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From Wikipedia, the free encyclopedia

Lymphocyte antigen 9
Symbols LY9; CD229; SLAMF3; hly9; mLY9
External IDs OMIM600684 MGI96885 HomoloGene1759 GeneCards: LY9 Gene
RNA expression pattern
PBB GE LY9 210370 s at tn.png
PBB GE LY9 215967 s at tn.png
More reference expression data
Species Human Mouse
Entrez 4063 17085
Ensembl ENSG00000122224 ENSMUSG00000004707
UniProt Q9HBG7 Q4VBG4
RefSeq (mRNA) NM_001033667 NM_008534
RefSeq (protein) NP_001028839 NP_032560
Location (UCSC) Chr 1:
159.03 - 159.06 Mb
Chr 1:
173.43 - 173.44 Mb
PubMed search [1] [2]

T-lymphocyte surface antigen Ly-9 is a protein that in humans is encoded by the LY9 gene.[1][2][3] LY9 has also recently been designated CD229 (cluster of differentiation 229).



LY9 has been shown to interact with SH2D1A.[4][5]


  1. ^ Sandrin MS, Henning MM, Lo MF, Baker E, Sutherland GR, McKenzie IF (Feb 1996). "Isolation and characterization of cDNA clones for Humly9: the human homologue of mouse Ly9". Immunogenetics 43 (1-2): 13–9. PMID 8537117.  
  2. ^ Kingsmore SF, Souryal CA, Watson ML, Patel DD, Seldin MF (Aug 1995). "Physical and genetic linkage of the genes encoding Ly-9 and CD48 on mouse and human chromosomes 1". Immunogenetics 42 (1): 59–62. PMID 7797269.  
  3. ^ "Entrez Gene: LY9 lymphocyte antigen 9".  
  4. ^ Sayós, J; Martín M, Chen A, Simarro M, Howie D, Morra M, Engel P, Terhorst C (Jun. 2001). "Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP". Blood (United States) 97 (12): 3867–74. ISSN 0006-4971. PMID 11389028.  
  5. ^ Morra, M; Simarro-Grande M, Martin M, Chen A S, Lanyi A, Silander O, Calpe S, Davis J, Pawson T, Eck M J, Sumegi J, Engel P, Li S C, Terhorst C (Sep. 2001). "Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients". J. Biol. Chem. (United States) 276 (39): 36809–16. doi:10.1074/jbc.M101305200. ISSN 0021-9258. PMID 11477068.  

Further reading

  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.  
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174.  
  • Tovar V, de la Fuente MA, Pizcueta P, et al. (2000). "Gene structure of the mouse leukocyte cell surface molecule Ly9.". Immunogenetics 51 (10): 788–93. PMID 10970093.  
  • de la Fuente MA, Tovar V, Villamor N, et al. (2001). "Molecular characterization and expression of a novel human leukocyte cell-surface marker homologous to mouse Ly-9.". Blood 97 (11): 3513–20. PMID 11369645.  
  • Sayós J, Martín M, Chen A, et al. (2001). "Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP.". Blood 97 (12): 3867–74. PMID 11389028.  
  • Morra M, Simarro-Grande M, Martin M, et al. (2001). "Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients.". J. Biol. Chem. 276 (39): 36809–16. doi:10.1074/jbc.M101305200. PMID 11477068.  
  • Morra M, Lu J, Poy F, et al. (2001). "Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells.". EMBO J. 20 (21): 5840–52. doi:10.1093/emboj/20.21.5840. PMID 11689425.  
  • Tovar V, del Valle J, Zapater N, et al. (2002). "Mouse novel Ly9: a new member of the expanding CD150 (SLAM) family of leukocyte cell-surface receptors.". Immunogenetics 54 (6): 394–402. doi:10.1007/s00251-002-0483-3. PMID 12242590.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Del Valle JM, Engel P, Martín M (2003). "The cell surface expression of SAP-binding receptor CD229 is regulated via its interaction with clathrin-associated adaptor complex 2 (AP-2).". J. Biol. Chem. 278 (19): 17430–7. doi:10.1074/jbc.M301569200. PMID 12621057.  
  • Martín M, Del Valle JM, Saborit I, Engel P (2005). "Identification of Grb2 as a novel binding partner of the signaling lymphocytic activation molecule-associated protein binding receptor CD229.". J. Immunol. 174 (10): 5977–86. PMID 15879090.  
  • Romero X, Zapater N, Calvo M, et al. (2005). "CD229 (Ly9) lymphocyte cell surface receptor interacts homophilically through its N-terminal domain and relocalizes to the immunological synapse.". J. Immunol. 174 (11): 7033–42. PMID 15905546.  
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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