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Lapachol[1][2]
Lapachol.png
IUPAC name
Identifiers
CAS number 84-79-7
PubChem 3884
SMILES
Properties
Molecular formula C15H14O3
Molar mass 242.27
Appearance Yellow crystals
Melting point

140 °C, 413 K, 284 °F

Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Lapachol is a natural organic compound isolated from the lapacho tree (Tabebuia avellandedae).[3] Chemically, it is a derivative of naphthoquinone, related to vitamin K.

Once studied as a possible treatment for some types of cancer, lapachol's potential is now considered low due to its toxic side effects.[4][5][6][7]

References

  1. ^ [1] Lapochol at R&D Chemicals.
  2. ^ [2] Lapochol at CromaDex.
  3. ^ Record, Samuel J. Lapachol. Tropical Woods (1925), 1 7-9.
  4. ^ Felício AC, Chang CV, Brandão MA, Peters VM, Guerra Mde O (2002). "Fetal growth in rats treated with lapachol". Contraception 66 (4): 289–93. doi:10.1016/S0010-7824(02)00356-6. PMID 12413627.  
  5. ^ Oral toxicology studies with lapachol. Morrison, Robert K.; Brown, Donald Emerson; Oleson, Jerome J.; Cooney, David A. Toxicology and Applied Pharmacology (1970), 17(1), 1-11.
  6. ^ Guerra Mde O, Mazoni AS, Brandão MA, Peters VM (2001). "Toxicology of Lapachol in rats: embryolethality". Brazilian journal of biology = Revista brasleira de biologia 61 (1): 171–4. PMID 11340475.  
  7. ^ de Cássia da Silveira E Sá R, de Oliveira Guerra M (2007). "Reproductive toxicity of lapachol in adult male Wistar rats submitted to short-term treatment". Phytotherapy research : PTR 21 (7): 658–62. doi:10.1002/ptr.2141. PMID 17421057.  

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