The Full Wiki

More info on LPAR5

LPAR5: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

edit
lysophosphatidic acid receptor 5
Identifiers
Symbols LPAR5; GPR92 ; GPR93; KPG_010; LPA5
External IDs OMIM606926 MGI2685918 HomoloGene10696 IUPHAR: GeneCards: LPAR5 Gene
Orthologs
Species Human Mouse
Entrez 57121 381810
Ensembl ENSG00000184574 ENSMUSG00000067714
UniProt Q9H1C0 n/a
RefSeq (mRNA) NM_020400 XM_355812
RefSeq (protein) NP_065133 XP_355812
Location (UCSC) Chr 12:
6.6 - 6.62 Mb
Chr 6:
125.03 - 125.05 Mb
PubMed search [1] [2]

Lysophosphatidic acid receptor 5 also known as LPA5 is a protein that in humans is encoded by the LPAR5 gene.[1][2][3][4][5] LPA5 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).[6]

See also

References

  1. ^ "Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23". Nat Genet 26 (3): 345-8. Dec 2000. doi:10.1038/81664. PMID 11062477.  
  2. ^ Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF (Sep 2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene 275 (1): 83-91. PMID 11574155.  
  3. ^ Lee CW, Rivera R, Gardell S, Dubin AE, Chun J (Aug 2006). "GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5". J Biol Chem 281 (33): 23589-97. doi:10.1074/jbc.M603670200. PMID 16774927.  
  4. ^ Kotarsky K, Boketoft A, Bristulf J, Nilsson NE, Norberg A, Hansson S, Owman C, Sillard R, Leeb-Lundberg LM, Olde B (Jul 2006). "Lysophosphatidic acid binds to and activates GPR92, a G protein-coupled receptor highly expressed in gastrointestinal lymphocytes". J Pharmacol Exp Ther 318 (2): 619-28. doi:10.1124/jpet.105.098848. PMID 16651401.  
  5. ^ "Entrez Gene: GPR92 G protein-coupled receptor 92". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57121.  
  6. ^ Choi JW, Herr DR, Noguchi K, Yung YC, Lee C-W, Mutoh T, Lin M-E, Teo ST, Park KE, Mosley AN, Chun J (January 2010). "LPA Receptors: Subtypes and Biological Actions". Annual Review of Pharmacology and Toxicology 50 (1): 157–186. doi:10.1146/annurev.pharmtox.010909.105753. http://arjournals.annualreviews.org/doi/abs/10.1146/annurev.pharmtox.010909.105753.  

Further reading

  • Takeda S, Kadowaki S, Haga T, et al. (2002). "Identification of G protein-coupled receptor genes from the human genome sequence.". FEBS Lett. 520 (1-3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message