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Lansoprazole: Wikis


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Systematic (IUPAC) name
CAS number 103577-45-3
ATC code A02BC03
PubChem 3883
DrugBank APRD00077
ChemSpider 3746
Chemical data
Formula C16H14F3N3O2S 
Mol. mass 369.363 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability 80% or more
Protein binding 97%
Metabolism Hepatic (CYP3A4- and CYP2C19-mediated)
Half life 1–1.5 hours
Excretion Renal and fecal
Therapeutic considerations
Licence data

US FDA:link

Pregnancy cat. B3(AU) B(US)
Legal status OTC (US) Rx Only
Routes Oral, IV
 Yes check.svgY(what is this?)  (verify)

Lansoprazole (pronounced /lænˈsoʊprəzoʊl/, lan-SOE-pra-zole, INN) is a proton-pump inhibitor (PPI) which prevents the stomach from producing gastric acid. It is manufactured by a number of companies worldwide under several brand names (some brand names include: Prevacid, Helicid, Zoton, Inhibitol). It was first approved by the U.S. Food and Drug Administration (FDA) in 1995.[1]

Prevacid patent protection expired on November 10, 2009.[2][3] As a result, prescription Lansoprazole is now available in the form of a generic drug. As of November 12, 2009 (2009 -11-12) lansoprazole is available over-the-counter (OTC) in the U.S. in a 15 mg dose marketed by Novartis as Prevacid 24HR.[4][5][6]

Currently (November 25, 2009), prescription Lansoprazole and OTC Prevacid sell for about 50% and 25% of the cost of prescription Prevacid, respectively, in the U.S.



Lansoprazole is a proton-pump inhibitor (PPI) in the same pharmacologic class as omeprazole. Lansoprazole has been marketed for many years and is one of several PPIs available.[7] Lansoprazole is a racemate [1:1-mixture of the enantiomers dexlansoprazole (Kapidex) and levolansoprazole].[8] Dexlanprantazole is an enantiomerically pure active ingredient of a commercial drug as a result of the 'enantiomeric shift'.

Lansoprazole's plasma elimination half-life is not proportional to the duration of the drug's effects (i.e. gastric acid suppression). The mean plasma elimination half-life is 1.5 hours,[9] and the effects of the drug last for over 24 hours after it has been used for 1 day or more.[10]


Lansoprazole is indicated for:

Drug interactions

Side effects

Proton-pump inhibitors may be associated with a greater risk of hip fractures,[13] clostridium difficile-associated diarrhea.[14] Patients are frequently administered the drugs in intensive care as a protective measure against ulcers, but this use is also associated with a 30% increase in occurrence of pneumonia.[15]

Brand names

Prevacid 30 mg

The drug is sold under several brand names, including:[1]

  • Agopton (Germany)
  • Lansor (Turkey)
  • Digest (Indonesia)
  • Duogast (Syria)
  • Gastrolan (Indonesia)
  • Lanpro (India)
  • Lanzol (India)
  • Lanzul (Slovenia)
  • Lansoptol (Hungary)
  • Lansox (Italy)
  • Lansoloc (South Africa)
  • Lanton (Israel)
  • Lanzo (Sweden)
  • Lanzor (France)
  • Laprazol (Greece)
  • Lanciprol (Greece)
  • Limpidex (Italy)
  • Monolitum (Spain)
  • Ogast and OgastORO (France)
  • Ogastro (Mexico)
  • Prevacid (U.S. and Canada) Prevacid is a product of Takeda Pharmaceuticals.
  • Prevacid 24HR (U.S.)
  • pro-ulco (Spain)
  • Prosogan and Prosogan FD (Indonesia)
  • Refluxon (Hungary)
  • SOLOX (New Zealand)
  • Takepron (Japan)
  • Zolt (Finland)
  • Zoton (Italy, Ireland, Australia, UK)
  • ZOMEL (Ireland)

Lansoprazole is also available as a generic drug in the US, UK, Canada, Belgium, Finland,[16] France, Colombia, Italy, Sweden,[17] and Mexico.[citation needed]


  1. ^ a b Mosby's Drug Consult: Lansoprazole
  2. ^ Prevacid drug patents
  3. ^ Teva to release Prevacid version when patent expires
  4. ^ "Novartis launches Prevacid 24HR over-the-counter for full 24-hour frequent heartburn treatment" (PDF). Press release. November 12, 2009. Retrieved 2009-11-13. 
  5. ^ "Prevacid 24HR Patient Package Insert" (PDF). November 12, 2009. Retrieved 2009-11-13. 
  6. ^ "Novartis launches Prevacid 24HR over-the-counter for full 24-hour frequent heartburn treatment". Press release. November 12, 2009. Retrieved 2009-11-13. 
  7. ^
  8. ^
  9. ^ a b "Prevacid Pharmacology, Pharmacokinetics, Studies, Metabolism". 2007. Retrieved 2007-04-14. 
  10. ^ "Prevacid 24HR Fact Sheet" (PDF). November 12, 2009. Retrieved 2009-11-13. 
  11. ^ Antimicrob Agents Chemother. 1991 September; 35(9): 1765–1771. Effects of ranitidine and sucralfate on ketoconazole bioavailability. S C Piscitelli, T F Goss, J H Wilton, D T D'Andrea, H Goldstein, and J J Schentag [1]
  12. ^ Sterry W, Assaf C (2007). "Erythroderma". in Bolognia JL. Dermatology. St. Louis: Mosby. p. 154. ISBN 1-4160-2999-0. 
  13. ^ Yang YX, Lewis JD, Epstein S, Metz DC (December 2006). "Long-term proton pump inhibitor therapy and risk of hip fracture". JAMA 296 (24): 2947–53. doi:10.1001/jama.296.24.2947. PMID 17190895. 
  14. ^ "Proton pump inhibitors and Clostridium difficile". Bandolier. 2003. Retrieved 2007-07-13. 
  15. ^ Herzig SJ, Howell MD, Ngo LH, Marcantonio ER (May 2009). "Acid-suppressive medication use and the risk for hospital-acquired pneumonia". JAMA 301 (20): 2120–8. doi:10.1001/jama.2009.722. PMID 19470989. 
  16. ^ "Vastaavat tuotteet - hintavertailu" (in Finnish). 
  17. ^ ", accessed 2010-02-13" (in Swedish). 

External links

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