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LYL1: Wikis


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Lymphoblastic leukemia derived sequence 1
Symbols LYL1;
External IDs OMIM151440 MGI96891 HomoloGene4078 GeneCards: LYL1 Gene
RNA expression pattern
PBB GE LYL1 210044 s at tn.png
More reference expression data
Species Human Mouse
Entrez 4066 17095
Ensembl ENSG00000104903 ENSMUSG00000034041
UniProt P12980 Q4FK84
RefSeq (mRNA) NM_005583 NM_008535
RefSeq (protein) NP_005574 NP_032561
Location (UCSC) Chr 19:
13.07 - 13.07 Mb
Chr 8:
87.59 - 87.59 Mb
PubMed search [1] [2]

Protein lyl-1 is a protein that in humans is encoded by the LYL1 gene.[1][2]



LYL1 has been shown to interact with TCF3[3] and NFKB1.[4]


  1. ^ Mellentin JD, Smith SD, Cleary ML (Aug 1989). "lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif". Cell 58 (1): 77–83. PMID 2752424.  
  2. ^ "Entrez Gene: LYL1 lymphoblastic leukemia derived sequence 1".  
  3. ^ Miyamoto, A; Cui X, Naumovski L, Cleary M L (May. 1996). "Helix-loop-helix proteins LYL1 and E2a form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cells". Mol. Cell. Biol. (UNITED STATES) 16 (5): 2394–401. ISSN 0270-7306. PMID 8628307.  
  4. ^ Ferrier, R; Nougarede R, Doucet S, Kahn-Perles B, Imbert J, Mathieu-Mahul D (Jan. 1999). "Physical interaction of the bHLH LYL1 protein and NF-kappaB1 p105". Oncogene (ENGLAND) 18 (4): 995–1005. doi:10.1038/sj.onc.1202374. ISSN 0950-9232. PMID 10023675.  

Further reading

  • Xia Y, Brown L, Yang CY, et al. (1992). "TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia.". Proc. Natl. Acad. Sci. U.S.A. 88 (24): 11416–20. doi:10.1073/pnas.88.24.11416. PMID 1763056.  
  • Kuo SS, Mellentin JD, Copeland NG, et al. (1991). "Structure, chromosome mapping, and expression of the mouse Lyl-1 gene.". Oncogene 6 (6): 961–8. PMID 2067848.  
  • Saltman DL, Mellentin JD, Smith SD, Cleary ML (1991). "Mapping of translocation breakpoints on the short arm of chromosome 19 in acute leukemias by in situ hybridization.". Genes Chromosomes Cancer 2 (4): 259–65. doi:10.1002/gcc.2870020402. PMID 2268576.  
  • Wadman I, Li J, Bash RO, et al. (1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia.". Embo J. 13 (20): 4831–9. PMID 7957052.  
  • Trask B, Fertitta A, Christensen M, et al. (1993). "Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers.". Genomics 15 (1): 133–45. doi:10.1006/geno.1993.1021. PMID 8432525.  
  • Miyamoto A, Cui X, Naumovski L, Cleary ML (1996). "Helix-loop-helix proteins LYL1 and E2a form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cells.". Mol. Cell. Biol. 16 (5): 2394–401. PMID 8628307.  
  • Mahajan MA, Park ST, Sun XH (1996). "Association of a novel GTP binding protein, DRG, with TAL oncogenic proteins.". Oncogene 12 (11): 2343–50. PMID 8649774.  
  • Ferrier R, Nougarede R, Doucet S, et al. (1999). "Physical interaction of the bHLH LYL1 protein and NF-kappaB1 p105.". Oncogene 18 (4): 995–1005. doi:10.1038/sj.onc.1202374. PMID 10023675.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Meng YS, Khoury H, Dick JE, Minden MD (2005). "Oncogenic potential of the transcription factor LYL1 in acute myeloblastic leukemia.". Leukemia 19 (11): 1941–7. doi:10.1038/sj.leu.2403836. PMID 16094422.  

External links



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