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Litoxetine: Wikis

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Systematic (IUPAC) name
CAS number 86811-09-8
ATC code none
PubChem 65650
Chemical data
Formula C16H19NO 
Mol. mass 241.327 g/mol
SMILES eMolecules & PubChem
Therapeutic considerations
Pregnancy cat.  ?
Legal status

Litoxetine (SL-810,385) is a psychoactive drug and research chemical that was under development as an antidepressant in the early 1990s.[1] It functions as a selective serotonin reuptake inhibitor (SSRI) and potent 5-HT3 receptor antagonist. It has prominent antiemetic properties, and unlike other SSRIs, was shown to have a negligible incidence of nausea and emesis.[2] Development of litoxetine was apparently halted in the late 1990s.


  1. ^ Fairweather DB, Patat A, Rosenzweig P, Curson VH, Dunmore C, Dubruc C, Hindmarch I (August 1995). "The psychomotor and cognitive effects of litoxetine in young and middle aged volunteers". British Journal of Clinical Pharmacology 40 (2): 119–25. PMID 8562293. 
  2. ^ Angel I, Schoemaker H, Prouteau M, Garreau M, Langer SZ (March 1993). "Litoxetine: a selective 5-HT uptake inhibitor with concomitant 5-HT3 receptor antagonist and antiemetic properties". European Journal of Pharmacology 232 (2-3): 139–45. PMID 8385615. 

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