The Full Wiki

Lansoprazole: Wikis

  

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

Lansoprazole
Systematic (IUPAC) name
(RS)-2-([3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylsulfinyl)-1H-benzo[d]imidazole
Identifiers
CAS number 103577-45-3
ATC code A02BC03
PubChem 3883
DrugBank APRD00077
ChemSpider 3746
Chemical data
Formula C16H14F3N3O2S 
Mol. mass 369.363 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability 80% or more
Protein binding 97%
Metabolism Hepatic (CYP3A4- and CYP2C19-mediated)
Half life 1–1.5 hours
Excretion Renal and fecal
Therapeutic considerations
Licence data

US FDA:link

Pregnancy cat. B3(AU) B(US)
Legal status OTC (US) Rx Only
Routes Oral, IV
 Yes check.svgY(what is this?)  (verify)

Lansoprazole (pronounced /lænˈsoʊprəzoʊl/, lan-SOE-pra-zole, INN) is a proton-pump inhibitor (PPI) which prevents the stomach from producing gastric acid. It is manufactured by a number of companies worldwide under several brand names (some brand names include: Prevacid, Helicid, Zoton, Inhibitol). It was first approved by the U.S. Food and Drug Administration (FDA) in 1995.[1]

Prevacid patent protection expired on November 10, 2009.[2][3] As a result, prescription Lansoprazole is now available in the form of a generic drug. As of November 12, 2009 (2009 -11-12) lansoprazole is available over-the-counter (OTC) in the U.S. in a 15 mg dose marketed by Novartis as Prevacid 24HR.[4][5][6]

Currently (November 25, 2009), prescription Lansoprazole and OTC Prevacid sell for about 50% and 25% of the cost of prescription Prevacid, respectively, in the U.S.

Contents

Pharmacology

Lansoprazole is a proton-pump inhibitor (PPI) in the same pharmacologic class as omeprazole. Lansoprazole has been marketed for many years and is one of several PPIs available.[7] Lansoprazole is a racemate [1:1-mixture of the enantiomers dexlansoprazole (Kapidex) and levolansoprazole].[8] Dexlanprantazole is an enantiomerically pure active ingredient of a commercial drug as a result of the 'enantiomeric shift'.

Lansoprazole's plasma elimination half-life is not proportional to the duration of the drug's effects (i.e. gastric acid suppression). The mean plasma elimination half-life is 1.5 hours,[9] and the effects of the drug last for over 24 hours after it has been used for 1 day or more.[10]

Indications

Lansoprazole is indicated for:

Drug interactions

Side effects

Proton-pump inhibitors may be associated with a greater risk of hip fractures,[13] clostridium difficile-associated diarrhea.[14] Patients are frequently administered the drugs in intensive care as a protective measure against ulcers, but this use is also associated with a 30% increase in occurrence of pneumonia.[15]

Brand names

Prevacid 30 mg

The drug is sold under several brand names, including:[1]

  • Agopton (Germany)
  • Lansor (Turkey)
  • Digest (Indonesia)
  • Duogast (Syria)
  • Gastrolan (Indonesia)
  • Lanpro (India)
  • Lanzol (India)
  • Lanzul (Slovenia)
  • Lansoptol (Hungary)
  • Lansox (Italy)
  • Lansoloc (South Africa)
  • Lanton (Israel)
  • Lanzo (Sweden)
  • Lanzor (France)
  • Laprazol (Greece)
  • Lanciprol (Greece)
  • Limpidex (Italy)
  • Monolitum (Spain)
  • Ogast and OgastORO (France)
  • Ogastro (Mexico)
  • Prevacid (U.S. and Canada) Prevacid is a product of Takeda Pharmaceuticals.
  • Prevacid 24HR (U.S.)
  • pro-ulco (Spain)
  • Prosogan and Prosogan FD (Indonesia)
  • Refluxon (Hungary)
  • SOLOX (New Zealand)
  • Takepron (Japan)
  • Zolt (Finland)
  • Zoton (Italy, Ireland, Australia, UK)
  • ZOMEL (Ireland)

Lansoprazole is also available as a generic drug in the US, UK, Canada, Belgium, Finland,[16] France, Colombia, Italy, Sweden,[17] and Mexico.[citation needed]

References

  1. ^ a b Mosby's Drug Consult: Lansoprazole
  2. ^ Prevacid drug patents
  3. ^ Teva to release Prevacid version when patent expires
  4. ^ "Novartis launches Prevacid 24HR over-the-counter for full 24-hour frequent heartburn treatment" (PDF). Press release. November 12, 2009. http://www.prevacid24hr.com/pdfs/News%20media%20release%20-%20Prevacid24HR%20Launch%20-%20November%202009.pdf. Retrieved 2009-11-13. 
  5. ^ "Prevacid 24HR Patient Package Insert" (PDF). November 12, 2009. http://www.prevacid24hr.com/pdfs/PackageInsert.pdf. Retrieved 2009-11-13. 
  6. ^ "Novartis launches Prevacid 24HR over-the-counter for full 24-hour frequent heartburn treatment". Press release. November 12, 2009. http://www.novartis.com/newsroom/media-releases/en/2009/1354451.shtml. Retrieved 2009-11-13. 
  7. ^ http://www.patient.co.uk/showdoc/30002943/
  8. ^ http://www.mainecarepdl.org/index.pl/genpharmfiles/memos-and-mailings/pharmacy-benefit-update-summer-fall-2009.pdf
  9. ^ a b "Prevacid Pharmacology, Pharmacokinetics, Studies, Metabolism". RxList.com. 2007. http://www.rxlist.com/cgi/generic/lansop_cp.htm. Retrieved 2007-04-14. 
  10. ^ "Prevacid 24HR Fact Sheet" (PDF). November 12, 2009. http://www.prevacid24hr.com/pdfs/Prevacid24HR_Product_Fact_Sheet.pdf. Retrieved 2009-11-13. 
  11. ^ Antimicrob Agents Chemother. 1991 September; 35(9): 1765–1771. Effects of ranitidine and sucralfate on ketoconazole bioavailability. S C Piscitelli, T F Goss, J H Wilton, D T D'Andrea, H Goldstein, and J J Schentag [1]
  12. ^ Sterry W, Assaf C (2007). "Erythroderma". in Bolognia JL. Dermatology. St. Louis: Mosby. p. 154. ISBN 1-4160-2999-0. 
  13. ^ Yang YX, Lewis JD, Epstein S, Metz DC (December 2006). "Long-term proton pump inhibitor therapy and risk of hip fracture". JAMA 296 (24): 2947–53. doi:10.1001/jama.296.24.2947. PMID 17190895. 
  14. ^ "Proton pump inhibitors and Clostridium difficile". Bandolier. 2003. http://www.medicine.ox.ac.uk/bandolier/booth/Pharmacy/PPIcdiff.html. Retrieved 2007-07-13. 
  15. ^ Herzig SJ, Howell MD, Ngo LH, Marcantonio ER (May 2009). "Acid-suppressive medication use and the risk for hospital-acquired pneumonia". JAMA 301 (20): 2120–8. doi:10.1001/jama.2009.722. PMID 19470989. 
  16. ^ "Vastaavat tuotteet - hintavertailu" (in Finnish). http://www.terveyskirjasto.fi/terveysportti/geneerinen.substituutio?p_ryhma=0000130030. 
  17. ^ "FASS.se, accessed 2010-02-13" (in Swedish). http://www.fass.se/LIF/produktfakta/substance_products.jsp?substanceId=IDE4POFNUB4MJVERT1. 

External links








Got something to say? Make a comment.
Your name
Your email address
Message