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Leptin receptor
Identifiers
Symbols LEPR; CD295; OBR
External IDs OMIM601007 MGI104993 HomoloGene1731 GeneCards: LEPR Gene
Orthologs
Species Human Mouse
Entrez 3953 16847
Ensembl n/a ENSMUSG00000057722
UniProt n/a P48356
RefSeq (mRNA) NM_001003679 NM_010704
RefSeq (protein) NP_001003679 NP_034834
Location (UCSC) n/a Chr 4:
101.22 - 101.31 Mb
PubMed search [1] [2]

Leptin receptor is a protein that in humans is encoded by the LEPR gene.[1][2] LEPR has also been designated as CD295 (cluster of differentiation 295).

Leptin (LEP; MIM 164160), an adipocyte-specific hormone that regulates adipose-tissue mass through hypothalamic effects on satiety and energy expenditure, acts through the leptin receptor (LEPR), a single-transmembrane-domain receptor of the cytokine receptor family.[supplied by OMIM][3]

The db/db mouse is a model of diabetes wherein leptin receptor activity is deficient because the mice are homozygous for a point mutation in the gene for the leptin receptor.[4]

Variations in the leptin receptor have been associated with obesity.[5] In db/db mice, induced swimming helped to overcome this condition by upregulating uncoupling proteins.[6]

References

  1. ^ Tartaglia LA, Dembski M, Weng X, Deng N, Culpepper J, Devos R, Richards GJ, Campfield LA, Clark FT, Deeds J, Muir C, Sanker S, Moriarty A, Moore KJ, Smutko JS, Mays GG, Wool EA, Monroe CA, Tepper RI (Feb 1996). "Identification and expression cloning of a leptin receptor, OB-R". Cell 83 (7): 1263-71. PMID 8548812.  
  2. ^ Winick JD, Stoffel M, Friedman JM (Feb 1997). "Identification of microsatellite markers linked to the human leptin receptor gene on chromosome 1". Genomics 36 (1): 221-2. doi:10.1006/geno.1996.0455. PMID 8812446.  
  3. ^ "Entrez Gene: LEPR leptin receptor". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3953.  
  4. ^ Sharma K, McCue P, Dunn SR. (June 2003). "Diabetic kidney disease in the db/db mouse". Am J Physiol Renal Physiol. 284 (6): F1138-44. doi:10.1152/ajprenal.00315.2002. PMID 12736165. http://ajprenal.physiology.org/cgi/content/full/284/6/F1138.  
  5. ^ Masuo K, Straznicky NE, Lambert GW, et al. (June 2008). "Leptin-receptor polymorphisms relate to obesity through blunted leptin-mediated sympathetic nerve activation in a Caucasian male population". Hypertens. Res. 31 (6): 1093–100. doi:10.1291/hypres.31.1093. PMID 18716356. http://dx.doi.org/10.1291/hypres.31.1093.  
  6. ^ Oh KS, Kim EY, Yoon M, Lee CM (June 2007). "Swim training improves leptin receptor deficiency-induced obesity and lipid disorder by activating uncoupling proteins". Exp. Mol. Med. 39 (3): 385–94. PMID 17603293. http://www.e-emm.org/search_read.htm?page=385&year=2007&vol=39.  

Further reading

  • Heshka JT, Jones PJ (2001). "A role for dietary fat in leptin receptor, OB-Rb, function.". Life Sci. 69 (9): 987–1003. doi:10.1016/S0024-3205(01)01201-2. PMID 11508653.  
  • Chen H, Charlat O, Tartaglia LA, et al. (1996). "Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice.". Cell 84 (3): 491–5. doi:10.1016/S0092-8674(00)81294-5. PMID 8608603.  
  • Cioffi JA, Shafer AW, Zupancic TJ, et al. (1996). "Novel B219/OB receptor isoforms: possible role of leptin in hematopoiesis and reproduction.". Nat. Med. 2 (5): 585–9. doi:10.1038/nm0596-585. PMID 8616721.  
  • Considine RV, Considine EL, Williams CJ, et al. (1996). "The hypothalamic leptin receptor in humans: identification of incidental sequence polymorphisms and absence of the db/db mouse and fa/fa rat mutations.". Diabetes 45 (7): 992–4. doi:10.2337/diabetes.45.7.992. PMID 8666155.  
  • Chung WK, Power-Kehoe L, Chua M, Leibel RL (1996). "Mapping of the OB receptor to 1p in a region of nonconserved gene order from mouse and rat to human.". Genome Res. 6 (5): 431–8. doi:10.1101/gr.6.5.431. PMID 8743992.  
  • Bennett BD, Solar GP, Yuan JQ, et al. (1997). "A role for leptin and its cognate receptor in hematopoiesis.". Curr. Biol. 6 (9): 1170–80. doi:10.1016/S0960-9822(02)70684-2. PMID 8805376.  
  • Luoh SM, Di Marco F, Levin N, et al. (1997). "Cloning and characterization of a human leptin receptor using a biologically active leptin immunoadhesin.". J. Mol. Endocrinol. 18 (1): 77–85. doi:10.1677/jme.0.0180077. PMID 9061609.  
  • Echwald SM, Sørensen TD, Sørensen TI, et al. (1997). "Amino acid variants in the human leptin receptor: lack of association to juvenile onset obesity.". Biochem. Biophys. Res. Commun. 233 (1): 248–52. doi:10.1006/bbrc.1997.6430. PMID 9144432.  
  • Thompson DB, Ravussin E, Bennett PH, Bogardus C (1997). "Structure and sequence variation at the human leptin receptor gene in lean and obese Pima Indians.". Hum. Mol. Genet. 6 (5): 675–9. doi:10.1093/hmg/6.5.675. PMID 9158141.  
  • Gotoda T, Manning BS, Goldstone AP, et al. (1997). "Leptin receptor gene variation and obesity: lack of association in a white British male population.". Hum. Mol. Genet. 6 (6): 869–76. doi:10.1093/hmg/6.6.869. PMID 9175732.  
  • Bailleul B, Akerblom I, Strosberg AD (1997). "The leptin receptor promoter controls expression of a second distinct protein.". Nucleic Acids Res. 25 (14): 2752–8. doi:10.1093/nar/25.14.2752. PMID 9207021.  
  • Chung WK, Power-Kehoe L, Chua M, et al. (1997). "Exonic and intronic sequence variation in the human leptin receptor gene (LEPR).". Diabetes 46 (9): 1509–11. PMID 9287054.  
  • Bjørbaek C, Uotani S, da Silva B, Flier JS (1998). "Divergent signaling capacities of the long and short isoforms of the leptin receptor.". J. Biol. Chem. 272 (51): 32686–95. doi:10.1074/jbc.272.51.32686. PMID 9405487.  
  • Clément K, Vaisse C, Lahlou N, et al. (1998). "A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction.". Nature 392 (6674): 398–401. doi:10.1038/32911. PMID 9537324.  
  • Carpenter LR, Farruggella TJ, Symes A, et al. (1998). "Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor.". Proc. Natl. Acad. Sci. U.S.A. 95 (11): 6061–6. doi:10.1073/pnas.95.11.6061. PMID 9600917.  
  • Kielar D, Clark JS, Ciechanowicz A, et al. (1998). "Leptin receptor isoforms expressed in human adipose tissue.". Metab. Clin. Exp. 47 (7): 844–7. PMID 9667233.  
  • Haniu M, Arakawa T, Bures EJ, et al. (1998). "Human leptin receptor. Determination of disulfide structure and N-glycosylation sites of the extracellular domain.". J. Biol. Chem. 273 (44): 28691–9. doi:10.1074/jbc.273.44.28691. PMID 9786864.  
  • Haft CR, de la Luz Sierra M, Barr VA, et al. (1998). "Identification of a family of sorting nexin molecules and characterization of their association with receptors.". Mol. Cell. Biol. 18 (12): 7278–87. PMID 9819414.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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