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Lanosterol 14 alpha-demethylase: Wikis

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cytochrome P450, family 51, subfamily A, polypeptide 1
Identifiers
Symbol CYP51A1
Alt. symbols CYP51, P45014DM
Entrez 1595
HUGO 2649
OMIM 601637
RefSeq NM_000786
UniProt Q16850
Other data
EC number 1.14.13.70
Locus Chr. 7 q21.2-21.3

CYP51A1 (or lanosterol 14 alpha-demethylase, P45014DM) is a cytochrome P450 (family 51, subfamily A, polypeptide 1) which converts lanosterol to cholesterol.

It is a target for antifungal drugs, inhibiting the production of ergosterol. Over-expression of CYP51A1 can lead to resistance to these antifungals.[1]

See also

References

  1. ^ Vanden Bossche H, Dromer F, Improvisi I, Lozano-Chiu M, Rex JH, Sanglard D (1998). "Antifungal drug resistance in pathogenic fungi". Med. Mycol. 36 Suppl 1: 119–28. PMID 9988500.  

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