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From Wikipedia, the free encyclopedia

The Leser-Trélat sign is the explosive onset of multiple seborrheic keratoses (many pigmented skin lesions),[1]:638 [2] often with an inflammatory base. This can be an ominous sign of internal malignancy as part of a paraneoplastic syndrome. In addition to the development of new lesions, preexisting ones frequently increase in size and become symptomatic.

It is named for Edmund Leser and Ulysse Trélat.[3]

Although most associated neoplasms are gastrointestinal adenocarcinomas (stomach, liver, colorectal and pancreas), breast, lung, and urinary tract cancers, as well as lymphoid malignancies are associated with this impressive rash. It is likely that various cytokines and other growth factors produced by the neoplasm are responsible for the abrupt appearance of the seborrheic keratoses. In some cases, paraneoplastic acanthosis nigricans accompanies the sign of Leser-Trélat.


  1. ^ Odom, Richard B.; Davidsohn, Israel; James, William D.; Henry, John Bernard; Berger, Timothy G.; Clinical diagnosis by laboratory methods; Dirk M. Elston (2006). Andrews' diseases of the skin: clinical dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.  
  2. ^ "eMedicine - Sign of Leser-Trelat : Article by Robert A Schwartz".  
  3. ^ synd/3211 at Who Named It?


  • Gregory B, Ho VC (February 1992). "Cutaneous manifestations of gastrointestinal disorders. Part I". J. Am. Acad. Dermatol. 26 (2 Pt 1): 153–66. PMID 1552046.  
  • Yaniv R, Servadio Y, Feinstein A, Trau H (March 1994). "The sign of Leser-Trélat associated with transitional cell carcinoma of the urinary-bladder--a case report and short review". Clin. Exp. Dermatol. 19 (2): 142–5. PMID 8050144.  


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