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A leukoerythroblastic picture on blood film can be the bone marrow response to any irritation including marrow infiltration [causing immature red cells]. Marrow infiltrative disorders include myelomas, malignancy, myelofibrosis, etc. It can also occur as a response to severe critical illness, such as trauma, septicaemia, massive haemolysis, or severe megaloblastic anaemia. Leukoerthyroblastic change refers to the presence of nucleated red blood cells and primitive white blood cells.

Seen in bone marrow failure, myelofibrosis and extramedullary haemopoiesis.