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Leukotriene B4 receptor
Symbols LTB4R; BLT1; BLTR; CMKRL1; GPR16; LTB4R1; LTBR1; P2RY7; P2Y7
External IDs OMIM601531 MGI1309472 HomoloGene22477 IUPHAR: BLT1 GeneCards: LTB4R Gene
Species Human Mouse
Entrez 1241 16995
Ensembl Ensembl:ENSG00000213903 ENSMUSG00000046908
UniProt Q15722 Q3U2P2
RefSeq (mRNA) NM_181657 NM_008519
RefSeq (protein) NP_858043 NP_032545
Location (UCSC) Chr 14:
24.78 - 24.79 Mb
Chr 14:
54.72 - 54.72 Mb
PubMed search [1] [2]

Leukotriene B4 receptor 1 is a protein that in humans is encoded by the LTB4R gene.[1][2][3]


See also


  1. ^ Owman C, Nilsson C, Lolait SJ (Feb 1997). "Cloning of cDNA encoding a putative chemoattractant receptor". Genomics 37 (2): 187-94. doi:10.1006/geno.1996.0541. PMID 8921391.  
  2. ^ Akbar GK, Dasari VR, Webb TE, Ayyanathan K, Pillarisetti K, Sandhu AK, Athwal RS, Daniel JL, Ashby B, Barnard EA, Kunapuli SP (Sep 1996). "Molecular cloning of a novel P2 purinoceptor from human erythroleukemia cells". J Biol Chem 271 (31): 18363-7. PMID 8702478.  
  3. ^ "Entrez Gene: LTB4R leukotriene B4 receptor".  

Further reading

  • Raport CJ, Schweickart VL, Chantry D, et al. (1996). "New members of the chemokine receptor gene family.". J. Leukoc. Biol. 59 (1): 18–23. PMID 8558062.  
  • Tager AM, Luster AD (2004). "BLT1 and BLT2: the leukotriene B(4) receptors.". Prostaglandins Leukot. Essent. Fatty Acids 69 (2-3): 123–34. doi:10.1016/S0952-3278(03)00073-5. PMID 12895595.  
  • Miyahara N, Miyahara S, Takeda K, Gelfand EW (2006). "Role of the LTB4/BLT1 pathway in allergen-induced airway hyperresponsiveness and inflammation.". Allergology international : official journal of the Japanese Society of Allergology 55 (2): 91–7. doi:10.2332/allergolint.55.91. PMID 17075244.  
  • Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.  
  • Yokomizo T, Izumi T, Chang K, et al. (1997). "A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis.". Nature 387 (6633): 620–4. doi:10.1038/42506. PMID 9177352.  
  • Maier R, Glatz A, Mosbacher J, Bilbe G (1997). "Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues.". Biochem. Biophys. Res. Commun. 237 (2): 297–302. doi:10.1006/bbrc.1997.7135. PMID 9268704.  
  • Gaudreau R, Le Gouill C, Métaoui S, et al. (1998). "Signalling through the leukotriene B4 receptor involves both alphai and alpha16, but not alphaq or alpha11 G-protein subunits.". Biochem. J. 335 ( Pt 1): 15–8. PMID 9742207.  
  • Kato K, Yokomizo T, Izumi T, Shimizu T (2000). "Cell-specific transcriptional regulation of human leukotriene B(4) receptor gene.". J. Exp. Med. 192 (3): 413–20. doi:10.1084/jem.192.3.413. PMID 10934229.  
  • Yokomizo T, Kato K, Terawaki K, et al. (2000). "A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders.". J. Exp. Med. 192 (3): 421–32. doi:10.1084/jem.192.3.421. PMID 10934230.  
  • Stankova J, Turcotte S, Harris J, Rola-Pleszczynski M (2002). "Modulation of leukotriene B4 receptor-1 expression by dexamethasone: potential mechanism for enhanced neutrophil survival.". J. Immunol. 168 (7): 3570–6. PMID 11907121.  
  • Gaudreau R, Le Gouill C, Venne MH, et al. (2002). "Threonine 308 within a putative casein kinase 2 site of the cytoplasmic tail of leukotriene B(4) receptor (BLT1) is crucial for ligand-induced, G-protein-coupled receptor-specific kinase 6-mediated desensitization.". J. Biol. Chem. 277 (35): 31567–76. doi:10.1074/jbc.M202723200. PMID 12077128.  
  • Hennig R, Ding XZ, Tong WG, et al. (2002). "5-Lipoxygenase and leukotriene B(4) receptor are expressed in human pancreatic cancers but not in pancreatic ducts in normal tissue.". Am. J. Pathol. 161 (2): 421–8. PMID 12163367.  
  • Ito N, Yokomizo T, Sasaki T, et al. (2003). "Requirement of phosphatidylinositol 3-kinase activation and calcium influx for leukotriene B4-induced enzyme release.". J. Biol. Chem. 277 (47): 44898–904. doi:10.1074/jbc.M208051200. PMID 12244116.  
  • Tong WG, Ding XZ, Hennig R, et al. (2003). "Leukotriene B4 receptor antagonist LY293111 inhibits proliferation and induces apoptosis in human pancreatic cancer cells.". Clin. Cancer Res. 8 (10): 3232–42. PMID 12374694.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Yokomizo T, Noiri E, Izumi T, Shimizu T (2003). "In vivo chemotaxis using CHO cells expressing human leukotriene B4 receptor.". Adv. Exp. Med. Biol. 507: 357–61. PMID 12664610.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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