 Mb
PubMed search [1] [2]

Lysophosphatidic acid receptor 4 also known as LPA4 is a protein that in humans is encoded by the LPAR4 gene.[1][2][3] LPA4 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).[4]

See also

References

  1. ^ "Entrez Gene: GPR23 G protein-coupled receptor 23". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2846.  
  2. ^ Janssens R, Boeynaems JM, Godart M, Communi D (July 1997). "Cloning of a human heptahelical receptor closely related to the P2Y5 receptor". Biochem. Biophys. Res. Commun. 236 (1): 106–12. doi:10.1006/bbrc.1997.6895. PMID 9223435.  
  3. ^ O'Dowd BF, Nguyen T, Jung BP, Marchese A, Cheng R, Heng HH, Kolakowski LF, Lynch KR, George SR (March 1997). "Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes". Gene 187 (1): 75–81. PMID 9073069.  
  4. ^ Choi JW, Herr DR, Noguchi K, Yung YC, Lee C-W, Mutoh T, Lin M-E, Teo ST, Park KE, Mosley AN, Chun J (January 2010). "LPA Receptors: Subtypes and Biological Actions". Annual Review of Pharmacology and Toxicology 50 (1): 157–186. doi:10.1146/annurev.pharmtox.010909.105753. http://arjournals.annualreviews.org/doi/abs/10.1146/annurev.pharmtox.010909.105753.  

Further reading

  • Adrian K, Bernhard MK, Breitinger HG, Ogilvie A (2000). "Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells.". Biochim. Biophys. Acta 1492 (1): 127–38. PMID 11004484.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Noguchi K, Ishii S, Shimizu T (2003). "Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family.". J. Biol. Chem. 278 (28): 25600–6. doi:10.1074/jbc.M302648200. PMID 12724320.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMID 15772651.  
  • Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMID 16335952.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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