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Latrophilin 2
Symbols LPHN2; CIRL2; CL2; LEC1; LPHH1
External IDs OMIM607018 MGI2139714 HomoloGene22712 IUPHAR: LPHN2 GeneCards: LPHN2 Gene
RNA expression pattern
PBB GE LPHN2 206953 s at tn.png
More reference expression data
Species Human Mouse
Entrez 23266 99633
Ensembl ENSG00000117114 ENSMUSG00000028184
UniProt O95490 Q0P6A0
RefSeq (mRNA) NM_012302 XM_888040
RefSeq (protein) NP_036434 XP_893133
Location (UCSC) Chr 1:
81.54 - 82.23 Mb
Chr 3:
148.75 - 148.79 Mb
PubMed search [1] [2]

Latrophilin-2 is a protein that in humans is encoded by the LPHN2 gene.[1][2]

This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. While several transcript variants have been described, the biological validity of only one has been determined.[2]

See also


  1. ^ White GR, Varley JM, Heighway J (Jul 2000). "Genomic structure and expression profile of LPHH1, a 7TM gene variably expressed in breast cancer cell lines". Biochim Biophys Acta 1491 (1-3): 75-92. PMID 10760572.  
  2. ^ a b "Entrez Gene: LPHN2 latrophilin 2".  

Further reading

  • Südhof TC (2001). "alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins.". Annu. Rev. Neurosci. 24: 933–62. doi:10.1146/annurev.neuro.24.1.933. PMID 11520923.  
  • Ushkaryov YA, Volynski KE, Ashton AC (2004). "The multiple actions of black widow spider toxins and their selective use in neurosecretion studies.". Toxicon 43 (5): 527–42. doi:10.1016/j.toxicon.2004.02.008. PMID 15066411.  
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.  
  • Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.  
  • White GR, Varley JM, Heighway J (1999). "Isolation and characterization of a human homologue of the latrophilin gene from a region of 1p31.1 implicated in breast cancer.". Oncogene 17 (26): 3513–9. doi:10.1038/sj.onc.1202487. PMID 10030676.  
  • Kreienkamp HJ, Zitzer H, Gundelfinger ED, et al. (2000). "The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins.". J. Biol. Chem. 275 (42): 32387–90. doi:10.1074/jbc.C000490200. PMID 10964907.  
  • Bjarnadóttir TK, Fredriksson R, Höglund PJ, et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.". Genomics 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.  
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.  
  • Clark TA, Schweitzer AC, Chen TX, et al. (2007). "Discovery of tissue-specific exons using comprehensive human exon microarrays.". Genome Biol. 8 (4): R64. doi:10.1186/gb-2007-8-4-r64. PMID 17456239.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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