The Full Wiki

LY9: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

edit
Lymphocyte antigen 9
Identifiers
Symbols LY9; CD229; SLAMF3; hly9; mLY9
External IDs OMIM600684 MGI96885 HomoloGene1759 GeneCards: LY9 Gene
RNA expression pattern
PBB GE LY9 210370 s at tn.png
PBB GE LY9 215967 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4063 17085
Ensembl ENSG00000122224 ENSMUSG00000004707
UniProt Q9HBG7 Q4VBG4
RefSeq (mRNA) NM_001033667 NM_008534
RefSeq (protein) NP_001028839 NP_032560
Location (UCSC) Chr 1:
159.03 - 159.06 Mb
Chr 1:
173.43 - 173.44 Mb
PubMed search [1] [2]

T-lymphocyte surface antigen Ly-9 is a protein that in humans is encoded by the LY9 gene.[1][2][3] LY9 has also recently been designated CD229 (cluster of differentiation 229).

Contents

Interactions

LY9 has been shown to interact with SH2D1A.[4][5]

References

  1. ^ Sandrin MS, Henning MM, Lo MF, Baker E, Sutherland GR, McKenzie IF (Feb 1996). "Isolation and characterization of cDNA clones for Humly9: the human homologue of mouse Ly9". Immunogenetics 43 (1-2): 13–9. PMID 8537117.  
  2. ^ Kingsmore SF, Souryal CA, Watson ML, Patel DD, Seldin MF (Aug 1995). "Physical and genetic linkage of the genes encoding Ly-9 and CD48 on mouse and human chromosomes 1". Immunogenetics 42 (1): 59–62. PMID 7797269.  
  3. ^ "Entrez Gene: LY9 lymphocyte antigen 9". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4063.  
  4. ^ Sayós, J; Martín M, Chen A, Simarro M, Howie D, Morra M, Engel P, Terhorst C (Jun. 2001). "Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP". Blood (United States) 97 (12): 3867–74. ISSN 0006-4971. PMID 11389028.  
  5. ^ Morra, M; Simarro-Grande M, Martin M, Chen A S, Lanyi A, Silander O, Calpe S, Davis J, Pawson T, Eck M J, Sumegi J, Engel P, Li S C, Terhorst C (Sep. 2001). "Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients". J. Biol. Chem. (United States) 276 (39): 36809–16. doi:10.1074/jbc.M101305200. ISSN 0021-9258. PMID 11477068.  

Further reading

  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.  
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174.  
  • Tovar V, de la Fuente MA, Pizcueta P, et al. (2000). "Gene structure of the mouse leukocyte cell surface molecule Ly9.". Immunogenetics 51 (10): 788–93. PMID 10970093.  
  • de la Fuente MA, Tovar V, Villamor N, et al. (2001). "Molecular characterization and expression of a novel human leukocyte cell-surface marker homologous to mouse Ly-9.". Blood 97 (11): 3513–20. PMID 11369645.  
  • Sayós J, Martín M, Chen A, et al. (2001). "Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP.". Blood 97 (12): 3867–74. PMID 11389028.  
  • Morra M, Simarro-Grande M, Martin M, et al. (2001). "Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients.". J. Biol. Chem. 276 (39): 36809–16. doi:10.1074/jbc.M101305200. PMID 11477068.  
  • Morra M, Lu J, Poy F, et al. (2001). "Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells.". EMBO J. 20 (21): 5840–52. doi:10.1093/emboj/20.21.5840. PMID 11689425.  
  • Tovar V, del Valle J, Zapater N, et al. (2002). "Mouse novel Ly9: a new member of the expanding CD150 (SLAM) family of leukocyte cell-surface receptors.". Immunogenetics 54 (6): 394–402. doi:10.1007/s00251-002-0483-3. PMID 12242590.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Del Valle JM, Engel P, Martín M (2003). "The cell surface expression of SAP-binding receptor CD229 is regulated via its interaction with clathrin-associated adaptor complex 2 (AP-2).". J. Biol. Chem. 278 (19): 17430–7. doi:10.1074/jbc.M301569200. PMID 12621057.  
  • Martín M, Del Valle JM, Saborit I, Engel P (2005). "Identification of Grb2 as a novel binding partner of the signaling lymphocytic activation molecule-associated protein binding receptor CD229.". J. Immunol. 174 (10): 5977–86. PMID 15879090.  
  • Romero X, Zapater N, Calvo M, et al. (2005). "CD229 (Ly9) lymphocyte cell surface receptor interacts homophilically through its N-terminal domain and relocalizes to the immunological synapse.". J. Immunol. 174 (11): 7033–42. PMID 15905546.  
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message