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Lidoflazine: Wikis

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Lidoflazine
Systematic (IUPAC) name
2-[4-[4,4-bis(4-fluorophenyl)butyl]piperazin-1-yl]-N-(2,6-dimethylphenyl)acetamide
Identifiers
CAS number 3416-26-0
ATC code C08EX01
PubChem 3926
Chemical data
Formula C 30H35F2N3O 
Mol. mass 491.615
Physical data
Melt. point 159–161 °C (318–322 °F)
Solubility in water Almost insoluble in water(<0.01%); Very soluble in chloroform(>50%); mg/mL (20 °C)
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Lidoflazine is a piperazine calcium channel blocker. It is a coronary vasodilator with some antiarrhythmic action.[1] Lidoflazine was discovered at Janssen Pharmaceutica in 1964.

Physical properties

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Solubility at room temperature

Extracted from [2]

Solvent 0.01

N

0.1

N

 % pH  % pH
Hydrochloric Acid 0.4 3.0 0.7 1.9
Tartaric Acid 0.3 3.1 1.0 2.5
Citric Acid 0.3 3.1 0.5 2.5
Lactic Acid 0.2 3.4 0.7 2.9
Acetic Acid 0.1 3.5 0.4 3.8

References

  1. ^ Schaper, W.K.A.; Xhonneux, R.; Jageneau, A.H.M.; Janssen, P.A.J. (1966). "The cardiovascular pharmacology of lidoflazine, a long-acting coronary vasodilator". Journal of Pharmacology and Experimental Therapeutics 152 (2): 265–274. http://jpet.aspetjournals.org/cgi/content/abstract/152/2/265. Retrieved 2009-06-20.  
  2. ^ http://jpet.aspetjournals.org/cgi/content/abstract/152/2/265
  • Schaper WK, Xhonneux R, Jageneau AH., Stimulation of the coronary collateral circulation by lidoflazine (R 7904), Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1965 Nov 4;252(1):1-8.

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