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Leukotriene B4 receptor 2
Symbols LTB4R2; BLT2; BLTR2; JULF2; KPG_004; NOP9
External IDs OMIM605773 MGI1888501 HomoloGene10519 IUPHAR: BLT2 GeneCards: LTB4R2 Gene
Species Human Mouse
Entrez 56413 57260
Ensembl n/a ENSMUSG00000040432
UniProt Q9NPC1 Q3KP98
RefSeq (mRNA) NM_019839 NM_020490
RefSeq (protein) NP_062813 NP_065236
Location (UCSC) n/a Chr 14:
54.72 - 54.72 Mb
PubMed search [1] [2]

Leukotriene B4 receptor 2 is a protein that in humans is encoded by the LTB4R2 gene.[1][2][3]

This is a low-affinity receptor for leukotrienes, especially leukotriene B4. It mediates chemotaxis of granulocytes and macrophages.


See also


  1. ^ Wang S, Gustafson E, Pang L, Qiao X, Behan J, Maguire M, Bayne M, Laz T (Jan 2001). "A novel hepatointestinal leukotriene B4 receptor. Cloning and functional characterization". J Biol Chem 275 (52): 40686-94. doi:10.1074/jbc.M004512200. PMID 11006272.  
  2. ^ Kato K, Yokomizo T, Izumi T, Shimizu T (Sep 2000). "Cell-specific transcriptional regulation of human leukotriene B(4) receptor gene". J Exp Med 192 (3): 413-20. PMID 10934229.  
  3. ^ "Entrez Gene: LTB4R2 leukotriene B4 receptor 2".  

External links

Further reading

  • Tager AM, Luster AD (2004). "BLT1 and BLT2: the leukotriene B(4) receptors.". Prostaglandins Leukot. Essent. Fatty Acids 69 (2-3): 123–34. doi:10.1016/S0952-3278(03)00073-5. PMID 12895595.  
  • Kamohara M, Takasaki J, Matsumoto M, et al. (2000). "Molecular cloning and characterization of another leukotriene B4 receptor.". J. Biol. Chem. 275 (35): 27000–4. doi:10.1074/jbc.C000382200. PMID 10889186.  
  • Tryselius Y, Nilsson NE, Kotarsky K, et al. (2000). "Cloning and characterization of cDNA encoding a novel human leukotriene B(4) receptor.". Biochem. Biophys. Res. Commun. 274 (2): 377–82. doi:10.1006/bbrc.2000.3152. PMID 10913346.  
  • Nilsson NE, Tryselius Y, Owman C (2000). "Genomic organization of the leukotriene B(4) receptor locus of human chromosome 14.". Biochem. Biophys. Res. Commun. 274 (2): 383–8. doi:10.1006/bbrc.2000.3153. PMID 10913347.  
  • Yokomizo T, Kato K, Terawaki K, et al. (2000). "A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders.". J. Exp. Med. 192 (3): 421–32. doi:10.1084/jem.192.3.421. PMID 10934230.  
  • Takeda S, Kadowaki S, Haga T, et al. (2002). "Identification of G protein-coupled receptor genes from the human genome sequence.". FEBS Lett. 520 (1-3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Hashimoto A, Endo H, Hayashi I, et al. (2003). "Differential expression of leukotriene B4 receptor subtypes (BLT1 and BLT2) in human synovial tissues and synovial fluid leukocytes of patients with rheumatoid arthritis.". J. Rheumatol. 30 (8): 1712–8. PMID 12913925.  
  • Yoo MH, Song H, Woo CH, et al. (2005). "Role of the BLT2, a leukotriene B4 receptor, in Ras transformation.". Oncogene 23 (57): 9259–68. doi:10.1038/sj.onc.1208151. PMID 15489890.  
  • Qiu H, Johansson AS, Sjöström M, et al. (2006). "Differential induction of BLT receptor expression on human endothelial cells by lipopolysaccharide, cytokines, and leukotriene B4.". Proc. Natl. Acad. Sci. U.S.A. 103 (18): 6913–8. doi:10.1073/pnas.0602208103. PMID 16624877.  
  • Lundeen KA, Sun B, Karlsson L, Fourie AM (2006). "Leukotriene B4 receptors BLT1 and BLT2: expression and function in human and murine mast cells.". J. Immunol. 177 (5): 3439–47. PMID 16920986.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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